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| 1 | 双醛淀粉改性明胶膜的制备与性能研究显示文摘利用双醛淀粉(DAS)交联明胶,制备了DAS改性明胶膜,研究了DAS改性对明胶膜力学性能、溶胀性能、吸湿性能和热降解稳定性能的影响。结果表明:DAS能有效地与明胶发生交联反应。适量DAS的交联可大幅提高明胶膜的拉伸强度。DAS交联可赋予明胶稳定的结构,有效地降低明胶膜对水的敏感性。随着DAS用量的增加,明胶膜的平衡溶胀率逐渐降低。DAS交联可降低明胶膜的吸湿率,在DAS用量为3%~5%时,膜的平衡吸湿率最低。经DAS改性后,明胶膜的热降解温度升高,表明其耐热降解稳定性得到提高。 | 郑学晶 李俊伟 刘捷 张振飞 刘小凡 王晶 汤克勇 | 2011 | 中国皮革2011，40，23： | 15 |
| 2 | 双醛淀粉/胶原共混膜的制备及性能研究显示文摘以双醛淀粉(DAS)和胶原为原料,按照一定的比例将两者混合、干燥,制得双醛淀粉/胶原共混膜。本文考察了DAS对胶原膜性能的影响,研究了不同盐溶液对共混膜溶胀度的影响以及共混膜的盐敏性、pH敏感性、亲水性等。利用傅里叶红外光谱法(FTIR)和差示扫描量热法(DSC)对共混膜的化学结构进行研究,结果表明胶原与DAS之间发生了化学交联。交联作用提高了材料的稳定性,扩大了材料的应用范围。 | 程庆甦 王硕 李秋鸿 陈婧 刘华青 穆畅道 | 2010 | 皮革科学与工程2010，20，6： | 10 |
| 3 | Preparation of fluorescence starch-nanoparticle and its application as plant transgenic vehicle显示文摘Starch-nanoparticles were synthesized in water-in-oil microemusion at room temperature, and the starch-nanoparticles were coated with poly-L-lysine. The surface of the starch-nanoparticles was combined with fluorescence material Ru(bpy)32+·6H2O, and then the particles were characterized via transmission electron microscope. The fluorescence nanoparticles were conjugated with plasmid DNA to form complexes, and then treated with ultrasound and DNase I. pEGAD plasmid DNA-nanoparticle complexes were co-cultured with plant suspension cells of Dioscrea Zigiberensis G H Wright, and treated with ultrasound. The results show that the diameter of the fluorescence starch-nanoparticles is 50-100 nm. DNA-nanoparticle complexes can protect DNA from ultrasound damage as well as from DNase I cleavage. Mediated by ultrasound, pEGAD plasmid DNA-nanoparticle complexes can pierce into the cell wall, cell membrane and nucleus membrane of plant suspension cells. The green fluorescence protein(GFP) gene at a high frequency exceeds 5%. This nano-biomaterial can efficiently solve the problem that exterior genes cannot traverse the plant cell wall easily. | 刘俊 王凤华 王玲玲 肖苏尧 童春意 唐冬英 刘选眀 | 2008 | Journal of Central South University of Technology2008，15，6： | 6 |
| 4 | Dialdehyde starch nanoparticles as antitumor drug delivery system:An in vitro,in vivo,and immunohistological evaluation显示文摘Sustaining the release of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner is a potentially powerful technology. A new drug carrier-dialdehyde starch nanoparticle (DASNP) that can sustain the loading and release of 5-fluorouracil (5-Fu) antitumor drug is reported in this study. IR spectrophotometer and 1H NMR confirmed the formation of aldehyde groups, and scan electron microscope determinations showed that the dialdehyde starch nanoparticles obtained had an average diameter of 90 nm. 5-Fu, the model drug, was conjugated into nanoparticles by aldehyde groups. These 5-Fu-binding nanoparticles significantly enhanced breast cancer cell (MCF-7) inhibition in vitro compared with free 5-Fu. After subcutaneous 0 injection in the breast tumor-loaded rats, 5-Fu-DASNP exhibited remarkable tumor-inhibitory efficacy determined by measuring tumor weight in vivo. The tumor inhibition of 5-Fu-DASNP was 61%±6%, whereas that of free 5-Fu was only 42%±4%. Bcl-2/Bax immunohistochem-istry studies indicated that 5-Fu-DASNP remarkably induced tumor tissue necrosis. These results demonstrated that the DASNP prepared in this work is a potentially effective drug carrier. | XIAO SuYao LIU XuanMing TONG ChunYi ZHAO LiChao LIU XiaoJuan ZHOU AiMei CAO Yong | 2012 | Chinese Science Bulletin2012，57，24： | 3 |
| 5 | U0126纳米药物载体的制备及其用于肺动脉高压治疗显示文摘通过纳米载体增加抗收缩化合物U0126的生物利用度,以提高其抗肺动脉高压的效果。首先制备阳离子双亲淀粉包材,通过该材料构建U0126纳米药物载体,并检测其载药性能,利用体外肺动脉血管培养模型评价其在肺动脉高压治疗方面的效果。结果表明,所制备的阳离子双亲淀粉包材毒性低,可有效负载疏水性化合物U0126,载体为平均粒径(113±6.9)nm的球形胶束,包裹率达到(93.8±2.8)%,载药量为(17.4±4.6)%,在不同溶液环境中均具有良好的稳定性,且具有缓释效果。U0126纳米药物载体可有效积累于内皮细胞受损的血管壁内,而在正常血管壁中积累较少,较之游离U0126具有更好的干预效果。证明U0126纳米药物载体能显著提高药物对肺动脉高压的逆转效果。 | 李科 徐仓宝 张亚萍 张彦 | 2020 | 化工科技2020，28，4： | 1 |
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