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| 1 | HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt显示文摘AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its genotype.METHODS:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by ELISA.Three hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA sequencing.RESULTS:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level HBsAb.Poor responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied groups.Markers of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by AxSYM.Other markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E infection.CONCLUSION:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and adults.The vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination. | Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya M Fahmy | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Overexpression of human cardiac troponin I and troponin-C in Escherichia coli and their purification 显示文摘 | Eman A Stephen D Ian P | 1994 | Eur J Biochem1994，225，： | 2 |
| 3 | Hemivertebra excision in children via simultaneous anterior and posterior exposures 显示文摘 | Hedequist D J Hall JE Emans JB | 2005 | J Pediatr Orthop2005，25，： | 1 |
| 4 | Three rod technique fa- cilitates hemivertebra wedge excision in young children through a posterior only approach 显示文摘 | Hedequist D Emans J Praetor M | 2009 | Spine2009，34，： | 1 |
| 5 | Congenital scoliosis:a review and update显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，1： | 1 |
| 6 | The correlation of preoperative three-dimensional computed tomography reconstructions with operative findings in congenital scoliosis显示文摘 | Hedequist D J Emans JB | 2003 | Spine2003，28，22： | 1 |
| 7 | Congenital scoliosis显示文摘 | Hedequist D Emans J | 2004 | J Am Acad Orthop Surg2004，12，4： | 1 |
| 8 | Congenital scoliosis:a review and update显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，： | 1 |
| 9 | Hemivertebra excision in children via simultaneous anterior and posterior exposures 显示文摘 | Hedequist D J Hall J E Emans J B | 2005 | J Pediatr Orthop2005，25，1： | 1 |
| 10 | Stochastic relaxation, Gibbs distribution, and the Bayesian restoration of images 显示文摘 | C eman S C eman D | 1984 | IEEE Trans Pattern Anal Machine Intell1984，6，6： | 1 |
| 11 | Congenital scoliosis: a review and update 显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，： | 1 |
| 12 | Congenital scoliesis: a review and update显示文摘 | Hedquist D Emans J | 2007 | Pediatr Orthop2007，27，1： | 1 |
| 13 | Congenital scoliosis:a review and update 显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orthop2007，27，： | 1 |
| 14 | Congenital scoliosis显示文摘 | Hedequist D Emans J | 2004 | Am Acad Orthop Surg2004，12，4： | 1 |
| 15 | Threc rod techniquc facilitaics hemivertebra wedge excision in young childen through a posterior only approach显示文摘 | Hcdcquist D Emans J Proctor M | 2009 | Spine2009，19，6： | 1 |
| 16 | Hemivertebra excision in children via simultaneous anterior and posterior exposures 显示文摘 | Hedequist D J Hall JE Emans JB | 2005 | J Pediatr Or- thop2005，25，： | 1 |
| 17 | Activation of NF-kB/p65 facilitates early chondrogenic differentiation dur- ing endochondral ossification显示文摘 | CARON M J EMANS P J SURTEL D A | 2012 | PLoS One2012，7，33： | 1 |
| 18 | Congenital scoliosis : a review and update显示文摘 | Hedequist D Emans J | 2007 | J Pediatr Orhop2007，27，： | 1 |
| 19 | Congenital scoliosis:a review and update显示文摘 | Hedequist D Emans J | 2009 | J Pediatr Orhop2009，27，： | 1 |
| 20 | Single stage re- duction and stabilization of basilar invagination after failed prior fusion surgery in children with Down's syndrome 显示文摘 | Hedequist D Bekelis K Emans J | 2010 | Spine2010，35，4： | 1 |
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