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| 1 | 14-3-3蛋白与阿尔茨海默病tau蛋白异常磷酸化的关系显示文摘目的研究阿尔茨海默病(Alzheimerdisease,AD)患者海马组织1433蛋白家族与神经原纤维缠结(NFT)形成及tau蛋白异常磷酸化之间的关系。方法以4例临床及病理确诊的AD患者及4名对照者海马组织为材料,用免疫组织化学、免疫印迹及免疫共沉淀技术来研究1433蛋白在AD患者海马的表达情况及其与异常磷酸化tau蛋白之间的关系。结果1433蛋白ζ及γ亚型能使AD患者海马的NFT显色,β亚型主要使海马的颗粒神经元着色,同时也使少许NFT染色。免疫印迹显示β和ζ亚型在AD中明显上调,其像素值(分别为4570±92和5630±40)比对照组(分别为1849±65和956±140)高2~3倍(P<0.01,t检验)。免疫共沉淀分析发现单抗双螺旋细丝(PHF1)从AD患者脑中沉淀的1433蛋白像素值(3859±78)显著多于对照组(1540±138,AD组像素值比对照组高1倍,P<0.05,t检验),这3种亚型均与异常磷酸化tau蛋白在AD患者脑部形成复合物。σ亚型在AD患者和对照组脑中均无表达。上述发现在4名对照者脑组织中并未观察到。结论β、ζ及γ亚型1433蛋白参与NFT形成,它们均可能参与tau蛋白的磷酸化调节,具体机制有待阐明。 | 卜碧涛 张旻 王伟 Inez Vincent | 2005 | 中华神经科杂志2005，38，10： | 13 |
| 2 | Plant Cover and Soil Biochemical Properties in a Mine Tailing Pond Five Years After Application of Marble Wastes and Organic Amendments显示文摘Tailing ponds pose environmental hazards,such as toxic metals which can contaminate the surroundings through wind and water erosions and leaching.Various chemical and biochemical properties,together with extractable and soluble metals were measured five years after reclamation of a polluted soil affected by former mining activities.This abandoned mine site contains large amounts of Fe-oxyhydroxides,sulphates,and heavy metals.As a consequence,soils remain bare and the soil organic matter content is low(< 3 g kg 1).Marble waste,pig manure and sewage sludge were applied in 2004.Plant cover and richness,and soil chemical,biochemical and biological parameters were analysed five years later.Results showed that all soil biochemical properties as well as vegetation cover and richness were higher in treated soils than in the untreated contaminated plots(control),although organic matter,pH values and extractable metals concentrations were similar among treatments.Soluble cadmium and zinc were lower in the amended plots than in control.As a general pattern,soil amended with pig manure showed higher values of most biochemical properties compared to sewage sludge application,while the doses did not have a great effect,being only significant for β-glucosidase,phosphodiesterase and arylsulfatase.Significant correlations were found between vegetation cover,richness and soil biochemical properties,suggesting a high interdependence between plant colonization and reactivation of biogeochemical cycles during five years.This study confirms the high effectiveness of an initial application of the amendments tested to initialize the recovery of ecosystems in bare mine soils under Mediterranean semiarid conditions.This research also shows the high sensitivity of certain biochemical properties in order to evaluate soil quality and reactivation of nutrients cycles in reclaimed mine soils. | R.ZORNOZA A.FAZ D.M.CARMONA S.KABAS S.MARTíNEZ-MARTíINEZ J.A.ACOSTA | 2012 | Pedosphere2012，22，1： | 6 |
| 3 | CPB的冠脉手术病人主要麻醉方法的选择影响术后ICU住院时间显示文摘 | Stefan G.De Hert Philippe J.Van der Linden Stefanie Cromheecke Roel Meeus Pieter W.ten Broecke Ivo G.De Blier Bernard A.tockman Inez E.Rodrigus 刘功俭(译) 曾因明(审) | 2004 | 国外医学(麻醉学与复苏分册)2004，25，4： | 4 |
| 4 | Enhanced sonochemical decomposition of 1,4 -dioxane by ferrous iron显示文摘 | Michael A Beckett Inez Hua | 2003 | Water Research2003，，37： | 1 |
