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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Molecular cloning of a novel vascular endothelial growth factor, VEGF-D 显示文摘 | YamadaY Nezu J imane M | 1997 | Genomics1997，42，： | 1 |
| 4 | Effect of crosslinker and nanoclay on starch and jute fabric based green nanocomposites 显示文摘 | IMAN M MAJI T K | 2012 | Carbohydr Polym2012，89，： | 1 |
| 5 | Therapeutic face of RNAi: in vivo challenges显示文摘 | BORNA H IMANI S IMAN M | 2015 | Expert Opin Biol Ther2015，15，2： | 1 |
| 6 | Effect of annealing twins on Hall-Perch relation in polycrystalline materials显示文摘 | PANDE C S RATH B B IMAN M A | 2004 | Mater Sci Eng A2004，367，： | 1 |
| 7 | Lithologic characteristics and diagenesis of the Devonian Jauf sandstone at Ghawar Field, Eastern Saudi Arabia显示文摘 | AI-Ramadan K A Hussain M Iman B | 2004 | Marine and Petroleum Geology2004，21，10： | 1 |
| 8 | The effects of canal preparation by different NiTi rotary instruments and reciprocating WaveOne file on the in- cidence of dentinal defects 显示文摘 | Iman M A1-Zaka | 2012 | MDJ2012，9，2： | 1 |
| 9 | Serum zinc level as a predictor of subclinical hepatic encephalopathy in patients with liver cirrhosis 显示文摘 | Iman R Wahid D Salwa M | 2008 | Arab J Gastroenterol2008，9，4： | 1 |
| 10 | En- gaging older adults in their transitional care: what more needs to be done显示文摘 | NAYLOR M D HIRSC/-IMAN K B O'CONNOR M | 2013 | J Comp Eft Res2013，2，5： | 1 |
| 11 | lnvitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon显示文摘 | Atyabi F Majzoob S Iman M | 2005 | Carbohydrate Polymers2005，61，： | 1 |
| 12 | Efficacy of charge sharing in reshaping the surface electric field in high-vohage lateral RESURF devices显示文摘 | IMAN M QUDDUS M ADAMS J | 2004 | IEEE Trans on Electron Devices2004，51，1： | 1 |
| 13 | Reinforcing epoxy polymer composites through covalent integration of functionalized nanotubes 显示文摘 | Zhu J Peng H Q Rodriguez-Macias F Margrave J L Khabashesku V N Iman A M Lozano K Barrera E V | 2004 | Adv Funct Mater2004，14，7： | 1 |
| 14 | Three-dimensional shape optimization显示文摘 | Iman M H | 1982 | Int J Num Meth in Eng1982，18，： | 1 |
| 15 | Applying Shared-parking Turn- time (SPATT) Model and Geographic Information System in the Supply and Demand Analysis of Park- ing Space显示文摘 | IMAN M HAMID B | 2006 | Malaysian Journal of Real Estate2006，1，2： | 1 |
| 16 | Sensitivity analysis for computer model projections of hurricane losses显示文摘 | Iman R L Johnson M E Watson Jr C C | 2005 | Risk Analysis2005，25，5： | 1 |
| 17 | Uncertainty analysis for computer model projections of hurricane losses显示文摘 | Iman R L Johnson M E Watson Jr C C | 2005 | Risk Analysis2005，25，5： | 1 |
| 18 | Statistical aspects of forecasting and planning for hurricanes显示文摘 | Iman R L Johnson M E Watson Jr C C | 2006 | American Statistician2006，60，2： | 1 |
| 19 | Social-Network-Sourced Big Data Analytics 显示文摘 | TAN Wei BRIAN M BLAKE IMAN SALEH | 2013 | Internet Computing IEEE2013，17，5： | 1 |
| 20 | Targeted core-crosslinkedpolymeric micelles with controlled release of covalently entrappeddoxorubicin显示文摘 | Talelli M Iman M Rijcken C J | 2010 | J Control Release2010，148，1： | 1 |
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