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| 1 | Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial显示文摘 | Ilfet Songun Hein Putter Elma Meershoek-Klein Kranenbarg Mitsuru Sasako Cornelis JH van de Velde | 2010 | Lancet Oncology2010，，5： | 20 |
| 2 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 3 | N-terminal truncated RHT-1 proteins generated by translational reinitiation cause semi-dwarfing of wheat Green Revolution alleles显示文摘The unprecedented wheat yield increases during the Green Revolution were achieved through the introduc-tion of the Reduced height(Rht)-B1b and Rht-D1b semi-dwarfing alleles.These Rht-1 alleles encode growth-repressing DELLA genes containing a stop codon within their open reading frame that confers gibberellin(GA)-insensitive semi-dwarfism.In this study,we successfully took the hurdle of detecting wild-type RHT-1 proteins in different wheat organs and confirmed their degradation in response to GAs.We further demonstrated that Rht-B1b and Rht-D1b produce N-terminal truncated proteins through trans-lational reinitiation.Expression of these N-terminal truncated proteins in transgenic lines and in Rht-D1c,an allele containing multiple Rht-D1b copies,demonstrated their ability to cause strong dwarfism,resulting from their insensitivity to GA-mediated degradation.N-terminal truncated proteins were detected in spikes and nodes,but not in the aleurone layers.Since Rht-B 1b and Rht-D1b alleles cause dwarfism but have wild-type dormancy,this finding suggests that tissue-specific differences in translational reinitiation may explain why the Rht-1 alleles reduce plant height without affecting dormancy.Taken together,our findings not only reveal the molecular mechanism underlying the Green Revolution but also demonstrate that trans-lational reinitiation in the main open reading frame occurs in plants. | Karel Van De Velde Stephen GThomas Floor Heyse Rim Kaspar Dominique Van Der Straeten Antje Rohde | 2021 | Molecular Plant2021，14，4： | 8 |
| 4 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 5 | Differences in outcomes of oesophageal and gastric cancer surgery across Europe显示文摘 | J. L. Dikken J. W. van Sandick W. H. Allum J. Johansson L. S. Jensen H. Putter V. H. Coupland M. W. J. M. Wouters V. E. P. Lemmens C. J. H. van de Velde | 2012 | Br J Surg2012，，1： | 4 |
| 6 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 7 | The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma显示文摘 | Koen C.M.J. Peeters Corrie A.M. Marijnen Iris D. Nagtegaal Elma Klein Kranenbarg Hein Putter Theo Wiggers Harm Rutten Lars Pahlman Bengt Glimelius Jan Willem Leer Cornelis J.H. van de Velde | 2007 | Annals of Surgery2007，，5： | 3 |
| 8 | Extended lymph node dissection for gastric cancer:who may benefit?Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | | 0，，11： | 3 |
| 9 | 前十字韧带在维持膝关节稳定性上的重要性显示文摘前十字韧带(anterior cruciate ligament,ACL)是膝关节的四条主要韧带之一,其功能是与膝关节内部及周围的其他解剖结构共同维持膝关节的静态和动态平衡。ACL具有复杂的三维结构,传统上将ACL分为两束,前内侧束和后外侧束…,是以韧带在胫骨上的插入方向命名的(图1)。ACL起始于胫骨髁间隆起的前区,延伸至股骨髁间窝后外侧。 | Samuel K. Van de Velde Thomas J. Gill 李国安 | 2007 | 中华骨科杂志2007，27，11： | 3 |
| 10 | Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients显示文摘 | J.J. Bonenkamp I. Songun K. Welvaart C.J.H. van de Velde J. Hermans M. Sasako J.T.M. Plukker P. van Elk H. Obertop D.J. Gouma C.W. Taat J. van Lanschot S. Meyer P.W. de Graaf M.F. von Meyenfeldt H. Tilanus | 1995 | The Lancet . 1995 (8952)1995，，： | 2 |
| 11 | Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial 1显示文摘 | H.H Hartgrink C.J.H van de Velde H Putter I Songun M.E.T Tesselaar E.Klein Kranenbarg J.E de Vries J.A Wils J van der Bijl J.H.J.M van Krieken | 2004 | European Journal of Surgical Oncology2004，，6： | 2 |
| 12 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 13 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10 902显示文摘 | van der Hage JA van de Velde CJH Julien JP | 2001 | J Clin Oncol2001，19，22： | 1 |
| 14 | Minimizing total completion time in the two-machine flowshop by Lagrangian relaxation显示文摘 | Van de Velde S L | 1990 | Annals of Operations Research1990，26，： | 1 |
| 15 | An iterated dynasearch algorithm for the single-machine total weighted tardiness scheduling problem显示文摘 | Congram R K Potts C N van de Velde S | 2002 | Informs Journal on Computing2002，14，： | 1 |
| 16 | Intrathecal sufentanil and fetal heart rate abnormalities:a double-blind,double placebo-controlled trial comparing two forms of combined spinal epidural analgesia with epidural analgesia in labor显示文摘 | VAN DE VELDE M TEUNKENS A HANSSENS M | 2004 | Anesth Analg2004，98，4： | 1 |
| 17 | Status of extended lymph node dissection:Locoregional control is the only way to survive gastric cancer显示文摘 | Hartgrink HH van de Velde CJ | 2005 | J Surg Oncol2005，90，3： | 1 |
| 18 | Preoperative chemotherapy in primary operable breast cancer:results from the European organization for research and treatment of cancer trial 10902 显示文摘 | van der Hage JA van de Velde CJH Julien JP | 2001 | J Clin Oncol2001，19，22： | 1 |
| 19 | Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision inprimary rectal cancer:report of a multicenter randomized trial显示文摘 | Kapiteijn E Van de Velde | 2002 | J Clin Oncol2002，20，3： | 1 |
| 20 | Late side eftects ot short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch colorectal cancer group study 显示文摘 | Pceters KC van de Velde C J Leer JW | 2005 | J Clin Oncol2005，23，25： | 1 |
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