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| 1 | HBV cccDNA in patients' sera as an indicator for HBV reactivation and an early signal of liver damage显示文摘AIM: To evaluate the covalently closed circle DNA (cccDNA)level of hepatitis B virus (HBV) in patients' liver and sera. METHODS: HBV DNA was isolated from patients' liver biopsies and sera. A sensitive real-time PCR method, which is capable of differentiation of HBV viral genomic DNA and cccDNA, was used to quantify the total HBV cccDNA. The total HBV viral DNA was quantitated by real-time PCR using a HBV diagnostic kit (PG Biotech, LTD, Shenzhen, China)described previously. RESULTS: For the first time, we measured the level of HBV DNA and cccDNA isolated from ten HBV patients' liver biopsies and sera. In the liver biopsies, cccDNA was detected from all the biopsy samples. The copy number of cccDNA ranged from from 0.03 to 173.1 per ceil, the copy number of total HBV DNA ranged from 0.08 to 3 717 per cell. The ratio of total HBV DNA to cccDNA ranged from 1 to 3 406. In the sera,cccDNA was only detected from six samples whereas HBV viral DNA was detected from all ten samples. The ratio of cccDNA to total HBV DNA ranged from 0 to 1.77%. To further investigate the reason why cccDNA could only be detected in some patients' sera, we performed longitudinal studies. The cccDNA was detected from the patients' sera with HBV reactivation but not from the patients' sera without HBV reactivation. The level of cccDNA in the sera was correlated with ALT and viral load in the HBV reactivation patients. CONCLUSION: HBV cccDNA is actively transcribed and replicated in some patients' hepatocytes, which is reflected by a high ratio of HBV total DNA vs cccDNA. Detection of cccDNA in the liver biopsy will provide an end-point for the anti-HBV therapy. The occurrence of cccDNA in the sera is an early signal of liver damage, which may be another important clinical parameter. | Johnny Sze | 2004 | World Journal of Gastroenterology2004，10，1： | 107 |
| 2 | 中医体质和宿主基因与HBV慢性感染的关系显示文摘随着以功能基因组学和蛋白质组学为核心的后基因组时代的到来,人们越来越关注个体体质与疾病的关系. | 庄泓 江家骥 | 2003 | 中西医结合肝病杂志2003，13，5： | 24 |
| 3 | Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population显示文摘AIM: To clarify whether -238G/A polymorphism of tumor necrosis factor-a (TNF-a) gene promoter region was associated with outcomes of hepatitis B virus (HBV) infection in Han population of northern China, and to analyze the geneenvironment interaction between -238G/A polymorphism and cigarette smoking or alcohol consumption. METHODS: A case-control study was conducted to analyze the association of TNF-a gene promoter polymorphism with HBV infection outcomes. A total of 207 patients with chronic hepatitis B (HB) and 148 cases of self-limited HBV infection from Ditan Hospital and Shunyi District Hospital in Beijing, respectively were recruited. History of smoking and alcohol drinking was inquired by a questionnaire. The -238G/A polymorphism of TNF-a gene promoter was genotyped by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). RESULTS: The frequencies of GG and GA genotypes were 98.07% and 1.93% in chronic HB patients and 93.24% and 6.76% in self-limited HBV infection individuals, respectively (X^2=5.30, P=-0.02). The frequency of G allele was significantly higher in patients with chronic HB that in individuals with self-limited HBV infection (99.03% vs 96.62%, X^2=5.20, P=0.02). Only modestly increased risk of onset of chronic HB was found in smokers (OR=1.40, 95% CI: 0.87-2.28, P=0.14) and drinkers (OR=-1.26, 95%CI: 0.78-2.05, P=-0.32). There was a positive interaction between genotype GG and cigarette smoking with an interaction index (Ⅱ) of 2.95, or alcohol consumption with an Ⅱ of 1.64. CONCLUSION: The -238G/A polymorphism of TNF-a gene promoter region is independently associated with different outcomes of HBV infection. | Liang-PingLu Xing-WangLi YingLiu Guo-ChangSun Xue-PingWang Xi-LinZhu Quan-YouHu HuiLi | 2004 | World Journal of Gastroenterology2004，10，12： | 19 |
