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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Characterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis显示文摘 | Wegkamp A van Oorschot W de Vos WM | 2007 | Applied Environmental Microbiology2007，73，8： | 1 |
| 3 | TheWnt/frizzled/GSK-3p pathway : a novel therapeutic target forcardiac hypertrophy 显示文摘 | Blankesteijn WM van de Schans VA ter Horst P | 2008 | Trends Pharmacol Sci2008，29，4： | 1 |
| 4 | Human xenografi mod- els as useful tools to assess the potential of novel therapeutics in prostate cancer显示文摘 | Van Weerden WM Bangma C De Wit R | 2009 | Bri J Cancer2009，100，1： | 1 |
| 5 | Characterization of the Lactococcus lactis Lactose operon promoter:Contribution of flanking sequences and LacR repressor to promoter activity显示文摘 | Van R J Gasson M J De WM | | 0，，： | 1 |
| 6 | The Wnt/frizzled/GSK-313 pathway: a novel therapeutic target for cardiac hypertrophy 显示文摘 | Blankesteijn WM van de Schans VA ter Horst P | 2008 | Trends Pharmacol Sci2008，29，4： | 1 |
| 7 | Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment显示文摘 | van de Pol LA van der Flier WM Korf ES | 2007 | Neurology2007，69，： | 1 |
| 8 | Clomiphene and hypospadias on a detailed level: signal or chance? 显示文摘 | Meijer WM de Jong-Van den Berg LT van den Berg MD | 2006 | Birth Defects Res A Clin Mol Teratol2006，76，4： | 1 |
| 9 | Impedance cardiography: can it replace thermodilution and the pulmonary artery catheter? 显示文摘 | Stout CL Van de Water JM Thompson WM | 2006 | Am Surg2006，72，8： | 1 |
| 10 | Low-molecular- weight heparin added to aspirin in the prevention of recurrent early- onset pre-eclampsia in women with inheritable thrombophilia:the FRUIT-RCT显示文摘 | de Vries JI van Pampus MG Hague WM | 2012 | J Thromb Haemost2012，10，1： | 1 |
| 11 | Radical prostatectomy can provide a cure for well-selected clinical stage T3 prostate cancer显示文摘 | Van Poppel H Goethuys H Callewaert P Vanuytsel L Van de Voorde WM BaertI | 2000 | Eur Urol2000，38，： | 1 |
| 12 | Angiotensin Ⅱ modulates frizzled- 2 receptor expression in rat vascular smooth muscle cens显示文摘 | Castoldi G Redaeni S van de Greef WM | 2005 | Clin Sci (Lond)2005，108，6： | 1 |
| 13 | Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial显示文摘 | Corine M Koopmans Denise Bijlenga Henk Groen Sylvia MC Vijgen Jan G Aarnoudse Dick J Bekedam Paul P van den Berg Karin de Boer Jan M Burggraaff Kitty WM Bloemenkamp Addy P Drogtrop Arie Franx Christianne JM de Groot Anjoke JM Huisjes Anneke Kwee Aren J va | 2009 | The Lancet2009，，9694： | 1 |
| 14 | Magnetic resonance imaging predictors of cognition in mild cognitive impairment显示文摘 | van de Pol LA Korf ESC van der Flier WM | 2007 | Arch Neurol2007，64，7： | 1 |
| 15 | ynthesis and degradation o~ phytochelatins in cadmium sensitive and cadmium-tol- erant Silene vu/gar/s 显示文摘 | DE KNECHT J A VAN BAREN N TEN BOOKUM WM | 1995 | Plant Sci1995，106，： | 1 |
| 16 | Low-molecular- weight heparin added to aspirin in the prevention of recurrent early- onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT 显示文摘 | de Vries JI van Pampus MG Hague WM | 2012 | J Thromb Haemost2012，10，1： | 1 |
| 17 | Value and limita- tions of measuring HER-2 extracellular domain in the serum of breast cancer patients 显示文摘 | Leary AF Hanna WM van de Vijver M J | 2009 | J Clin Oncol2009，27，10： | 1 |
| 18 | Validation of transrectal ultrasonographic volumetry for orthotopic prostate tumours in mice显示文摘 | Kraaij R Van Weerden WM De Ridder CM | 2002 | Lab Anim2002，36，2： | 1 |
| 19 | Magnetic resonance imaging predictors of cognition in mild cognitive impairment显示文摘 | van de Pol LA Korf ES van der Flier WM | 2007 | Arch Neurol2007，64，7： | 1 |
| 20 | The diagnostic value of sural nerve T cells in chronic inflammatory demyelina- ting polyneuropathy显示文摘 | Bosboom WM Van den Berg LH De BL | 1999 | Neurology1999，53，4： | 1 |
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