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| 1 | Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration显示文摘Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases.Here,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron microscopy.Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related proteins.We found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs.Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future. | Zhiyuan Zou Le Wang Zhifei Zhou Qing Sun Delong Liu Yan Chen Hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou | 2021 | Bioactive Materials2021，6，6： | 7 |
| 2 | Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration显示文摘Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but they can cause a series of complications. To address this problem,researchers have constructed various implantable biomaterials. However, the original pathological microenvironment of bone defects, such as residual tumors, severe infection, or other bone diseases, could further affect bone regeneration. Thus, the rational design of versatile biomaterials with integrated bone therapy and regeneration functions is in great demand. Many strategies have been applied to fabricate smart stimuli-responsive materials for bone therapy and regeneration, with stimuli related to external physical triggers or endogenous disease microenvironments or involving multiple integrated strategies. Typical external physical triggers include light irradiation, electric and magnetic fields, ultrasound, and mechanical stimuli. These stimuli can transform the internal atomic packing arrangements of materials and affect cell fate, thus enhancing bone tissue therapy and regeneration. In addition to the external stimuli-responsive strategy, some specific pathological microenvironments, such as excess reactive oxygen species and mild acidity in tumors, specific p H reduction and enzymes secreted by bacteria in severe infection, and electronegative potential in bone defect sites, could be used as biochemical triggers to activate bone disease therapy and bone regeneration.Herein, we summarize and discuss the rational construction of versatile biomaterials with bone therapeutic and regenerative functions. The specific mechanisms, clinical applications, and existing limitations of the newly designed biomaterials are also clarified. | Hongpu Wei Jinjie Cui Kaili Lin Jing Xie Xudong Wang | 2022 | Bone Research2022，10，1： | 3 |
| 3 | 电活性骨修复材料的研究现状与挑战显示文摘骨组织具有独特的电学特性,主要来自于相关细胞如骨细胞、成骨细胞和破骨细胞等与骨细胞外基质的相互作用,可视为介电性能、压电性能、热电性能、铁电性能和流动电位的组合[1]。骨组织的电学特性是调节其稳态、重塑和再生的关键因素。电活性生物材料是一类在外界刺激下能够产生电信号或在外界电刺激的作用下可以改变自身理化特性的生物材料。 | 张学慧 | 2022 | 口腔材料器械杂志2022，31，1： | 1 |
| 4 | 压电支架材料在骨组织工程的应用显示文摘生物电现象在骨发育、骨折愈合和成骨过程中起着至关重要的作用,具有生物电活性的压电材料有着与骨相似的压电效应。利用压电支架材料作为人工合成修复骨缺损材料,已成为当前的研究热点。本文综述了天然骨生物电现象、压电材料对成骨细胞的促增殖及促骨缺损修复作用,以及压电支架材料在骨组织工程领域的相关研究进展,总结并分析了未来压电支架材料在骨组织工程领域的研究方向。 | 姚喜军 商佳琪 黄秋瑾 胡子琪 任怡帆 邓久鹏 | 2022 | 生物医学工程研究2022，41，4： | 0 |
