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| 1 | Effect of acupuncture therapies combined with usual medical care on knee osteoarthritis显示文摘OBJECTIVE: To observe the effect of acupuncture or electroacupuncture(EA) combined with usual medical care for treating knee osteoarthritis(KOA).METHODS: A total of 90 patients with KOA were randomly allocated to 3 groups: usual care group(UC group, n = 30) was treated by pharmacological treatment of non-steroidal anti-inflammatory drugs(NSAIDs) and drugs for activating blood circulation(Ds-ABC), acupuncture(AP) combined with usual care group(UC group)(AP + UC group, n =30) and EA combined with UC group(EA + UC group, n = 30). The primary outcome measurements included pain visual analogue scale/score(VAS), Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC Index) and its subscales. Secondary outcome measurement was Assessment of Quality of Life instrument version of the 36-item Short Form Health Survey(AQoL-SF36).RESULTS: By the end of the 1 st week, AP + UC group and EA + UC group exhibited statistically significant improvements in primary outcome measures, except for WOMAC stiffness, compared with the UC group(P < 0.05). Moreover, the energy/fatigue domain of AQoL-SF36 in the AP + UC group showed better results than UC group(P < 0.05). By the end of the 2 nd week, all the primary outcome measures revealed that either the AP + UC or EA +UC group demonstrating remarkable advantages compared with the UC group(P < 0.05). The social functioning and general health domains of AQoLSF36 in the two acupuncture-intervention groups were improved significantly than UC group(P <0.05). We also found the energy/fatigue and emotional wellbeing domains of AQoL-SF36 in the EA +UC group demonstrated better results than UC group(P < 0.05).CONCLUSION: AP or EA combined with usual care is more effective than usual care alone for the treatment of KOA, the intervention of electric current in the process of acupuncture may improve more domains of AQoL-SF36 in KOA patients. | Zhang Lele Yuan Haixin Zhang Lei Li Jian Li Hongmei | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 5 |
| 2 | Online adaptive Q-learning method for fully cooperative linear quadratic dynamic games显示文摘A model-based offline policy iteration(PI) algorithm and a model-free online Q-learning algorithm are proposed for solving fully cooperative linear quadratic dynamic games. The PI-based adaptive Q-learning method can learn the feedback Nash equilibrium online using the state samples generated by behavior policies, without sending inquiries to the system model. Unlike the existing Q-learning methods, this novel Q-learning algorithm executes both policy evaluation and policy improvement in an adaptive manner.We prove the convergence of the offline PI algorithm by proving its equivalence to Newton’s method while solving the game algebraic Riccati equation(GARE). Furthermore, we prove that the proposed Q-learning method will converge to the Nash equilibrium under a small learning rate if the method satisfies certain persistence of excitation conditions, which can be easily met by suitable behavior policies. Our simulation results demonstrate the good performance of the proposed online adaptive Q-learning algorithm. | Xinxing LI Zhihong PENG Lei JIAO Lele XI Junqi CAI | 2019 | Science China(Information Sciences)2019，62，12： | 4 |
| 3 | A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity显示文摘Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−1.The studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical devices.Maximizing areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal technologies.Herein,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading electrode.By specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass loading.Additionally,the 3D porous graphene network structure in LHGF ensures excellent electron and ion transport.By systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research devices.Furthermore,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries. | Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang Xu Junfei Liang Huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan | 2022 | Nano-Micro Letters2022，14，3： | 4 |
| 4 | Retrieval of Snow Depth on Sea Ice in the Arctic Using the FengYun-3B Microwave Radiation Imager显示文摘Snow on sea ice is a sensitive indicator of climate change because it plays an important role regulating surface and near surface air temperatures. Given its high albedo and low thermal conductivity, snow cover is considered a key reason for amplified warming in polar regions. This study focuses on retrieving snow depth on sea ice from brightness temperatures recorded by the Microwave Radiation Imager(MWRI) on board the FengYun(FY)-3 B satellite. After cross calibration with the Advanced Microwave Scanning Radiometer-EOS(AMSR-E) Level 2 A data from January 1 to May 31, 2011, MWRI brightness temperatures were used to calculate sea ice concentrations based on the Arctic Radiation and Turbulence Interaction Study Sea Ice(ASI) algorithm. Snow depths were derived according to the proportional relationship between snow depth and surface scattering