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| 1 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 2 | Development of a Powder Warming Compacting Machine with an Electrical Heating System显示文摘 | Lung C Y Fan K C Mou J | 2002 | Powder Technology2002，127，： | 1 |
| 3 | Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association con- ference on scientific issues related to definition 显示文摘 | Grundy SM Brewer HB Jr Cleeman JI Smith SC Jr Lenfant C American Heart Association National Heart Lung and Blood In- stitute | 2004 | Circulation2004，109，3： | 1 |
| 4 | Stability analysis and control synthesis for switched systems: A switched Lyapunov function approach显示文摘 | Daafouz J Riedinger P Lung C | 2002 | IEEE Trans on Automatic Control2002，47，11： | 1 |
| 5 | Chemical reclaiming of nickel sulfate from nickel bearing wastes 显示文摘 | Lung T N Lin J C Huang T C | 1983 | Conservation& Recycling1983，6，12： | 1 |
| 6 | Proximity and Localization of Corporate R&D Activities 显示文摘 | Carrincazeaux C Lung Y Rallet A | 2001 | Research policy2001，，30： | 1 |
| 7 | Estimating driving performance based on eeg spectrum analysis显示文摘 | LIN C T WU R C lUNG T P | 2005 | EURASIP Journal on Applied Signal Processing2005，，： | 1 |
| 8 | Stability analysis and control synthesis for switched systems: a switched Lyapunov function approach显示文摘 | Daafouz J Riedinger P Lung C | 2002 | IEEE Transactions on Automatic Control2002，47，11： | 1 |
| 9 | Proximity and Localisation of corporate R&D Activities显示文摘 | Carrincazeaux C Lung Y Rallet A | 2001 | Research Picy2001，30，5： | 1 |
| 10 | Results from the ALIVE study intensive 显示文摘 | Brun- Buisson C Minelli C Bertotini G et aI Epidemiology and outcome of acute lung injury in European in- tensive care units | 2004 | Care Med2004，30，1： | 1 |
| 11 | Proximity and Localization of corporate R&D activities显示文摘 | Carrincazeaux C Lung Y Rallet A | 2001 | Research Policy2001，30，5： | 1 |
| 12 | Diacylglycerol acyltransferase : A key mediator of plant triacylglycerol synthesis 显示文摘 | Lung S C Weselake R J | 2006 | Lipids2006，41，12： | 1 |
| 13 | Parental concerns based general developmental screening tool and autism risk:The Taiwan national birth cohort study显示文摘 | Lung F W Shu B C Chiang T L | | 0，，： | 1 |
| 14 | Promatug undergra- duate interest, preparedness, and professional pursuit in the sciences: An outcomes evaluation of the SURE program at Emory University 显示文摘 | lunge B Quinones C Kakietek J | 2010 | CBE Life Sei Edue2010，9，2： | 1 |
| 15 | Formalisation of a newprognosis model for supporting proactive maintenanceImplementation on industrial system 显示文摘 | Muller A Suhner M C lung B | 2008 | ReliabilityEngineering and System Safety2008，93，2： | 1 |
| 16 | Mental Symptoms in Different Health Professionals During the SARS At- tack : A Follow-up Study 显示文摘 | Lung F W Lu Y C Chang Y Y | 2009 | Psychiatr Q2009，80，2： | 1 |
| 17 | No dietary vitamin B12 required for juvenile tilapia Oreochromis niloticusxO, aureus显示文摘 | SHIAU S Y LUNG C Q | 1993 | Compara- tive Biochemistry and Physiology Part A: Physiology1993，105，1： | 1 |
| 18 | Invasion of human glioma cells is regulated by multiple chloride channels including clc-3 显示文摘 | LUIV C H I H LUNG SS I N S A I PU J KA N S | 2010 | Anticancer Res2010，30，11： | 1 |
| 19 | A two stage phase Ⅱ study显示文摘 | GRIDELLI C PERRONE F GALLO C Vinorelbineis well tolerated and active in the treatment of elderly patients with advanced non small cell lung cancer | 1997 | Eur J Cancer1997，33，： | 1 |
| 20 | Eu- trophication Analysis of Embayments in Prince William Sound Alaska 显示文摘 | Wu Song Lung James L Martin Steve C McCutcheon | 1993 | Journal of Environmental Engineering1993，119，5： | 1 |
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