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| 1 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 2 | Study on spectroscopic characterization of meso-tetrakis (4-hydroxyphenyl) porphyrin (THPP) in β-cyclodextrin and its derivatives 显示文摘 | Guo X An W Shuang S | 2005 | Journal of Photochemistry and Photobiology A: Chemistry2005，173，： | 1 |
| 3 | Effects of matrine on HepG2 cell proliferation and expression of tumor relevant-proteins in vitro显示文摘 | Qin XG Hua Z Shuang W | | 0，，03： | 1 |
| 4 | Adenovirus technology for gene manipulation and function studies显示文摘 | Yinbin W Shuang H | 2000 | Drug Discovery Today2000，5，： | 1 |
| 5 | A Sensitivi-ty Model(SM)Approach to Analyze Urban Developmentin Taiwan Based on Sustainability Indicators显示文摘 | Shuang Shuli Yeh C T Budd W W | 2009 | Envi-ronmental Impact Assessment Review2009，29，2： | 1 |
| 6 | Numerical Simulation of Supercoo- ling Processand Frazil Ice Evolution显示文摘 | Shuang M W Doering J C | 2005 | Journal of Hydraulic Engineering2005，131，10： | 1 |
| 7 | Effect of Microscopic Environment on the Self-Stacking Binding of Porphyrin to DNA显示文摘 | An W T Guo X L Shuang S M Dong C | 2005 | Journal of Photochemistry and Photobiology A Chemistry2005，173，： | 1 |
| 8 | SPElHPLC/UV Studies on Acrylamide in Deep-fried Flour-based Indigenous Chinese Foods显示文摘 | Wang H Y Lee A W M Shuang S M | 2008 | MicrochemJ2008，89，： | 1 |
| 9 | BMP -2 exerts differential effects on differentiation of rabbit bone marrow stromal cells grown in two - dimensional and three - dimensional systems and is required for in vitro bone formation in a PLGA scaffold显示文摘 | sHuang W Carlsen B Wulur I | 2004 | Exp Cell Res2004，2，： | 1 |
| 10 | A novel ratiometric emission probe for Caz+ in living cells显示文摘 | Liu Q Bian W Shi H Fan L Shuang S Dong C Choi MMF | 2013 | Org Biomol Chem2013，11，： | 1 |
| 11 | Effects of Matrine on HepG2 cell proliferation and expression of tumor relevant proteins in vitro显示文摘 | Qin XG Hua Z Shuang W | 2010 | Pharm Biol2010，48，3： | 1 |
| 12 | Curcumin produces antidepressant effects via activating MAPK/ERK-de- pendent brain-derived neurotrophic factor expression in the amygdala of mice 显示文摘 | Zhang L Xu T Shuang W | 2012 | Behav Brain Res2012，235，1： | 1 |
| 13 | Study on terphenyl isomers second-derivative solid-substrate room temperature phosphorescence显示文摘 | DONG C SHUANG S M JIN W J | 1999 | Analytical Letter1999，32，5： | 1 |
| 14 | Three-dimensional modeling of the pelvic floor support systems of subjects with and without pelvic organ prolapse显示文摘 | Shuang R Bing X Jianliu W | 2015 | Biomed Res Int2015，2015，84： | 1 |
| 15 | Adenovirus technology for gene manipulation and function studies显示文摘 | Yinbin W Shuang H | 2000 | Drug Discovery Today2000，5，： | 1 |
| 16 | Biosensors and Bioelectronics显示文摘 | Dong W J Dong C Shuang S M Choi M M F | 2010 | 25:10432010，25，： | 1 |
| 17 | Effects of matrine on HepG2 cell proliferation and expression of tumor relevant-proteins in vitro 显示文摘 | Qin XG Hua Z Shuang W | 2010 | Pharm Biol2010，48，3： | 1 |
| 18 | New antiviral cassane furanoditerpenes from Caesalpinia minax 显示文摘 | Ren W J Shuang C M Paul P | 2001 | J Nat Prod2001，64，： | 1 |
| 19 | Poincare Sphere Method for Optimizing the Wavelength Converter Based on Nonlinear Polarization Rotation in Semiconductor Optical Amplifiers 显示文摘 | SHUANG Z CHONGQING W MU C | 2009 | IEEE Journal of Quan- tum Electronics2009，45，8： | 1 |
| 20 | Lens design of LED searchlight of high brightness and distant spot显示文摘 | SHUANG Z KAI W FEI C | 2011 | Journal of the Optical Society of America A2011，28，5： | 1 |
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