| 5 | Kinetics and mechanism of the sonolytic degradation of CCl4:Intermediates and byproducts显示文摘 | INEZ H NICK S | | 0，，： | 1 |
| 6 | Microstructural characterization of monolithic ceramic matrix composites from polysiloxane and SiC powder显示文摘 | MARCO ANTONIO SCHIAVON EDUARDO RADOVANOVIC INEZ VALERIA PAGOTTO YOSHIDA | 2002 | Powder Technology2002，123，： | 1 |
| 7 | Sonnolytic Hydrolysis of Pnitrophenyl Acetate:The Role of Supercritical Water显示文摘 | Ualf H Hochemer Micchale R Hoffmanu | 1995 | Phys Chem1995，99，7： | 1 |
| 8 | Clinical sci- ence : Incidence of early-onset glaucoma after infant cataract extrac- tion with and without intraocular lens implantation 显示文摘 | Inez BYW Sukthankar VD Cortina-Borja M | 2009 | Br J Oph- thalmol2009，93，9： | 1 |
| 9 | Antioxidant activity of Cod ( Gadus morhua ) protein hydrolysates: Part 1 – In vitro assays and evaluation in 5% fish oil-in-water emulsion显示文摘 | K.H. Sabeena Farvin Lisa Lystb?k Andersen Henrik Hauch Nielsen Charlotte Jacobsen Greta Jakobsen Inez Johansson Flemming Jessen | 2013 | Food Chemistry2013，，： | 1 |
| 10 | Application of ultrasonic irradiation for the degradation of chemical contaminants in water显示文摘 | Hoffmann Michael R Hua Inez H?chemer Ralf | 1996 | Ultrasonics Sonochemistry1996，3，3： | 1 |
| 11 | Application of ultrasonic irradiation for the degradation of chemical contaminants in water显示文摘 | Hoffmann Michael R Hua Inez Hochemer Ralf | 1996 | Ultrasonics Sonochemistry1996，3，3： | 1 |
| 12 | Modification of the response of saline stressed tomato plants by the correction of cation disorders显示文摘 | Carvajal M Cerd A inez V M | 2000 | Plant Growth Regulation2000，，30： | 1 |
| 13 | Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation 显示文摘 | Roel W Herman S Inez R | 2002 | Exp Hematol2002，30，7： | 1 |
| 14 | Using a model to evaluate nursing education and professional practise显示文摘 | Inez Kapborg | 2002 | Nursing and Health Sciences2002，，4： | 1 |
| 15 | Performance monitoring of industrial controllers based on the predictability of controller behavior 显示文摘 | Ghraizid R A Mart'inez E Prada C'esar de | 2007 | Computers & Chemical Engineering2007，31，56： | 1 |
| 16 | Gastroesophageal reflux disease: Its importance in ear, nose, and throat practice显示文摘 | Silvia R.M.C.L. Megale Adriana B.A. Scanavini Eduardo C. Andrade Maria Inez Machado Fernandes Wilma T. Anselmo-Lima | 2005 | International Journal of Pediatric Otorhinolaryngology2005，，： | 1 |
| 17 | Modified Seldinger Technique with Ultra- sound for PICC Placement in the Pediatric Patient: A Pre- cise Advantage显示文摘 | Darcy D Inez N | 2009 | JAVA2009，14，2： | 1 |
| 18 | The efficacy of upper armplacement of pe- ripherally inserted central catheters U-sing bedside ultra-sound and microintroducer technique显示文摘 | Inez N James PH | 2008 | Journal of lnfusionNursing2008，，： | 1 |
| 19 | Contribution to the atmospheric mineral aerosol load from land surface modification显示文摘 | Inez Fung | 1995 | -%Jurnal of Geophysical Research-%1995，100，18： | 1 |
| 20 | A uninucleate wheat-infecting strain of the stem rust fungus isolated from axenic cultures 显示文摘 | Maclean D J Inez C T Scott K J | 1971 | Journal of General Microbiology1971，65，： | 1 |
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