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	题名	作者	年代	出处	被引量
1	Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery.	Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen	2008	World Journal of Gastroenterology2008，14，45：	4
2	Aquantitative assay for the number of murine lymphoma cells capable of proliferationin vivo 显示文摘	Bruce WR Van Der Gaag H	1963	Nature1963，199，：	1
3	Aspirin plus coumarin versus aspirin alone in the prevention of reocclusion after fibrinolysis for acute myocardial infarction:results of the Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis (APRICOT)-2 Trial显示文摘	Brouwer MA van den Bergh PJ Aengevaeren WR	2002	Circulation2002，106，6：	1
4	A quantitative assay for the number of murine lymphoma cells capable of proliferation in vivo 显示文摘	BRUCE WR VAN DER GAAG H	1963	Nature1963，199，：	1
5	Analysis of patients with poor outcome of rectocele repair 显示文摘	Van Dam JH Hop WC Schouten WR	2000	Dis Colon Rectum2000，43，11：	1
6	Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation显示文摘	Farid WR Pan Q van der Meer AJ	2012	Liver Transpl2012，18，3：	1
7	Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability显示文摘	Licausi F Weits DA Pant BD Scheible WR Geigenberger P van Dongen JT		0，，：	1
8	Lectin complementpathway gene profile of donor and recipient determine the risk ofbacterial infections after orthotopic liver transplantation 显示文摘	DeRooij BF Van Hoek B Ten Hove WR	2010	Hepatol2010，52，3：	1
9	Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain显示文摘	Van Err MN Easterday WR Simonson TS	2007	J Clin Microbiol2007，45，1：	1
10	Cabazitaxelin patients with metastatic castration-resistant prostate cancer:results of a compassionate use program in the Netherlands 显示文摘	Wissing MD van Oort IM Gerritsen WR	2013	Clin Genitourin Cancer2013，11，：	1
11	Localization and quantification of regional and segmental air trapping in asthma显示文摘	Cohen J Douma WR van Ooijen PM Willems TP Dicken V Kuhnigk JM		0，，：	1
12	Perspectives on allergen-specific immunotherapy in childhood: an EAACI position statement 显示文摘	Calderon MA van Gerth WR Eichler I	2012	Pediatr Allergy Immunol2012，23，4：	1
13	Experimental nephrolithiasis in rats: the effect of ethylene glycol and vitamin D3 on the induction of renal calcium oxalate crystals显示文摘	De WR Boeve ER Van MPP	1996	Scanning Microsc1996，10，2：	1
14	Vision function in HIV-infected individuals without retinitis: report of the Studies of Ocular Complications of AIDS Research Group 显示文摘	freeman WR van Natta ML Jabs D	2008	Am J Ophthalmol2008，145，3：	1
15	Incidence of and risk factors for complications associated with halo- vest immobilization:a prospective,descriptive cohort study of 239 patients显示文摘	van Middendorp JJ Slooff WB Nellestein WR	2009	J Bone Joint Surg Am2009，91，1：	1
16	Vision Function inHIV-infected individuals without retinitis:report of the Studiesof Ocular Complications of AIDS Research Croup 显示文摘	Freeman WR Van Natta ML Jabs D	2008	Am JOphthalmol2008，145，：	1
17	A case series: evaluation of the metaholic salty of aripiprazole显示文摘	De Hert M Hanssens L van WR	2007	Schizophr Bull2007，33，3：	1
18	Start up of reactors for anoxic ammonium oxidation: experiences from the firstfuU scale anammox reactor in Rotterda 显示文摘	Van der Star WRL Abma WR Blommers D	2007	Water Research2007，41，18：	1
19	Ligation of theintersphincteric fistula tract in low transsphincteric fistula : anew technique to avoid fistulotomy 显示文摘	Van Onkelen RS Gosselink MP Schouten WR	2013	Colorectal Dis2013，15，：	1
20	Extensive chimerism in liv- er transplants: vascular endothelium, bile duct epithelium, and hepa- tocytes显示文摘	Hove WR van Hock B Bajema IM	2003	Liver Transpl2003，9，6：	1

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