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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Design and Testing of a Dual--path Front Hydrostatic Drive bywire Control System for an Off road Vehicle显示文摘 | Lumkes J H van Doom W | 2008 | Transactions of the ASABE2008，51，4： | 1 |
| 3 | Representation of Local Geometry in the Visual System 显示文摘 | Koenderink J J Van Doom A J | 1987 | Biological Cybernetics (S0340-1200)1987，55，： | 1 |
| 4 | Magic traits in speciation:‘magic' but not rare显示文摘 | Servedio MR Van Doom GS Kopp M Frame AM Nosil P | | 0，，： | 1 |
| 5 | Aberrant DNA methylation in cutaneous malignancies显示文摘 | van Doom R Gruis NA Willemze R | 2005 | Semin Oncol2005，32，5： | 1 |
| 6 | Clarithromy ein-susceptible an resistant Helicobacter pylori isolates with identical randomly amplified polymorphic DNA-PCR genotype cuhure from single gastric biopsy specimens prior to antibiotic therapy 显示文摘 | Van der Ende A Van Doom LT Rooijakkers S | 2001 | J Clin Microbio12001，39，7： | 1 |
| 7 | Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid,other drug resistance,and suc-cessful transmission of Mycobacterium tuberculosis in the Nether-lands显示文摘 | van Soolingen D de Haas PEW van Doom HR | 2000 | J Infect Dis2000，182，6： | 1 |
| 8 | Distinguishing acute-onset CIDP from Guillain Barr syndrome with treatment related fluctuations显示文摘 | Ruts L van KR van Doom PA | 2005 | Neurology2005，12，65： | 1 |
| 9 | Invariant properties of the motion parallax field due to the movement of rigid bodies relative to an observer显示文摘 | Koenderink J J van Doom A J | 1975 | Optica Acta1975，22，9： | 1 |
| 10 | Non-islet cell tumour-in- duced hypoglycaemia: a review of the literature including two new cases 显示文摘 | Groot JW Rikhof B van Doom J | 2007 | Endocr Relat Cancer2007，14，4： | 1 |
| 11 | Ex- pression of osteotrepic growth factors and growth hormone receptor in a canine distraction osteogenesis model 显示文摘 | Theyse LF Oostedaken- Dijksterhuis MA van Doom J | 2006 | J Bone Miner Metah2006，24，4： | 1 |
| 12 | Dietary flavonoids induce MLL translocations in primary human CD34^ + cells 显示文摘 | Sahar Barjesteh van Waalwijk van Doom - Khosrovani Janssen J Maas L M | 2007 | Carcinogenesis2007，28，8： | 1 |
| 13 | Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery显示文摘 | Han-Geurts IJ Van Geel AN Van Doom L | 2006 | Eur J Surg Oncol2006，32，10： | 1 |
| 14 | IVIg treatment and prog- nosis in Guillain-Barre syndrome 显示文摘 | van Doom PA Kuitwaard K Walgaard C | 2010 | J Clin Immunol2010，30，1： | 1 |
| 15 | The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor 1-alpha and GLUT-1 in non-small cell lung cancer 显示文摘 | Van Baardwijk A Dooms C Van Suylen R J | 2007 | Eur J Cancer2007，43，： | 1 |
| 16 | Sepsis-related acture kid- ney injury : A protective effect of drotrecogin alpha ( activated treat- ment 显示文摘 | Janssen van Doom K spapen H | 2008 | Acta Anaesthesiol scand2008，52，9： | 1 |
| 17 | Critical illness polyneuropathy and myopathy (CIPNM): evidence for local immune activation by cytokine-expression in the muscle tissue显示文摘 | De Letter MA van Doom PA Savelkoul HF | 2000 | J Neuroimmunol2000，106，： | 1 |
| 18 | Physiology and molecular biology of petal senescence 显示文摘 | van Doom W G Wohering E J | 2008 | Journal of Experimental Botany2008，59，3： | 1 |
| 19 | Systematic Error Estimation in Multisensor Fusion Systems显示文摘 | van Doom | 1995 | SPIE1995，，： | 1 |
| 20 | Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment显示文摘 | Van Doom LJ Schneeberger PM Nouhan N | 2000 | Gut2000，46，3： | 1 |
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