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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | The shaft resistance of axially loaded Piles in clay 显示文摘 | Potts D M Mas'tins J P | 1982 | Geotechnique1982，32，4： | 1 |
| 4 | Limita tion of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | WALDRON J TIN M M KELLER A | 2003 | Radiother Oncol2003，68，： | 1 |
| 5 | A randomized controlled trial to compare steroid with cyclosporine for theopical treatment of oral lichen planus显示文摘 | Yoke PC Tin GB Kim M J | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
| 6 | Directional solidification of large superalloy castings with radiation and liquid-metal cooling:a comparative assessment显示文摘 | Elliott A J Tin S Pollock T M | 2004 | Metallurgical and Materials Transactions A2004，35，： | 1 |
| 7 | Silylation and surface properties of chemi- cally grafted hydrophobic silica显示文摘 | CAPEL-SANCHEZ M C BARRIO L CAMPOS-MAR- TIN J M | 2004 | Journal of Colloid and Interface Science2004，277，1： | 1 |
| 8 | Modelling hot deformation of Inconel 718 using state variables 显示文摘 | ZHAO X GUEST R P TIN S COLE D BROOKS J W PEERS M | 2004 | Materials Science and Technology2004，20，： | 1 |
| 9 | Directional solidification oflarge superalloy castings with radiation and liquid-metal cooling: acomparative assessment 显示文摘 | Elliott A J Pollock T M Tin S | 2004 | Metallurgical and Materials TransactionsA2004，35，： | 1 |
| 10 | Syntheses, structures and properties of seven isomorphous ] D Ln3 complexes Ln (BTA) (HCOO) (H20)3(H2BTA = bis(tetrazoly)amine, Ln = Pr, Gd, Eu, Tb, Dy, Er, Yb) and two 3D Lna complexes Ln (HCOO) 3 ( Ln =Pr, Nd) 显示文摘 | tin J M Guan Y F Wang D Y | 2008 | Dalton Transactions2008，，： | 1 |
| 11 | The influence of cooling rate from temperatures above the γ'solvus on morphology,mismatch and hardness in advanced polycrystalline nickel-base superalloys显示文摘 | Mitchell R J Preuss M Tin S | 2008 | Materials Science and Engineering A2008，473，： | 1 |
| 12 | Evaluation of a handheld clinical decision support tool for evidence-based learning and practice in medical undergraduates 显示文摘 | JOHNSTON J M LEUNG G M TIN K Y K etc | 2004 | Medical Education2004，38，6： | 1 |
| 13 | Directional Solidification of Large Superalloy Castings With Radiation and LiquidMetal Cooling: A Comparative Assessment 显示文摘 | Elliott A J Pollock T M Tin S | 2004 | Metallurgical and Materials Transactions2004，35，10： | 1 |
| 14 | Increased oxidative and nitxative stress acceler- ates aging of the retinal vasculature in the diabetic retina 显示文摘 | LAMOKE F SHAW S YUAN J ANANTH S DUNCAN M MAR- TIN P | 2015 | PLoS Owe2015，10，01： | 1 |
| 15 | Materials Science andEngineering A显示文摘 | Mitchell R J Preuss M Tin S | 2008 | 2008, 473: 1582008，473，： | 1 |
| 16 | Directional solidification of large superalloy castings with radiation and liquid-metal cooling:A comparative assessment显示文摘 | ELLIOTT A J TIN S KING W T HUANG S C GIGLIOTTI M F X POLLOCK T M | 2004 | Metallurgical and Materials Transactions A2004，35，10： | 1 |
| 17 | A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus 显示文摘 | Yoke PC Tin GB Kim M J | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
| 18 | A unified hypothesis on the lineage of neural stem cells 显示文摘 | ALVAREZ-BUYLLA A GARCLA-VERDUGO J M TRAMON- TIN A D | 2001 | Nat Rev Neurosci2001，2，： | 1 |
| 19 | Residual stresses in a quenched superalloy turbine disc: Measurements and mode- ling 显示文摘 | Rist M A James J A Tin S | 2006 | Metall Mater Trans A2006，37，2： | 1 |
| 20 | A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus 显示文摘 | Yoke PC Tin GB Kim M J | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
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