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| 1 | 聚丙交酯复合乙交酯微球经肝动脉化疗栓塞术治疗肝癌的动物实验显示文摘目的 :在肝细胞癌动物模型上观察聚丙交酯复合乙交酯 (PLcG)微球经肝动脉化疗栓塞术 (TACE)治疗肝癌的疗效。方法 :在雄性ACI大鼠 ( 15例 )肝包膜下植入MorrisHepatoma 392 4A肝癌小瘤块 ( 1mm3) ,移植术后 13天时行磁共振检查。再经正中腹切开术和经胃十二指肠动脉逆行插管进行以下介入治疗 :治疗组A( 40mgPLcG + 0 .0 5mg丝裂霉素 ,4例 )、对照组B( 0 .0 5mg丝裂霉素 + 0 .0 4mg碘化油 +肝动脉结扎 ,4例 )和对照组C( 1.5ml生理盐水 ,7例 )。插管术后 13天再次行磁共振术观察肝肿瘤体积变化。结果 :在C组 ,肿瘤体积在实验期间增长 2 7.12倍 ,在B组 ,肿瘤体积增长 3.76倍 ,而在A组 ,肿瘤体积仅增长 2 .87倍。A组与C组肿瘤体积增长率在t检验时均有显著性差异 (P <0 .0 5 )。结论 :在动物实验中将PLcG微球运用于TACE可明显抑制肝肿瘤生长。 | 钱骏 冯敢生 TruebenbachJ Pereira PL Huppert PE Graepler F Eul T Claussen CD | 2001 | 放射学实践2001，16，6： | 4 |
| 2 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 3 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production显示文摘 | Edgerton D S Jacobson P B Opgenorth T Jet cd | 2006 | Metabolism2006，55，9： | 1 |
| 6 | Mechanism of polyamine action during senescence responses induced by osmotic stress显示文摘 | Tibureio A F Besford R T Capell T et cd | 1994 | J Exp Bot1994，45，： | 1 |
| 7 | Protection from Fasmediated apoptosis by a soluble form of the Fas molecule显示文摘 | Chen JH Zhou T Liu CD | 1994 | Science1994，263，： | 1 |
| 8 | Inflammatory mark- ers, adiponectin, and risk of type 2 diabetes in the Pima Indian显示文摘 | Krakoff J Funahashi T Stehouwer CD | 2003 | Diabetes Care2003，26，6： | 1 |
| 9 | Structure of cer- ebral arterioles in cystathionine - synthase - deficient mice显示文摘 | Baumbach GL Sigmund CD Bottiglieri T | 2002 | Circ Res2002，91，10： | 1 |
| 10 | Phase Ⅱ study of gefitinib, flu orouracil, leueovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer显示文摘 | Kuo T Cho CD Halsey J | 2005 | J Clin Oncol2005，23，24： | 1 |
| 11 | A phase Ⅱ study of gefitinib in combination with FOLFOX-4(IFOX) in patient s with metastatic colorectal cancer显示文摘 | Fisher GA Kuo T Cho CD | 2004 | Proc Am Soc Clin Oncol2004，22，14： | 1 |
| 12 | Fixation of proximal humerus fractures using the PHILOS plate:early experience显示文摘 | Koukakis A Apostolou CD Taneja T | 2006 | Clin Orthop Relat Res2006，422，1： | 1 |
| 13 | Changes of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis显示文摘 | Aotake T Lu CD Chiba Y | 1999 | Clin Cancer Res1999，5，1： | 1 |
| 14 | ARC1 is an E3 ubiquitin ligase and promotes the ubiquitination of proteins during the rejection of self-incompatible Brassica pollen 显示文摘 | Stone S L Anderson E M Mullen R T et cd | 2003 | Plant Cell2003，15，4： | 1 |
| 15 | Health outcomes associated with various antihypertensive therapies used as first-line agents显示文摘 | Psaty BM Lumley T Furberg CD | 2003 | JA- MA2003，289，19： | 1 |
| 16 | Non-invasive imaging of combretastatin ac- tivity in two tumor models: association with invasive estimates 显示文摘 | Nielsen T Murata R Maxwell R J Stedkilde-Jorgensen H Oster- gaard L Ley CD etal | 2010 | Acta Oncol2010，49，7： | 1 |
| 17 | S100P:a novel therapeutic target for cancer显示文摘 | Arumugam T Logsdon CD | | 0，，04： | 1 |
| 18 | Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements显示文摘 | Branham WS Melvin CD Han T | 2007 | BMC Biotech2007，7，1： | 1 |
| 19 | Assessing heavy metal contamination in Sado Estuary sediment:an index analysis approach 显示文摘 | Caeiro S Costa M H Ramos T B et cd | 2005 | Ecological Indicators2005，，5： | 1 |
| 20 | Structure of cere- bra arterloles in cystathionine beta-synthase-deficient mice 显示文摘 | Baumbach GL Sigmund CD Bottiglieri T | 2002 | Circ Res2002，91，10： | 1 |
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