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| 1 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
| 2 | Molecular confocal laser endomicroscopy:A novel technique for in vivo cellular characterization of gastrointestinal lesions显示文摘While flexible endoscopy is essential for macroscopic evaluation,confocal laser endomicroscopy(CLE)has recently emerged as an endoscopic method enabling visualization at a cellular level.Two systems are currently available,one based on miniprobes that can be inserted via a conventional endoscope or via a needle guided by endoscopic ultrasound.The second system has a confocal microscope integrated into the distal part of an endoscope.By adding molecular probes like fluorescein conjugated antibodies or fluorescent peptides to this procedure(either topically or systemically administered during on-going endoscopy),a novel world of molecular evaluation opens up.The method of molecular CLE could potentially be used for estimating the expression of important receptors in carcinomas,subsequently resulting in immediate individualization of treatment regimens,but also for improving the diagnostic accuracy of endoscopic procedures by identifying otherwise invisible mucosal lesions.Furthermore,studies have shown that fluorescein labelled drugs can be used to estimate the affinity of the drug to a target organ,which probably can be correlated to the efficacy of the drug.However,several of the studies in this research field have been conducted in animal facilities or in vitro,while only a limited number of trials have actually been carried out in vivo.Therefore,safety issues still needs further evaluations.This review will present an overview of the implications and pitfalls,as well as future challenges of molecular CLE in gastrointestinal diseases. | John Gasdal Karstensen Pia Helene Klausen Adrian Saftoiu Peter Vilmann | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 3 | Contrast-enhanced endoscopic ultrasonography显示文摘Contrast agents are increasingly being used to characterize the vasculature in an organ of interest,to better delineate benign from malignant pathology and to aid in staging and directing therapeutic procedures.We review the mechanisms of action of first,second and third generation contrast agents and their use in various endoscopic procedures in the gastrointestinal tract.Various applications of contrast-enhanced endoscopic ultrasonography include differentiating benign from malignant mediastinal lymphadenopathy,assessment of depth of invasion of esophageal,gastric and gall bladder cancers and visualization of the portal venous system and esophageal varices.In addition,contrast agents can be used to differentiate pancreatic lesions.The use of color Doppler further increases the ability to diagnose and differentiate various pancreatic malignancies.The sensitivity of power Doppler sonography to depict tumor neovascularization can be increased by contrast agents.Contrast-enhanced harmonic imaging is a useful aid in identifying the tumor vasculature and studying pancreatic microperfusion.In the future,these techniques could potentially be used to quantify tumor perfusion,to assess and monitor the efficacy of antiangiogenic agents,to assist targeted drug delivery and allow molecular imaging. | Nischita K Reddy Ana Maria Ioncicǎ Adrian Sǎftoiu Peter Vilmann Manoop S Bhutani | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | Endosonography guided management of pancreatic fluid collections显示文摘The revised Atlanta classification of acute pancreatitis was adopted by international consensus, and is based on actual local and systemic determinants of disease severity. The local determinant is pancreatic necrosis(sterile or infected), and the systemic determinant is organ failure. Local complications of pancreatitis can include acute peri-pancreatic fluid collection, acute necrotic collection, pseudocyst formation, and walledoff necrosis. Interventional endoscopic ultrasound(EUS) has been increasing utilized in managing these local complications. After performing a Pub Med search, the authors manually applied pre-defined inclusion criteria or a filter to identify publications relevant to EUS and pancreatic collections(PFCs). The authors then reviewed the utility, efficacy, and risks associated with using therapeutic EUS and involved EUS devices in treating PFCs. Due to the development and regulatory approval of improved and novel endoscopic devices specifically designed for transmural drainage of fluid and necrotic debris(access and patency devices), the authors predict continuing evolution in the management of PFCs. We believe that EUS will become an indispensable part of procedures used to diagnose PFCs and perform image-guided interventions. After draining a PFC, the amount of tissue necrosis is the most important predictor of a successful outcome. Hence, it seems logical to classify these collections based on their percentage of necrotic component or debris present when viewed by imaging methods or EUS. Finally, the authors propose an algorithm for managing fluid collections based on their size, location, associated symptoms, internal echogenic patterns, and content. | Andreas S Vilmann John Menachery Shou-Jiang Tang Indu Srinivasan Peter Vilmann | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 5 | Complementary roles of interventional radiology and therapeutic