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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | A new approach for visual identification of orange varieties using neural networks and metaheuristic algorithms显示文摘Accurate classification of fruit varieties in processing factories and during post-harvesting applications is a challenge that has been widely studied.This paper presents a novel approach to automatic fruit identification applied to three common varieties of oranges(Citrus sinensis L.),namely Bam,Payvandi and Thomson.A total of 300 color images were used for the experiments,100 samples for each orange variety,which are publicly available.After segmentation,263 parameters,including texture,color and shape features,were extracted from each sample using image processing.Among them,the 6 most effective features were automatically selected by using a hybrid approach consisting of an artificial neural network and particle swarm optimization algorithm(ANN-PSO).Then,three different classifiers were applied and compared:hybrid artificial neural network–artificial bee colony(ANN-ABC);hybrid artificial neural network–harmony search(ANN-HS);and k-nearest neighbors(kNN).The experimental results show that the hybrid approaches outperform the results of kNN.The average correct classification rate of ANN-HS was 94.28%,while ANN-ABS achieved 96.70%accuracy with the available data,contrasting with the 70.9%baseline accuracy of kNN.Thus,this new proposed methodology provides a fast and accurate way to classify multiple fruits varieties,which can be easily implemented in processing factories.The main contribution of this work is that the method can be directly adapted to other use cases,since the selection of the optimal features and the configuration of the neural network are performed automatically using metaheuristic algorithms. | Sajad Sabzi Yousef Abbaspour-Gilandeh Ginés García-Mateos | 2018 | Information Processing in Agriculture2018，5，1： | 8 |
| 3 | Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis显示文摘 | Andrés Cárdenas Pere Ginès Paul Marotta Frank Czerwiec John Oyuang Mónica Guevara Nezam H Afdhal | 2011 | Journal of Hepatology2011，，3： | 6 |
| 4 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 5 | Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: A prospective study显示文摘 | Javier Fernández Juan Acevedo Miriam Castro Orlando Garcia Carlos Rodríguez de Lope Daria Roca Marco Pavesi Elsa Sola Leticia Moreira Anibal Silva Tiago Seva‐Pereira Francesco Corradi Jose Mensa Pere Ginès Vicente Arroyo | 2012 | Hepatology2012，，： | 4 |
| 6 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 7 | Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis显示文摘 | Marlene Dominguez Rosa Miquel Jordi Colmenero Montserrat Moreno Joan–Carles García–Pagán Jaime Bosch Vicente Arroyo Pere Ginès Juan Caballería Ramón Bataller | 2009 | Gastroenterology2009，，5： | 3 |
| 8 | Renal Failure in Patients With Cirrhosis and Sepsis Unrelated to Spontaneous Bacterial Peritonitis: Value of MELD Score显示文摘 | Carlos Terra Mónica Guevara Aldo Torre Rosa Gilabert Javier Fernández Marta Martín-Llahí Maria E. Baccaro Miquel Navasa Conxita Bru Vicente Arroyo Juan Rodés Pere Ginès | 2005 | Gastroenterology2005，，6： | 2 |
| 9 | Renal and circulatory dysfunction in cirrhosis: Current management and future perspectives显示文摘 | Elsa Solà Pere Ginès | 2010 | Journal of Hepatology2010，，6： | 2 |
| 10 | Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study显示文摘 | Mónica Guevara Carlos Terra André Nazar Elsa Solà Javier Fernández Marco Pavesi Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，4： | 2 |
| 11 | Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Polkowski A. Larghi P. Vilmann M. Giovannini J.-L. Frossard D. Heresbach B. Pujol G. Fernández-Esparrach E. Vazquez-Sequeiros A. Ginès | 2011 | Endoscopy2011，，10： | 2 |
| 12 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 13 | Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis显示文摘 | Pere Ginès Juan Uriz Blas Calahorra Guadalupe Garcia–Tsao Patrick S. Kamath Luis Ruiz Del Arbol Ramón Planas Jaime Bosch Vicente Arroyo Juan Rodés | 2002 | Gastroenterology2002，，6： | 2 |
| 14 | Pathogenesis and Treatment of Hepatorenal Syndrome显示文摘 | Vicente Arroyo Javier Fernandez Pere Ginès | 2008 | Semin Liver Dis2008，，01： | 2 |
| 15 | The fate of silicon during glass corrosion under alkaline conditions: A mechanistic and kinetic study with the International Simple Glass 显示文摘 | Gin S Jollivet P Fournier M | 2015 | Geochimica et Cosmochimica Acta2015，151，： | 1 |
| 16 | Spectral irradiance profiles of suspended marine clay for the estimation of suspended sediment concentration in tropical waters显示文摘 | GIN K Y-H KOH S T LIN I-I | 2003 | International Journal of Remote Sensing2003，24，16： | 1 |
| 17 | Definition and diagnostic criteria of retractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | Arroyo V Ginès P Gerbes AL | | 0，，01： | 1 |
| 18 | SON68 nuclear glass dissolution kinetics: Current state ofknowledge and basis of the new GRAAL model 显示文摘 | Frugier P Gin S Minet Y | 2008 | Journal of Nuclear Materials2008，380，： | 1 |
| 19 | Enantioselective Iotal synthe sis of ecteinascidin 743显示文摘 | Corey E J Gin D Y Kania R S | 1996 | J Am Chem Soc1996，118，38： | 1 |
| 20 | Synergy between intracoronary stenting ang abciximab in improving angiographic and clinical out-comes of primary angioplasty inacute myocardial infarction显示文摘 | Gin S Mitchel JF Hirst JA | 2000 | Am J Cardial2000，86，： | 1 |
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