at 18.7 and 36.5 GHz. To eliminate the influence of uncertainties in snow grain sizes and sporadic weather effects, seven-day averaged snow depths were calculated. These results were compared with snow depths from two external data sets, the IceBridge ICDIS4 and AMSR-E Level 3 Sea Ice products. The bias and standard deviation of the differences between the MWRI snow depth and IceBridge data were respectively 1.6 and 3.2 cm for a total of 52 comparisons. Differences between MWRI snow depths and AMSR-E Level 3 products showed biases ranging between-1.01 and-0.58 cm, standard deviations from 3.63 to 4.23 cm, and correlation coefficients from 0.61 to 0.79 for the different months. | LI Lele CHEN Haihua GUAN Lei | 2019 | Journal of Ocean University of China2019，18，3： | 2 |
| 5 | The promises, challenges and pathways to room-temperature sodium-sulfur batteries显示文摘Room-temperature sodium-sulfur batteries(RT-Na-S batteries) are attractive for large-scale energy storage applications owing to their high storage capacity as well as the rich abundance and low cost of the materials.Unfortunately, their practical application is hampered by severe challenges, such as low conductivity of sulfur and its reduced products, volume expansion, polysulfide shuttling effect and Na dendrite formation,which can lead to rapid capacity fading. The review discusses the Na-S-energy-storage chemistry,highlighting its promise, key challenges and potential strategies for large-scale energy storage systems.Specifically, we review the electrochemical principles and the current technical challenges of RT-Na-S batteries, and discuss the strategies to address these obstacles. In particular, we give a comprehensive review of recent progresses in cathodes, anodes, electrolytes, separators and cell configurations, and provide a forward-looking perspective on strategies toward robust high-energy-density RT-Na-S batteries. | Lei Wang Tao Wang Lele Peng Yiliu Wang Meng Zhang Jian Zhou Maoxin Chen Jinhui Cao Huilong Fei Xidong Duan Jian Zhu Xiangfeng Duan | 2022 | National Science Review2022，9，3： | 2 |
| 6 | Tetracycline removal via adsorption and metal-free catalysis with 3D macroscopic N-doped porous carbon nanosheets:Non-radical mechanism and degradation pathway显示文摘Recently,metal-based carbon materials have been verified to be an effective persulfate activator,but secondary pollution caused by metal leaching is inevitable.Hence,a green metalfree 3D macroscopic N-doped porous carbon nanosheets(NPCN)was synthesized successfully.The obtained NPCN showed high adsorption capacity of tetracycline(TC)and excellent persulfate(PS)activation ability,especially when calcined at 700℃(NPCN-700).The maximum adsorption capacity of NPCN-700 was 121.51 mg/g by H-bonds interactions.Moreover,the adsorption process followed pseudo-second-order kinetics model and Langmuir adsorption isotherm.The large specific surface area(365.27 mg/g)and hierarchical porous structure of NPCN-700 reduced the mass transfer resistance and increased the adsorption capacity.About 96.39%of TC was removed after adding PS.The effective adsorption of the catalyst greatly shortened the time for the target organic molecules to migrate to the catalyst.Moreover,the NPCN-700 demonstrated high reusability with the TC removal rate of 80.23%after 4 cycles.Quenching experiment and electron paramagnetic resonance(EPR)test confirmed the non-radical mechanism dominated by ^(1)O_(2).More importantly,the C=O groups,defects and Graphitic N acted as active sites to generate ^(1)O_(2).Correspondingly,electrochemical measurement revealed the direct electron transfer pathway of TC degradation.Finally,multiple degradation intermediates were recognized by the LC-MS measurement and three possible degradation pathways were proposed.Overall,the prepared NPCN had excellent application prospects for removal of antibiotics due to its remarkable adsorption and catalytic degradation capabilities. | Yaqian Shen Ke Zhu Dongdong He Jin Huang Hongmei He Lele Lei Wenjin Chen | 2022 | Journal of Environmental Sciences2022，34，1： | 1 |
| 7 | Fe-N co-doped coral-like hollow carbon shell toward boosting peroxymonosulfate activation for efficient degradation of tetracycline: Singlet oxygen-dominated non-radical pathway显示文摘Fe-N co-doped coral-like hollow carbon shell (Fe-N-CS) was synthesized via a simply impregnation-pyrolysis method.The Fe-N-CS showed an excellent ability for activating peroxymonosulfate (PMS),which could degrade about 93.74%tetracycline (20 mg/L) in 12 min.The Fe-N-CS/PMS system exhibited a good anti-interference capacity of various pH,inorganic anions,HA and different water qualities.More importantly,the Fe nanoparticles were anchored uniformly in the carbon layer,effectively limiting the metal leaching.The quenching tests and electron spin resonance (ESR) manifested that non-radical singlet oxygen (1O_(2))was the main reactive oxygen species (ROS) for TC degradation.The mechanism study showed that Fe nanoparticles,defect and graphite N played a key role in activating PMS to produce ROS.Moreover,three probable degradation pathways were proposed by using LC-MS measurements.Generally,this work had a new insight