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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 3 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 4 | 荷兰不同来源耐多药结核病例中二线耐药情况显示文摘背景:荷兰。目的:调查不同地理来源的耐多药结核病人耐二线药情况及其相关因素。方法:对荷兰1993年1月至2007年10月间耐多药结核病人分离菌株的实验室数据进行回顾性研究。结果:发现的153例耐多药结核病人中,18例(12%)为荷兰本国人。对其中的131例进行二线药物敏感性实验,有28例(21%)为耐二线药,且大部分为单一耐药(24/28(86%));9例耐丙硫异烟胺(PTH),6例耐对氨基水杨酸,4例耐阿米卡星(ASK),4例耐环丙沙星,1例耐环丝氨酸)。有4例耐多药结核病人耐多种二线药;2例为广泛耐药的牛型结核分枝杆菌。在所有耐多药结核病人中,来自欧洲和中亚者二线耐药较普遍,且涉及的药物也较广泛。来自非洲和美洲者主要耐PTH,而来自东南亚者主要耐AMK。结论:在荷兰,耐多药结核病人中二线耐药情况并不普遍。大部分二线耐药发生在移民当中,来源于不同的地域,病人耐药情况也不同。 | J. van Ingen M. J. Boeree A. Wright T. van der Laan P. N. R. Dekhuijzen D. vanSoolingen 刘青(译) 何广学(审校) | 2009 | 国际结核病与肺部疾病杂志2009，4，2： | 3 |
| 5 | Chemical species distribution and transformation in polyaluminum chemical solutions显示文摘The hydrolysis polymerization precipitation process of Al(III) was studied with pH titration method, and the prepared polyaluminum solutions were characterized by various experimental methods: acid depolymerization, timed complex-colorimetric procedure, ultrafiltration, X-ray diffraction and infrared absorption spectrum. The results showed that the chemical species transformation and distribution of Al(III) in the hydrolysis-polymerization process depended on B=(OH/Al) ratio, pH and other factors. By their structures, the chemical species can be divided into three categories of monomeric (Ala), polymeric (Alb), sol or gel precipitates (Alc) and the polymeric species may be further divided into three groups such as linear low polymer (Alb1), linear high polymer (Alb2) and high polymer with cyclic structure (Alb3). The nominal molecular weight of polymeric species obtained by ultrafiltration was about 1000-50000 and most of them failed into a range around 10000. A scheme for the chemical speciation | Laan Zhaokun and Tang HongxiaoResearch Center for Environmental Sciences,Academia Sinica,Beijing 100083,China. | 1990 | Journal of Environmental Sciences1990，2，2： | 2 |
| 6 | A chromatic premirror system for a double-crystal monochromator显示文摘 | VAN DER LAAN G | 1990 | Nucl Instrum Methods A1990，291，1： | 2 |
| 7 | Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: An association with C显示文摘 | Angela S. W. Tjon Jerome Sint Nicolaas Jaap Kwekkeboom Robert A. de Man Geert Kazemier Hugo W. Tilanus Bettina E. Hansen Luc J. W. van der Laan Thanyalak Tha‐In Herold J. Metselaar | 2010 | Liver Transpl2010，，7： | 2 |
| 8 | Leadtimes effects and policy improvement for stochastic inventory control with remanufacturing显示文摘 | Inderfurth K Laan E V D | 2001 | International Journal of Production Economics2001，71，13： | 1 |
| 9 | The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry 显示文摘 | Honeywell R Laan AC van Groeningen C J | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，847，2： | 1 |
| 10 | Soluble E - selectin,other markers of inflammation and disease severity in children with atopie dermatitis显示文摘 | Wolkerstorfer A Laan MP Savelkoul HF | 1998 | Br J Dermatol1998，138，3： | 1 |
| 11 | Simple Heuristics for Push and Pull Remanufacturing Policies 显示文摘 | Erwin A Vander Laan Ruud H Teunter | 2006 | European Journal of Operational Research2006，，175： | 1 |
| 12 | Surgical clipp- ing as the preferred treatment for aneurysms of the middle cerebral artery 显示文摘 | van Dijk JM Groen RJ Ter Laan M | 2011 | Acta Neurochir (Wien)2011，153，11： | 1 |
| 13 | Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo 显示文摘 | Hoshino H Laan M Sjostrand M | 2000 | J Allergy Clin Immunol2000，105，11： | 1 |
| 14 | The transfer of protein crystals front their original mother liquor to a solution with a completely different precipitant 显示文摘 | Schreuder H A Groendijk H van der Laan J M | 1988 | J Appl Crystallogr1988，21，： | 1 |
| 15 | Characterization of mRAD18Sc,a mouse homolog of the yeast postreplicaiton repair gene RAD18显示文摘 | Roald van der Laan Henk P Roest Jos W Hoogerbrugge | 2000 | Genomics2000，69，： | 1 |
| 16 | Neutrophils, interleukin-17A and lung disease 显示文摘 | Linden A Laan M Anderson GP | 2005 | Eur Respir J2005，25，1： | 1 |
| 17 | Clinical recommendations on the treatment of neuroendoerine carcinoma of the larynx: A meta-analysis of 436 reported cases显示文摘 | VAN DER LAAN T P PLAAT B E VAN DER LAAN B F | 2015 | Head Neck2015，37，： | 1 |
| 18 | Asymptotic optimality of likelihood-based Cross-Validation 显示文摘 | LAAN MARK VAN DER J SANDRINE D SUNDUZ K | 2004 | Statistical Applications in Genetics and Molecular Biolo- gy2004，3，： | 1 |
| 19 | Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo显示文摘 | Hoshino H Laan M Sjostrand M | 2000 | J Allergy Clin Immunol2000，105，11： | 1 |
| 20 | Inventory control in hybrid systems with remanufacturing显示文摘 | Erwin van der Laan Marc Salomon Rommert Dekker Luk Van Wassenhove | 1999 | Management Science1999，，5： | 1 |
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