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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Synthesis and characterization of asbestos-silane hybrid materials 显示文摘 | Onal Y Yakinci E SeckinT Iqduygu M G | 2005 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2005，255，1321： | 1 |
| 3 | A new flowsheet for processing chromite fines by column flotation and the collector adsorption mechanism 显示文摘 | Gunry A Onal G Celik M S | 1999 | Minerals Engineering1999，12，9： | 1 |
| 4 | Flotation of Aladag- oxide lead-zinc ores显示文摘 | ONAL G BULUT G G L A KANGAL 0 PEREK K T ARSLAN F | 2005 | Minerals Engineering2005，18，2： | 1 |
| 5 | Studies on the applicability of alginate-entrapped Chryseomonas luteola TEM 05 for heavy metal biosorption 显示文摘 | Onal S Baysal S H Ozdemir G | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 6 | What is the impact of HelicobaCter pylori density on the success f eradication therapy:a clinico-histopathological study显示文摘 | Onal IK Gokcan B Benzer E Bilir G Oztas E | 2013 | Clin Res Hepatol Gastroenterl2013，37，64： | 1 |
| 7 | Beneficiation of colenranite tailings by attrition and flotation 显示文摘 | Gul A Kaytaz Y Onal G | 2006 | Minerals Engineenng2006，19，： | 1 |
| 8 | Numerical analyses of piles subjected to lateral soil movement显示文摘 | KAHYAOGLU M R IMANCLI G ONAL O | 2012 | Journal of Civil Engineering2012，16，4： | 1 |
| 9 | Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study显示文摘 | Onal H Keskindemirci G Adal E | 2012 | J Pediatr Endocrinol Metab2012，25，78： | 1 |
| 10 | Flotation of Aladag oxide lead - zinc ores 显示文摘 | Onal G Bulut G Giil A | 2005 | Minerals Engineering2005，18，： | 1 |
| 11 | Effects of selenium supplemen- tation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study 显示文摘 | Onal H Keskindemirci G Adal E | 2012 | J Pediatr Endocrinol Metab2012，25，78： | 1 |
| 12 | A new and direct method for the trace element determination in cauliflower by differential pulse polarography显示文摘 | Somer G Onal U | 2004 | Talanta2004，62，： | 1 |
| 13 | A new flowsheet for processing chromite fines by column flotation and the collector adsorption mechanism显示文摘 | Gunry A onal G Celik M S | 1999 | Minerals Engineering1999，12，9： | 1 |
| 14 | Beneficiation of Colemanite Tailings by Attrition and Flotation显示文摘 | Gul A Kaytaz Y Onal G | 2006 | Minerals Engineering2006，19，： | 1 |
| 15 | Prostate mucinous carcinoma treated with definitive radiotherapy and hor- monal therapy: case report and review of the literature 显示文摘 | Guler O C Onal C Erbay G | 2014 | Clin Genitourin Cancer2014，12，2： | 1 |
| 16 | A New Process for Upgrading Boron Content and Recovery of Borax Concetrate 显示文摘 | Acarkan N Btdut G Kangal O Onal G | 2005 | Minerals Engineering2005，18，： | 1 |
| 17 | Prostate mucinous carcinoma treated with definitive radiotherapy and hor- moe显示文摘 | Guler O C Onal C Erhay G | 2014 | Clin Genitourin Cancer2014，12，2： | 1 |
| 18 | Flotation of Aladag oxide leadzinc ores显示文摘 | Onal G Bulut G Gift A | 2005 | Minerals Engineering2005，18，2： | 1 |
| 19 | Comparsion of conventional and CTbased planning for i nteracavitary brachytherapy for cervical cancer:target volume coverage and oragnas at risk doses显示文摘 | Onal C Arslan G Topkan E | 2009 | J Exp Clin Cancer Res2009，28，： | 1 |
| 20 | Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study显示文摘 | Onal H Keskindemirci G Adal E | 2012 | J Pediatr Endocrinol Metab2012，25，78： | 1 |
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