endoscopy in gastroenterology显示文摘Acute upper and lower gastrointestinal bleeding, enteral feeding, cecostomy tubes and luminal strictures are some of the common reasons for gastroenterology service. While surgery was initially considered the main treatment modality, the advent of both therapeutic endoscopy and interventional radiology have resulted in the paradigm shift in the management of these conditions. In this paper, we discuss the patient's work up, indications, and complementary roles of endoscopic and angiographic management in the settings of gastrointestinal bleeding, enteral feeding, cecostomy tube placement and luminal strictures. These conditions often require multidisciplinary approaches involving a team of interventional radiologists, gastroenterologists and surgeons. Further, the authors also aim to describe how the fields of interventional radiology and gastrointestinal endoscopy are overlapping and complementary in the management of these complex conditions. | David M Ray Indu Srinivasan Shou-jiang Tang Andreas S Vilmann Peter Vilmann Timothy C McCowan Akash M Patel | 2017 | World Journal of Radiology2017，9，3： | 2 |
| 6 | Hepatic applications of endoscopic ultrasound:Current status and future directions显示文摘The diagnosis and staging of various gastrointestinal malignancies have been made possible with the use of endoscopic ultrasound, which is a relatively safe procedure. The field of endoscopic ultrasound is fast expanding due to advancements in therapeutic endoscopic ultrasound. Though various studies have established its role in gastrointestinal malignancies and pancreatic conditions, its potential in the field of hepatic lesions still remains vastly untapped. In this paper the authors attempt to review important and landmark trials, case series and case studies involving hepatic applications of endoscopic ultrasound, thus not only providing an overview of utilization of endoscopic ultrasound in various liver conditions but also speculating its future role. | Indu Srinivasan Shou-Jiang Tang Andreas S Vilmann John Menachery Peter Vilmann | 2015 | World Journal of Gastroenterology2015，21，44： | 2 |
| 7 | Neural Network Analysis of Dynamic Sequences of EUS Elastography Used for the Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Adrian Saftoiu Peter Vilmann Florin Gorunescu Dan Ionut Gheonea Marina Gorunescu Tudorel Ciurea Gabriel Lucian Popescu Alexandru Iordache Sevastita Iordache | 2008 | Gastrointestinal Endoscopy2008，，5： | 2 |
| 8 | Contrast-enhanced harmonic endoscopic ultrasound显示文摘 | A. S?ftoiu C. Dietrich P. Vilmann | 2012 | Endoscopy2012，，06： | 2 |
| 9 | Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Polkowski A. Larghi P. Vilmann M. Giovannini J.-L. Frossard D. Heresbach B. Pujol G. Fernández-Esparrach E. Vazquez-Sequeiros A. Ginès | 2011 | Endoscopy2011，，10： | 2 |
| 10 | Accuracy of endoscopic ultrasound elastography used for differential diagnosis of focal pancreatic masses: a multicenter study显示文摘 | A. S?ftoiu P. Vilmann F. Gorunescu J. Janssen M. Hocke M. Larsen J. Iglesias-Garcia P. Arcidiacono U. Will M. Giovannini C. Dietrich R. Havre C. Gheorghe C. McKay D. Gheonea T. Ciurea | 2011 | Endoscopy2011，，07： | 2 |
| 11 | Real-time endobron- chial ultrasound-guided transbronchial needle aspiration for sam-piing mediastinal lymphnodes显示文摘 | Herth FJ Eberhardt R Vilmann P | 2006 | Thorax2006，61，9： | 1 |
| 12 | Consensus report of the 2nd International Conference on Double Balloon Endoscopy显示文摘 | J. Pohl J. Blancas D. Cave K. Choi M. Delvaux C. Ell G. Gay M. Jacobs N. Marcon T. Matsui A. May C. Mulder M. Pennazio E. Perez-Cuadrado K. Sugano P. Vilmann H. Yamamoto T. Yano J. Zhong | 2008 | Endoscopy2008，，02： | 1 |
| 13 | Endoscopic ultrasound guided biopsy of mediastinal lesions has a major impact on patient management显示文摘 | Larsen SS Kransnik M Vilmann P | 2002 | Thorax2002，57，： | 1 |
| 14 | Real - time endo- bronchial ultrasound guided transbronchial needle aspira- tion for sampling mediastinal lymph nodes 显示文摘 | Herth FJ Eberhardt R Vilmann P | 2006 | Thorax2006，61，9： | 1 |
| 15 | Randomized controlled trial of endoscopic ultrasound-guided fine-needle sampling with or without suction for better cytological diagnosis显示文摘 | Rajesh Puri Peter Vilmann Adrian S?ftoiu Birgit Guldhammer Skov Dorte Linnemann Hazem Hassan Elymir Soraya Galvis Garcia Florin Gorunescu | 2009 | Scandinavian Journal of Gastroenterology2009，，4： | 1 |
| 16 | EBUS - TBNA for the di- agnosis and staging of lung cancer 显示文摘 | Herth FJ Krasnik M Vilmann P | 2006 | Endoscopy2006，38，： | 1 |
| 17 | Endoscopic ultrasonography and real-time guided fine-needle aspiration biopsy of solid lesions of the mediastinum suspected of malignancy显示文摘 | Pederson BH Vilmann P Folke K | 1996 | Chest1996，110，2： | 1 |
| 18 | Real-time endobronchial ultrasound guided transbronchial needleaspiration for sampling me- diastinal lymph nodes 显示文摘 | Herth FJ Eberhardt R Vilmann P | 2006 | Thorax2006，61，9： | 1 |
| 19 | Endoscopic sphincterotomy for common bile duct stones during laparoscopic cholecystectomy is safe and effective显示文摘 | Jakobsen HL Vilmann P Rosenberg J | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，6： | 1 |
| 20 | Development of Obesity and Polycystic Ovary Syndrome in Adolescents 显示文摘 | Vilmann LS Thisted E Baker JL | 2012 | Horm Res Paediatr2012，78，56： | 1 |
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