|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 2 | Covalent incorporation of an aloxysilyl substituted faclerene derivative in sol gel matrixes显示文摘 | Monika A S Ndreas G A Klaus M K | 1997 | J Mater Chem1997，7，5： | 1 |
| 3 | Smart cities in Europe显示文摘 | A ndrea Carag l iu Chiara Del Bo PeterNijkamp | 2009 | Ideas2009，98，5： | 1 |
| 4 | Failing hemodialysis arteriovenous fistula and Peereutaneous treatment: imaging with CT, Mill and digital subtraction angiography 显示文摘 | Cavagna E DA' ndrea P Schiavon F | 2000 | Cardio Vas lnl Radiol2000，23，： | 1 |
| 5 | Ventricular interdependence in patients with dual chamberpacing: a Doppler tissue imaging study 显示文摘 | D'ndrea A Caso P Galderisi M | 2002 | Echocardiograpy2002，19，4： | 1 |
| 6 | Perspectives of women about ex- ternal breast pro6thezes 显示文摘 | Margaret I McAndrew A ndrea Harris A | 2012 | CONJ RCSIO Summer/Ere2012，223，10： | 1 |
| 7 | Air Transport and Tourism:Perspectives and Challenges for Destinations,Airlines and Govemments显示文摘 | Thomas B A ndreas W | | 0，，12： | 1 |
| 8 | Management of metastatic malignant thymoma with advanced radiation and chemotherapy techniques: report of a rare case 显示文摘 | D~ndrea MA Reddy GK | 2015 | World J Surg Oneol2015，13，1： | 1 |
| 9 | Perspectives of women about external breast prostheses显示文摘 | Margaret 1 McAndrew A ndrea Harris A | 2012 | Conj Rcsio Summer2012，223，10： | 1 |
| 10 | Confidencelost and Partially regained:Consumer response to food scares显示文摘 | A ndreas Boeker Claus-Henning Hanf | | 0，，： | 1 |
| 11 | Sensitivity and uncertainty analysis in patial modelling based on GIS 显示文摘 | Michele Crosetto Stefano Tarantola Ndrea Saltelli | 2000 | Agriculture Ecosystems and Environment2000，81，2： | 1 |
| 12 | Functional reinnerva- tion of the canine bladder after spinal root transection and immediate somatic nerve transfer 显示文摘 | Ruggieri MR Braverman AS D~ndrea L | 2008 | Neuretrauma2008，3，： | 1 |
| 13 | Numerical simulation and evaluation of velocity fluctuation during rotating stall of a centrifugal pump显示文摘 | NDREAS L GUNTHER B | 2011 | Journal of Fluids Engineering2011，133，8： | 1 |
| 14 | Risk of prostate cancer in men with spinal cord n jury: a systematic review and meta-analysis显示文摘 | Arcangelo Barbonetti Settimio D'ndrea Alessio Martorella Giorgio Felzani Sandro Francavilla Felice Francavilla | 2018 | Asian Journal of Andrology2018，20，6： | 0 |
| 15 | 两种热带树种在弱光条件下的生长和表型可塑性显示文摘根据耐荫性筛选热带雨林树种,对于在次生林富集区域中更有效地管理具有经济意义的本土树种非常重要。本研究旨在确定全株的光补偿点,比较弱光条件下Cariniana legalis和Gallesia integrifolia幼苗生长和碳分配有关的表型可塑性。实验所用幼苗在5种光合有效辐射条件下(0.02、1.1、2.3、4.5和5.9 mol photons m^(−2)day^(−1))培养77天,设置3个重复,并分析了生长和碳分配变量指标。结果显示,在1.1 mol photons m^(−2)day^(−1)条件下,C.legalis的生长速率高于G.integrifolia,而在5.9 mol photons m^(−2)day^(−1)条件下,C.legalis的生长速率低于G.integrifolia。不同物种间的光补偿点差异显著。根据耐阴分类标准对这两种热带树种进行分类,我们的研究结果表明,C.legalis相对较低的光补偿点和表型可塑性与生长速率有关,比G.integrifolia具有更强的耐荫性。从实际的角度来看,我们证明了两种树种之间生长和光合有效辐射变化的不同关系可以成为在森林丰富工程中比较和选择种植树种的可行工具。 | Marúcia da Cunha Fagundes Ândrea Carla Dalmolin Luciana Santos Lobo Ana Cristina Schilling Martielly Santana dos Santos Marcelo Schramm Mielke | 2021 | Journal of Plant Ecology2021，14，2： | 0 |
| 16 | 【原创论文】他达拉非治疗有血管风险的ED男性对改善内皮细胞损伤和修复效果不明显显示文摘循环成血管细胞数(CACs)与来源于循环单核细胞的集落形成单位数(CFUs)在实验室检测中代表内皮细胞的修复能力。具有血管危险因素(VRF)的ED男性血清中内皮细胞损伤/功能障碍的标志物水平增加以及来源于健康男性的循环成血管细胞数和集落形成单位数减少。我们研究了选择性磷酸二酯酶5抑制剂他达拉非能否改善有VRF的ED男性内皮细胞的修复能力以及减少血清内皮细胞损伤/功能障碍标志物的水平。36例ED患者的20%血清培养健康男性的单核细胞以检测循环成血管细胞和集落形成单位。检测JED患者服用他达拉非(隔日20毫克)及安慰剂前及用药4周后的血清标志物。他达拉非治疗能改善勃起功能(P=0.0028),但不能减轻ED患者的血清对健康男性的CACs和CFUs的抑制。与基线及安慰剂比较,治疗后内皮素.1的水平(P=0.011)和组织型纤溶酶原激活物(P=0.005)均减少,而E-选择素水平无变化。有血管危险因素的ED患者经他达拉非治疗后实验室检测内皮细胞损伤与修复能力显示只有轻微影响。PDE5抑制剂对血管稳态的可能益处尚需进一步研究。 | Fiore Pelliccione Anatolia D'ngeli Settimio D'ndrea Arcangelo Barbonetti Alfonso Pezzella Stefano Necozione Stefano Falone Fernanda Amicarelli Felice Francavilla Sandro Francavilla | 2014 | Asian Journal of Andrology2014，16，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员