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| 1 | C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death显示文摘Lysosomes are degradation and signaling centers within the cell,and their dysfunction impairs a wide variety of cellular processes.To understand the cellular effect of lysosome damage,we screened natural smallmolecule compounds that induce iysosomal abnormality using Caenorhabditis elegans (C.elegans)as a model system.A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D)were identified that caused lysosome enlargement in C.elegans macrophage-like cells.Intriguingly,these compounds triggered cell death in the germ line independently of the canonical apoptosis pathway.In mammalian cells, ervachinines A-D induced lysosomal enlargement and damage,leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death.Further analysis revealed that this ervachinine-induced lysosome damage and lysosomal cell death depended on STAT3 signaling,but not RIP1 or RIP3 signaling.These findings suggest that lysosomedamaging compounds are promising reagents for dissecting signaling mechanisms underlying lysosome homeostasis and lysosome-related human disorders. | Yang Li Yu Zhang Qiwen Gan Meng Xu Xiao Ding Guihua Tang Jingjing Liang Kai Liu Xuezhao Liu Xin Wang Lingli Guo Zhiyang Gao Xiaojiang Hao Chonglin Yang | 2018 | Protein & Cell2018，9，12： | 2 |
| 2 | Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans显示文摘Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental disorder.It is largely unknown if defective arginine catabolism has any effects on mitochondria.Here we report that normal arginine catabolism is essential for mitochondrial homeostasis in Caenorhabditis elegans.Mutations of the arginase gene argn-1 lead to abnormal mitochondrial enlargement and reduced adenosine triphosphate(ATP)production in C elegans hypodermal cells.ARGN-1 localizes to mitochondria and its loss causes arginine accumulation,which disrupts mitochondrial dynamics.Heterologous expression of human ARGl or ARG2 rescued the mitochondrial defects of argn-1 mutants.Importantly,genetic inactivation of the mitochondrial basic amino acid transporter SLC-25A29 or the mitochondrial glutamate transporter SLC-25A18.1 fully suppressed the mitochondrial defects caused by argn-1 mutations.These findings suggest that mitochondrial damage probably contributes to the pathogenesis of hyperargininemia and provide clues for developing therapeutic treatments for hyperargininemia. | Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan Zhao Qiwen Gan Liyuan Zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang | 2020 | Journal of Genetics and Genomics2020，47，3： | 2 |
| 3 | Review of the Tuned Mass Damper Inerter(TMDI)in Energy Harvesting and Vibration Control:Designs,Analysis and Applications显示文摘Tuned mass damper inerter(TMDI)is a device that couples traditional tuned mass dampers(TMD)with an inertial device.The inertial device produces resistance proportional to the relative acceleration at its two ends through its“inertial”constant.Due to its unique mechanical properties,TMDI has received widespread attention and application in the past twenty years.As different configurations are required in different practical situations,TMDI is still active in the research on vibration control and energy harvesting in structures.This paper provides a comprehensive review of the research status of TMDI.This work first examines the generation and important vibration control characteristics of TMDI.Then,the energy harvesting performance of electromagnetic tuned mass damper inerter(EM-TMDI)is discussed.This work emphasizes the formation of a passive dynamic vibration absorber by coupling traditional TMD with inertial devices.This paper also summarizes the design and implementation of optimal vibration control and energy harvesting for TMDI.Furthermore,this paper details the applications of TMDI in the fields of bridges and building engineering.Finally,this paper summarizes the necessity of research on tuned mass-damper-inertia,the challenges faced currently,and future research directions,such as control of parameters in electromagnetic energy harvesting TMDI systems and low-cost TMDI. | Xiaofang Kang Qiwen Huang Zongqin Wu Jianjun Tang Xueqin Jiang Shancheng Lei | 2024 | Computer Modeling in Engineering & Sciences2024，139，6： | 0 |
