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| 1 | Revisions to the Tumor,Node,Metastasis staging of lung cancer(8th edition):Rationale,radiologic findings and clinical implications显示文摘The Tumor, Node, Metastasis(TNM) staging system,adopted by the Union for International Cancer Control(UICC) and the American Joint Committee on Cancer(AJCC), has been recently revised, with the new 8^(th) edition of the staging manual being published in January 2017. This edition has few but important evidencebased changes to the TNM staging system used for lung cancer. Radiologists should be aware of the updated classification system to accurately provide staging information to oncologists and oncosurgeons. In this article, we discuss the rationale, illustrate the changes with relevance to Radiology, and review the clinical implications of the 8^(th) edition of the UICC/AJCC TNM staging system with regards to lung cancer. | Fernando U Kay Asha Kandathil Kiran Batra Sachin S Saboo Suhny Abbara Prabhakar Rajiah | 2017 | World Journal of Radiology2017，9，6： | 39 |
| 2 | Alternative splicing as a biomarker and potential target for drug discovery显示文摘其他的拼接在 pre-mRNA 成熟期间是 multi-exonic 基因表示的一个关键过程。在这个过程,基因的特别 exons 将被包括在以内或从最后的成熟 mRNA,和产生抄本排除了产生多样的蛋白质 isoforms。最近的证据证明有多重 exons 的约 95% 人的基因经历在 pre-mRNA 成熟期间的其他的拼接。因此,其他的拼接在生理的进程和房间开发程序起一个关键作用,其他的拼接的 and.dysregulation 高度与人的疾病被联系例如癌症,糖尿病和 neurodegenerative 疾病。在这评论,我们讨论其他的拼接的规定,检验在其他的拼接和人的疾病之间的关系,并且描述修改其他的拼接的几条途径,它能帮助人的疾病诊断和治疗。 | Kai-qin LE Bellur S PRABHAKAR Wan-jin HONG Liang-cheng LI | 2015 | Acta Pharmacologica Sinica2015，36，10： | 4 |
| 3 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 4 | Synthesis and QSAR studies on thiazolidinones as anti-HIV agents 显示文摘 | Rawal R K Solomon V R Prabhakar Y S | 2005 | Comb Chem High Throughput Screen2005，8，5： | 1 |
| 5 | An introduction to biometricrecognition显示文摘 | Jain A K Ross A Prabhakar S | 2004 | IEEE Transactions on Circuits and Systems forVideo Technology2004，14，1： | 1 |
| 6 | Fast-track surgery:Toward comprehensive peri-operative care显示文摘 | Nanavati AJ Prabhakar S | 2014 | Anesth Essays Res2014，8，2： | 1 |
| 7 | An introduction to biometric recognition显示文摘 | JAIN A K ROSS A PRABHAKAR S | 2004 | IEEE Transactions on Circuits and Systems for Video Technology2004，14，1： | 1 |
| 8 | Application of Discrete Wavelet Transform for Detection of Ball Bearing Race Fault显示文摘 | Prabhakar S Mohanty A R Sekhar A S | 2002 | Tribology International2002，35，12： | 1 |
| 9 | Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry 显示文摘 | Garcia A Prabhakar S Brock CJ | 2004 | Proteomics2004，4，3： | 1 |
| 10 | Biometric recognition:Secur-ity and privacy concerns 显示文摘 | Prabhakar S Pankanti S Jain A K | 2003 | IEEE Security Privacy2003，1，2： | 1 |
| 11 | 2-(Aryl)- 3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors显示文摘 | Rawal R K Prabhakar Y S Katti S B | 2005 | Bioorg Med Chem2005，13，24： | 1 |
| 12 | Query Indexing and Velocity Constrained Indexing:Scalable Techniques for Continuous Queries on Moving Objects显示文摘 | Prabhakar S Xia Y Kalashnikov D | 2002 | IEEE Transactions on Computers2002，51，10： | 1 |
| 13 | Rights protection for relational data显示文摘 | SION R ATALLAH M PRABHAKAR S | 2004 | IEEE Transactions on Knowledge And Data Engineering2004，16，6： | 1 |
| 14 | Evaluation of serum vascular endothelial growth factor(VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast 显示文摘 | Shivakumar S Prabhakar BT Jayashree K | 2009 | Cancer Res Clin Oncol2009，135，4： | 1 |
| 15 | Filterbank-based fingerprint matching显示文摘 | JAIN A PRABHAKAR S LIN Hong | 2000 | IEEE Trans on Image Processing2000，9，5： | 1 |
| 16 | Filterbank-based fingerprint matching显示文摘 | Jain A K Prabhakar S Hong L | 2000 | IEEE Transactions on Image Processing2000，9，5： | 1 |
| 17 | Comparative evaluation of the remineralising effects and surface microhardness of glass ionomer cement containing grape seed extract and casein phospho-peptide- amorphous calcium phosphate: an in vitro study显示文摘 | Prabhakar AR Sharma D Sugandhan S | 2012 | Eur Arch Paediatr Dent2012，13，3： | 1 |
| 18 | Randomized Gossip A1 gorithms显示文摘 | Boyd S Ghosh A and Prabhakar B | 2006 | IEEE Transactions on Information Theory2006，52，6： | 1 |
| 19 | An introduction to biometric recognition 显示文摘 | JAIN A K ROSS A PRABHAKAR S | 2004 | IEEE Transactions on Circuit and System for VideoTechnology2004，14，1： | 1 |
| 20 | The alkaloids of Portuguese ergot显示文摘 | LOBO A M PRABHAKAR S BENITO-RODRIGUEZ A M | 1981 | Rev Port Quim1981，23，： | 1 |
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