| 5 | 仿生电活性涂层钛植入材料促进骨结合的实验研究显示文摘目的评价仿生电活性钛酸钡(BaTiO3,BTO)/聚偏氟乙烯-三氟乙烯P(VDF-TrFE)涂层钛植入材料促进骨结合性能的效果。方法首先将直径为2 mm、长度为5 mm的医用纯钛圆柱进行表面喷砂-酸蚀处理,然后将BaTiO3/P(VDF-TrFE)溶液均匀涂覆在钛柱表面。待烘干后对涂层表面进行电晕极化处理。采用扫描电镜、能谱分析、原子力显微镜、水接触角测量仪分别对材料表面形貌、元素组成、表面粗糙度和亲疏水性进行表征检测,PLLA涂层钛柱作为对照材料。选取实验兔4只,在双侧胫骨位置各制备3个间隔为1 cm的圆形缺损,在左侧胫骨植入PLLA涂层钛柱,右侧胫骨植入仿生电活性涂层钛柱,术后4周和12周分别取材进行硬组织的骨形态检测分析。采用SPSS15.0软件对数据进行统计分析。结果理化性能表征检测显示,BaTiO3/P(VDF-TrFE)涂层和PLLA涂层均匀附着在钛柱表面,涂层厚度约50μm,且表面结构致密。电活性涂层可见钛酸钡纳米颗粒均匀分布在P(VDF-TrFE)基体内。两种涂层表面的粗糙度和水接触角无明显差异。电活性涂层具有稳定的压电性能,且压电常数接近生理量级。动物实验显示,术后4周,仿生电活性涂层材料表面和新骨结合紧密,涂层材料稳定无降解;而PLLA涂层材料表面由于材料有部分降解导致新骨结合较差,电活性涂层的骨结合率明显高于PLLA涂层。术后12周,两组的新骨成熟程度均增加,骨陷窝明显,仿生电活性涂层仍然保持稳定状态;而PLLA涂层进一步发生降解,和新骨结合程度弱于电活性涂层组。结论仿生电活性BaTiO3/P(VDF-TrFE)涂层钛可能作为一种具有促进骨整合功能的种植体涂层材料。 | 白云洋 孙晓雯 王逸君 张学慧 | 2021 | 骨科临床与研究杂志2021，6，1： | 0 |
| 6 | 低强度脉冲超声在口腔种植中的应用进展显示文摘口腔种植术是近年来新兴发展的一种用于修复牙列缺损、缺失的治疗技术。骨结合(ossfinintegration)即种植体表面与周围发育良好的骨组织在结构和功能上的紧密结合,是口腔种植的重要基础理论^([1])。随着种植技术的发展,现代口腔种植日渐高效化、广泛化。一方面,种植治疗的流程逐渐缩简,即刻早期修复成为临床种植修复的发展趋势^([2]);另一方面,种植治疗的适应证也逐步放宽,越来越多患有系统性基础疾病的患者得以受益^([3])。 | 叶鑫健 白怡婧 夏思齐 朱宇驰 汪淑华 | 2021 | 浙江临床医学2021，23，7： | 0 |
| 7 | 超声在骨组织工程中的应用进展显示文摘供体来源不足和术后并发症限制了骨移植在修复严重骨缺损中的广泛应用。因此,骨组织工程支架作为移植骨的潜在替代品被广泛研究。近年来,除了将各种细胞和生物活性分子引入骨组织工程支架外,诸多研究表明外源性物理刺激(超声波、光或热和电或磁场等)对骨组织再生也具有一定的促进作用。超声波是一种机械振动波,其在组织中传播时可以对细胞产生良好的机械效应。此外,超声波组织穿透能力强且安全性高,可以对组织深处的细胞和材料进行无创性干预。该文就超声在骨组织工程中的应用进行综述。 | 王洋 肖龙飞 耿弼江 沈龙祥 | 2024 | 国际骨科学杂志2024，45，1： | 0 |
| 8 | Magnetic field regulation of mouse bone marrow mesenchymal stem cell behaviours on TiO2 nanotubes via surface potential mediated by Terfenol‐D/P(VDF‐TrFE) film显示文摘It is challenging to match the mutual interactions between implant and host because the biomaterials usually cannot actively adjust their performance to the changing microenvironment.Surface potential is one of the critical factors affecting the bioactivity of biomaterials,but it is difficult to be directly controlled in vivo.Magnetic stimulation has attracted much attention due to its deep penetrability,good reliability,and convenient operability.Here,titanium dioxide(TiO_(2))nanotubes and Terfenol‐D/P(VDF‐TrFE)composite film are prepared by anodic oxidation and solution casting methods on opposite sides of a titanium sheet,respectively.Terfenol‐D magnetostrictive microparticles deform under a magnetic field,generating surface potential on the P(VDF‐TrFE)piezoelectric matrix through magneto‐electric coupling.Correspondingly,equal opposite charges are induced on the surface of TiO_(2) nanotubes.Stem cells cultured on TiO_(2) nanotubes show that cell adhesion,proliferation,and differentiation abilities can be regulated by magnetic strength,which correlates with the absorption of charged proteins.Therefore,a cascade coupling of magnetic,mechanical,electric,biochemical,and cellular effects is established.This work demonstrates the feasibility of regulating the bioactivity of biomaterials in vivo through a magnetic field. | Haisheng Qi Qi Ke Qiwen Tang Lei Yin Lixin Yang Chengyun Ning Jianyu Su Liming Fang | 2022 | Biosurface and Biotribology2022，8，3： | 0 |
| 9 | 压电生物材料在组织再生领域的研究与应用进展显示文摘人体的内源性电场调节着相关生理过程。电刺激已被证明能够促进组织修复和再生。压电生物材料作为一种能将机械能转化为电刺激的智能材料,在组织再生领域有着良好的应用前景。该文综述了目前压电生物材料的分类和其促进组织再生的作用机理,以及压电生物材料在骨组织、神经组织、皮肤组织、肌肉组织和心血管等组织再生领域的最新研究与应用进展,最后总结分析了目前压电生物材料在实际应用中存在的不足和相应的改进措施。 | 徐海鹏 王丽雲 赵斌 赵灿灿 林开利 | 2023 | 生物医学工程学进展2023，44，2： | 0 |
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