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| 1 | Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury显示文摘Neurotrophic factors,currently administered orally or by intravenous drip or intramuscular injection,are the main method for the treatment of peripheral nerve crush injury.However,the low effective drug concentration arriving at the injury site results in unsatisfactory outcomes.Therefore,there is an urgent need for a treatment method that can increase the effective drug concentration in the injured area.In this study,we first fabricated a gelatin modified by methacrylic anhydride hydrogel and loaded it with vascular endothelial growth factor that allowed the controlled release of the neurotrophic factor.This modified gelatin exhibited good physical and chemical properties,biocompatibility and supported the adhesion and proliferation of RSC96 cells and human umbilical vein endothelial cells.When injected into the epineurium of crushed nerves,the composite hydrogel in the rat sciatic nerve crush injury model promoted nerve regeneration,functional recovery and vascularization.The results showed that the modified gelatin gave sustained delivery of vascular endothelial growth factors and accelerated the repair of crushed peripheral nerves. | Wanlin Xu Yifan Wu Hao Lu Yun Zhu Jinhai Ye Wenjun Yang | 2022 | Neural Regeneration Research2022，17，9： | 2 |
| 2 | 防御素作用糖尿病创面机制的研究进展显示文摘糖尿病创面是糖尿病患者最常见的严重并发症之一,也是糖尿病患者致残和致死的重要因素,临床上主要通过控制感染、伤口清创、外科手术等方式进行治疗,然而其疗效不尽如人意。因此需要探索新的途径,找到潜在的治疗策略,以达到更好的糖尿病创面治疗效果。目前已有的研究结果表明,防御素能够在抗菌、免疫调节、促进血管生成、促进组织再生和改善胰岛素抵抗等方面发挥重要作用。本综述总结了防御素在糖尿病创面中的现有研究进展,以期为糖尿病创面新的治疗方案提供前期研究基础。 | 谭植襄 王祥盛 童怡兰 杨希林 余墨声 朱占永 | 2021 | 中华实验外科杂志2021，38，12： | 1 |
| 3 | Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects显示文摘Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects,it has many clinical limitations.As an alternative,various tissue-engineered nerve grafts have been developed to substitute for autologous nerves.In this study,a novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in rats.The novel nerve graft greatly facilitated regeneration of the sciatic nerve and myelin sheath,reduced atrophy of the target muscle,and effectively restored neurological function.When the epineurium of the small autogenous nerve was removed,the degree of nerve regeneration was similar to that which occurs after autogenous nerve transplantation.These findings suggest that our novel nerve graft might eventually be a new option for the construction of tissue-engineered nerve scaffolds.The study was approved by the Research Ethics Committee of Peking University People's Hospital(approval No.2019 PHE27)on October 18,2019. | Bo Wang Chang-Feng Lu Zhong-Yang Liu Shuai Han Pi Wei Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang | 2022 | Neural Regeneration Research2022，17，5： | 0 |
| 4 | 聚己内酯多通道神经导管的制备及表征显示文摘神经导管(nerve guidance conduit,NGC)的通道数越多则越有利于神经再生,但受到技术和成本的限制,目前的多通道神经导管一般少于10个通道。为了制备通道数较多的NGC,采用边长10 cm的立方体铁架、直径0.15 mm的水溶性维纶纱线和直径3 mm的塑料空心管搭建一种牺牲模板,并结合冷冻干燥法制备直径为(2.70±0.30)mm、NGC长度大于2 cm、通道数约20个、内通道直径为(0.13±0.03)mm且通道之间存在孔结构的聚己内酯(polycaprolactone,PCL)多通道神经导管。对制备的多通道神经导管进行体外理化性能表征和体外细胞毒性检测表征,结果表明,制备的多通道神经导管能促进细胞的生长和增殖,具有较好的细胞相容性。 | 王菊粉 曾嘉梅 徐康丽 李金瑞 黄晨 柯勤飞 | 2022 | 东华大学学报(自然科学版)2022，48，1： | 0 |
| 5 | Role of defensins in diabetic wound healing显示文摘The adverse consequences resulting from diabetes are often presented as severe complications.Diabetic wounds are one of the most commonly occurring complications in diabetes,and the control and treatment of this is costly.Due to a series of pathophysiological mechanisms,diabetic wounds remain in the inflammatory phase for a prolonged period of time,and face difficulty in entering the proliferative phase,thus leading to chronic non-healing wounds.The current consensus on the treatment of diabetic wounds is through multidisciplinary comprehensive management,however,standard wound treatment methods are still limited and therefore,more effective methods are required.In recent years,defensins have been found to play diverse roles in a variety of diseases;however,the molecular mechanisms underlying these activities are still largely unknown.Defensins can be constitutively or inductively produced in the skin,therefore,their local distribution is affected by the microenvironment of these diabetic wounds.Current evidence suggests that defensins are involved in the diabetic wound pathogenesis,and can potentially promote the early completion of each stage,thus making research on defensins a promising area for developing novel treatments for diabetic wounds.In this review,we describe the complex function of human defensins in the development of diabetic wounds,and suggest potential therapeutic benefits. | Zhi-Xiang Tan Rui Tao Si-Cheng Li Bing-Zheng Shen Lan-Xia Meng Zhan-Yong Zhu | 2022 | World Journal of Diabetes2022，13，11： | 0 |
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