| 4 | Response Time of Reactive Power Based on Different Definitions and Algorithms显示文摘Dynamic reactive power compensation equipment typically requires a fast response to output the necessary reactive power.The term'dynamic response time of reactive power'is often used but has never been clearly defined.This paper summarizes the reactive power calculations under different definitions and algorithms and considers these calculations in terms of signal processing to simulate and analyze the step response.This paper subsequently focuses on the widely used instantaneous reactive power algorithm and finally concludes that the dynamic reactive power response time closely depends on the reactive power calculation method itself.The single-phase instantaneous reactive power algorithm has the fastest response time.The reactive power response time of dynamic reactive devices in power systems is a minimum of a quarter of one cycle time for the well-known and widely used single-phase reactive power algorithms. | Taixun Fang Qiwen Zhou Fengfeng Ding Xiaodan Wu Zhao Li Houjun Tang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 0 |
| 5 | A pair of transporters controls mitochondrial Zn^(2+) levels to maintain mitochondrial homeostasis显示文摘Zn^(2+)is required for the activity of many mitochondrial proteins,which regulate mitochondrial dynamics,apoptosis and mitophagy.However,it is not understood how the proper mitochondrial Zn^(2+)level is achieved to maintain mitochondrial homeostasis.Using Caenorhabditis elegans,we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn^(2+).We demonstrate that SLC-30A9/ZnT9 is a mitochondrial Zn^(2+)exporter.Loss of SLC-30A9 leads to mitochondrial Zn^(2+)accumulation,which damages mitochondria,impairs animal development and shortens the life span.We further identify SLC-25A25/SCaMC-2 as an important regulator of mitochondrial Zn^(2+)import.Loss of SLC-25A25 suppresses the abnormal mitochondrial Zn^(2+)accumulation and defective mitochondrial structure and functions caused by loss of SLC-30A9.Moreover,we reveal that the endoplasmic reticulum contains the Zn^(2+)pool from which mitochondrial Zn^(2+)is imported.These findings establish the molecular basis for controlling the correct mitochondrial levels for normal mitochondrial structure and functions. | Tengfei Ma Liyuan Zhao Jie Zhang Ruofeng Tang Xin Wang Nan Liu Qian Zhang Fengyang Wang Meijiao Li Qian Shan Yang Yang Qiuyuan Yin Limei Yang Qiwen Gan Chonglin Yang | 2022 | Protein & Cell2022，13，3： | 0 |
| 6 | Magnetic field regulation of mouse bone marrow mesenchymal stem cell behaviours on TiO2 nanotubes via surface potential mediated by Terfenol‐D/P(VDF‐TrFE) film显示文摘It is challenging to match the mutual interactions between implant and host because the biomaterials usually cannot actively adjust their performance to the changing microenvironment.Surface potential is one of the critical factors affecting the bioactivity of biomaterials,but it is difficult to be directly controlled in vivo.Magnetic stimulation has attracted much attention due to its deep penetrability,good reliability,and convenient operability.Here,titanium dioxide(TiO_(2))nanotubes and Terfenol‐D/P(VDF‐TrFE)composite film are prepared by anodic oxidation and solution casting methods on opposite sides of a titanium sheet,respectively.Terfenol‐D magnetostrictive microparticles deform under a magnetic field,generating surface potential on the P(VDF‐TrFE)piezoelectric matrix through magneto‐electric coupling.Correspondingly,equal opposite charges are induced on the surface of TiO_(2) nanotubes.Stem cells cultured on TiO_(2) nanotubes show that cell adhesion,proliferation,and differentiation abilities can be regulated by magnetic strength,which correlates with the absorption of charged proteins.Therefore,a cascade coupling of magnetic,mechanical,electric,biochemical,and cellular effects is established.This work demonstrates the feasibility of regulating the bioactivity of biomaterials in vivo through a magnetic field. | Haisheng Qi Qi Ke Qiwen Tang Lei Yin Lixin Yang Chengyun Ning Jianyu Su Liming Fang | 2022 | Biosurface and Biotribology2022，8，3： | 0 |
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