for the synthesis of heterogeneous Fe-N-C catalysts in the advanced oxidation process based on PMS. | Wenjin Chen Jin Huang Yaqian Shen Ke Zhu Lele Lei Hongmei He Yushi Ai | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 8 | Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation显示文摘Cilia are cellular protrusions containing nine microtubule(MT)doublets and function to propel cell movement or extracellular liquid flow through beating or sense environmental stimuli through signal transductions.Cilia require the central pair(CP)apparatus,consisting of two CP MTs covered with projections of CP proteins,for planar strokes.How the CP MTs of such‘9+2’cilia are constructed,however,remains unknown.Here we identify Spef1,an evolutionarily conserved microtubule-bundling protein,as a core CP MT regulator in mammalian cilia.Spef1 was selectively expressed in mammalian cells with 9+2 cilia and specifically localized along the CP.Its depletion in multiciliated mouse ependymal cells by RNAi completely abolished the CP MTs and markedly attenuated ciliary localizations of CP proteins such as Hydin and Spag6,resulting in rotational beat of the ependymal cilia.Spef1,which binds to MTs through its N-terminal calponin.homologous domain,formed homodimers through its C-terminal coiled coil region to bundle and stabilize MTs.Disruption of either the MT-binding or the dimerization activity abolished the ability of exogenous Spef1 to restore the structure and functions of the CP apparatus.We propose that Spefl bundles and stabilizes central MTs to enable the assembly and functions of the CP apparatus. | Jianqun Zheng Hao Liu Lei Zhu Yawen Chen Huijie Zhao Wei Zhang Fan Li Lele Xie Xiumin Yan Xueliang Zhu | 2019 | Journal of Molecular Cell Biology2019，11，1： | 1 |
| 9 | Study on the freezing–thawing deformation of consolidated soils under high pressure显示文摘The freezing–thawing deformation behaviors of consolidated soils under high pressure have been investigated in a high-pressure-low-temperature(HPLT) K0 consolidation apparatus with a small strain sensor. The tests cover a variety of frozen soil temperatures ranging from-2 °C to-10 °C, and a series of applied pressures ranging from 1 MPa to 5 MPa. The test results show that, for the consolidated soils under high pressure, their freezing–thawing deformation was caused by the realignment and the deformation of soil particles, the phase change of water, and the water redistribution in the soil. As for the deformation produced by thermal expansion and contraction, it is about 0.04~0.05 mm, accounting for only about 7%~9% of the total deformation. Taking the freezing–thawing deformation produced by temperature disturbance as a creep deformation, the creep models of the developing soil deformation will be determined by the soil's final temperature, i.e., the desired temperature. For the soils under a desired temperature between-2 °C and-5 °C, the freezing–thawing deformation develops according to a non-attenuation creep model; but for the soils with a desired temperature lower than-5 °C, a full attenuation creep model is followed. The applied pressure and soil type also have a significant influence on the maximum freezing deformation. Generally, the greater the desired pressure applied, the less the maximum deformation is; and the loess freezing deformation is larger than that of sand. | DaYan Wang Wei Ma lele lei | 2017 | Research in Cold and Arid Regions2017，9，1： | 0 |
| 10 | Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release显示文摘Osteoarthritis(OA)has been regarded as a lubrication deficiency related joint disease.Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA.Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required.Herein,dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt)(PDA-PSPMA)conjugate coating on hollow silica(h-SiO_(2))nanosphere surfaces to engineer functional nanoparticles(h-SiO_(2)/PDA-PSPMA).The as-prepared h-SiO_(2)/PDA-PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA-PSPMA coating and'rolling'effect of h-SiO_(2)nanospheres.In vitro drug loading-release experiments demonstrate that PDA-PSPMA coating functionalized h-SiO_(2)nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug,diclofenac sodium(DS).Such h-SiO_(2)/PDA-PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication anddrugrelease. | Qiangbing WEI Tian FU Lele LEI Huan LIU Yixin ZHANG Shuanhong MA Feng ZHOU | 2023 | Friction2023，11，3： | 0 |
| 11 | Study on Multi-Scale Tensile Strength and Tensile Strain of Calcium Silicate Hydrate Layered Nanocomposites Under External Physical Field显示文摘Calcium silicate hydrate(C-S-H)is the mainly strength source of cement-based materials,but there is little basic research.In this paper,molecular dynamics method is applied to analyze the multi-scale tensile strength and tensile strain of C-S-H layered materials under the condition of external physical fields(temperature and strain rate).The results show that the tensile strength and strain of C-S-H model decrease with temperature raises.The temperature(from 1 K to 600 K)has obvious influence on the tensile strain and strength of C-S-H layered materials.In addition,at(0.00025 ps^(-1)-0.001 ps^(-1)),the tensile strain and strength of C-S-H layered materials are less sensitive to strain rate.The whole model is closer to a 3-dimensional deformation.However,at(0.001 ps^(-1)-0.005 ps^(-1)),the dynamic load effect begins to increase,and the work done by the load per unit time increased.The tensile strain and strength of C-S-H layered materials indicates intensified by the change of strain rate.The energies are randomly distributed in the system,not concentrated in a certain area. | Lei FAN Lele ZHANG | 2023 | Research and Application of Materials Science2023，5，1： | 0 |
