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| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | locally a-vailable heparin modulates inflammatory cell recruit-ment in a manner independent of anticoagulant activi-ty显示文摘 | LEVER R SM AILBEGO VIC A PAGE C P | 2010 | Eur J Pharmacol2010，630，： | 1 |
| 3 | Impact of the pulmonary arterycatheter in critically ill patients:meta-analysis of randomized clinicaltrials显示文摘 | Monica R Vic H Lynne W | 2005 | JAMA2005，294，13： | 1 |
| 4 | Dynamic phasors in modeling and analysis of unbalanced polyphase AC machines显示文摘 | Stanko vic A M Sanders S R | | 0，，01： | 1 |
| 5 | Isolation, biochemical characterisation, and culture of lung type Ⅱ cells of the rat 显示文摘 | Richards R J Davies N Atkins J Orefoo VIC | 1987 | Lung1987，165，3： | 1 |
| 6 | Risk of dia-betes associated with prescribed glucocorticoids in a large popula-tion显示文摘 | GULLIFORD M C CHARLTON J LATINO VIC R | 2006 | Diabetes Care2006，29，12： | 1 |
| 7 | CYFRA2I - 1 in non - small cell lung cancer - standardisation and appli - cation during diagnosis 显示文摘 | PAV1 ( - VIC R BUBANOVI6 G FRANJEVICA | 2008 | Coil Antropol2008，32，2： | 1 |
| 8 | Location, Accessibility and Regional Development: The Appraisal of Trans -European networks 显示文摘 | Vic Kerman R | 1996 | Transport Policy1996，2，4： | 1 |
| 9 | Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF)显示文摘 | Adrian F. Hernandez Christopher M. O’Connor Randall C. Starling Craig J. Reist Paul W. Armstrong Kenneth Dickstein Todd J. Lorenz W. Brian Gibler Vic Hasselblad Michel Komajda Barry Massie John J.V. McMurray Markku Nieminen Jean L. Rouleau Karl Swedberg R | 2009 | American Heart Journal2009，，2： | 1 |
| 10 | Micellar nanocontainers distribute to defined cytoplasmic organelles显示文摘 | vic R Luo L Eisenberg A MaysingSaer D | 2003 | Science2003，300，5619： | 1 |
| 11 | Properties of natural rubber/carboxilated styrene-butadiene latices blends 显示文摘 | Pop~)vic R Milenkovic D Pop')vie R | 2005 | Sci- entific-Technical Review2005，55，34： | 1 |
| 12 | 慢性疾病治疗方案中的干预措施——哪些是有效的?文献汇总分析显示文摘目的:系统评价已发表的疾病治疗方案中各种干预措施的特点和疗效相关证据。 设计:汇总分析。 数据来源:从计算机数据库中检索到的1987-2001年间发表的英文文献。 入选文献:评价118种疾病治疗方案的102篇文献。 | Scott R Weingarten James M Henning Enkhe Badamgarav Kevin Knight Vic Hasselblad Anacleto Gano Jr Joshua J Ofman 孙静 | 2004 | 英国医学杂志中文版2004，7，4： | 0 |
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