| 12 | Peroxymonosulfate activation by Fe-N-S co-doped tremella-like carbocatalyst for degradation of bisphenol A: Synergistic effect of pyridine N, Fe-Nx, thiophene S显示文摘Bisphenol A(BPA)has received increasing attention due to its long-term industrial application and persistence in environmental pollution.Iron-based carbon catalyst activation of peroxymonosulfate(PMS)shows a good prospect for effective elimination of recalcitrant contaminants in water.Herein,considering the problem about the leaching of iron ions and the optimization of heteroatoms doping,the iron,nitrogen and sulfur co-doped tremellalike carbon catalyst(Fe-NS@C)was rationally designed using very little iron,S-C_(3)N_(4) and low-cost chitosan(CS)via the impregnation-calcination method.The as-prepared Fe-NS@C exhibited excellent performance for complete removal of BPA(20 mg/L)by activating PMS with the high kinetic constant(1.492 min^(−1))in 15 min.Besides,the Fe-NS@C/PMS system not only possessed wide pH adaptation and high resistance to environmental interference,but also maintained an excellent degradation efficiency on different pollutants.Impressively,increased S-C_(3)N_(4) doping amount modulated the contents of different N species in Fe-NS@C,and the catalytic activity of Fe-NS@C-1-x was visibly enhanced with increasing SC_(3)N_(4) contents,verifying pyridine N and Fe-Nx as main active sites in the system.Meanwhile,thiophene sulfur(C-S-C)as active sites played an auxiliary role.Furthermore,quenching experiment,EPR analysis and electrochemical test proved that surface-bound radicals(·OH and SO_(4)^(·−))and non-radical pathways worked in the BPA degradation(the former played a dominant role).Finally,possible BPA degradation route were proposed.This work provided a promising way to synthesize the novel Fe,N and S co-doping carbon catalyst for degrading organic pollutants with low metal leaching and high catalytic ability. | Wenjin Chen Lele Lei Ke Zhu Dongdong He Hongmei He Xiulan Li Yumeng Wang Jin Huang Yushi Ai | 2023 | Journal of Environmental Sciences2023，，7： | 0 |
| 13 | Smooth quadrotor trajectory generation for tracking a moving target in cluttered environments显示文摘In this paper,we present a trajectory generation method of a quadrotor,based on the optimal smoothing B-spline,for tracking a moving target with consideration of relative tracking pattern or limited field of view of the onboard sensor in cluttered environments.Compared to existing methods,safe flying zone,vehicle physical limits,and smoothness are fully considered to guarantee flight safety,kinodynamic feasibility,and tracking performance.To tackle the cluttered environments,a parallel particle swarm optimization algorithm is applied to find the feasible waypoints that the generated trajectory should be as close to as possible,with consideration of the target’s future state as well as obstacles to trade off the tracking performance and flight safety.Then,a sequential motion planning method,considering the above constraints,is applied and embedded into a cost function for solving the problem of robust tracking trajectory generation for the quadrotor via a convex optimization approach.The feasibility and effectiveness of the proposed method are verified by numerical simulations. | Lele XI Zhihong PENG Lei JIAO Ben M.CHEN | 2021 | Science China(Information Sciences)2021，64，7： | 0 |
| 14 | Novel perspective in transplantation therapy of mesenchymal stem cells:targeting the ferroptosis pathway显示文摘Ex vivo culture-amplified mesenchymal stem cells(MSCs)have been studied because of their capacity for healing tissue injury.MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells,but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period.Hence,strategies to increase the efficacy of MSC treatment are urgently needed.Iron overload,reactive oxygen species deposition,and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs,thereby hastening cell death.Notably,oxidative stress(OS)and deficient antioxidant defense induced by iron overload can result in ferroptosis.Ferroptosis may inhibit cell survival after MSC transplantation,thereby reducing clinical efficacy.In this review,we explore the role of ferroptosis in MSC performance.Given that little research has focused on ferroptosis in transplanted MSCs,further study is urgently needed to enhance the in vivo implantation,function,and duration of MSCs. | YUZHU XU PAN FAN LEI LIU XUANFEI XU LELE ZHANG JIADONG WANG YUAO TAO XIAOLONG LI XI LI YUNTAO WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 0 |
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