| 4 | HLA-DQA1基因多态性与HBV感染结局相关显示文摘目的探讨中国汉族人群人类白细胞抗原(HLA)-DQA1基因多态性是否与乙型肝炎病毒(HBV)感染结局相关联。方法以213例HBV自限性感染者和420例慢性乙肝患者为研究对象,应用聚合酶链反应-序列特异性引物(PCR-SSP)技术进行HLA-DQA1基因分型,用EPI和SPSS软件分析DQA1多态性的分布频率及其组间差异。结果DQA1*0102在慢性乙肝组的分布频率显著低于HBV自限性感染组(15.47%比较20.42%,P<0.05),而DQA1*0201在慢性乙肝组的分布频率显著高于HBV自限性感染组(10.48%比较6.10%,P<0.05)。调整性别、年龄等混杂因素影响的非条件logistic回归分析结果显示,与HLA-DQA1其他等位基因相比,携带DQA1*0102者降低慢性乙肝发生的风险(P<0.05,OR=0.69,95%C I:0.49-0.96),而携带DQA1*0201者增加慢性乙肝发生的风险(P<0.05,OR=1.77,95%C I:1.09-2.87)。结论HLA-DQA1基因多态性可能是影响HBV感染结局的重要宿主遗传因素。 | 陈冬梅 高冀荣 都特 郭新会 李卓 刘英 李辉 | 2006 | 基础医学与临床2006，26，5： | 18 |
| 5 | 干扰素γ基因内含子1+874位点多态性与乙型肝炎病毒感染关系的研究显示文摘目的研究干扰素γ(IFN-γ)基因内含子1+874位点多态性与乙型肝炎病毒(HBV)感染、转归的关系,探讨慢性HBV感染的遗传易感因素。方法采用序列特异性引物-聚合酶链反应(PCR-SSP)技术检测231例慢性HBV携带患者、165例自限性HBV感染者和135名正常对照者IFN-γ基因内含子1+874位点T/A单核苷酸多态性。结果慢性HBV感染组IFN-γ基因+874位点AA基因型频率(TT、TA、AA频率分别为9.1%、12.1%、78.8%)高于正常对照组(TT、TA、AA频率分别为12.6%、23.0%、64.4%)(χ2=9.60,P=0.008);而自限性HBV感染组(TT、TA、AA频率分别为13.9%、23.7%、62.4%)和对照组之间差异无显著性(χ2=0.16,P=0.92)。结论IFN-γ基因内含子1+874位点多态性与慢性HBV感染有关,该位点多态性可能在决定个体HBV感染遗传易感性方面有一定意义。 | 张平安 吴健民 李艳 | 2006 | 中华流行病学杂志2006，27，1： | 13 |
| 6 | Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B显示文摘AIM:To investigate the relationships between polymorphisms of interleukin-lB (IL-1B) promoter region -511CLT and interleukin-1 receptor antagonist gene (IL-1RN) and susceptibility to chronic hepatitis B in Chinese population. METHODS: Genomic DNA was extracted from the peripheral blood of 190 patients with chronic hepatitis B and 249 normal controls and then subjected to polymerase chain reaction (PCR) amplification. The PCR products were digested by restriction endonuclease AvaI. The products of digestion were subjected to 20 g/L gel electrophoresis and ethidium bromide staining. RESULTS: The frequencies of IL-1B (-511) genotypes CC, CT and TT in patients with chronic hepatitis B were 23.7%, 49.5% and 26.8%, while 26.1%, 47.4% and 26.5% respectively in controls. The results showed that there was no significant difference in the frequencies of alleles or genotypes in IL-1B between patients with chronic hepatitis B and controls. The distributions of IL-1B (-511) genotype CC were significantly different between the two subgroups (HBV-DNA ≤1×10^3 copies/mL as subgroup I, HBV-DNA> 1×10^3 copies/mL as subgroup Ⅱ) of chronic hepatitis B (P=0.029). Only four of the five kinds of polymorphism (1/1, 1/2, 2/2 and 1/4) were found in this study. The frequencies of IL-1RN genotypes 1/1, 1/2, 2/2 and 1/4 were 88.9%, 9.0%, 0.5% and 1.6% in patients with chronic hepatitis B respectively, while were 81.1%, 16.9%, 0.4% and 1.6% respectively in controls. The frequencies of genotype1/2 and IL-1RN allele 2 in patients with chronic hepatitis B were lower than those in controls (P=0.016 and P=0.029, respectively). CONCLUSION: There is an association between polyrnorphisms of the promoter region -511C/T of IL-1B and IL-1RN intron 2 and chronic hepatitis B virus infection. SubJects with IL-1RN 2 may be resistant to HBV infection, and IL-1B(-511) geNotype CC is closely related with HBV-DNA replication, which gives some new clues to the study of pathogenesis of chronic hepatitis B. | Ping-AnZhang YanLi PuXu Jian-MinWu | 2004 | World Journal of Gastroenterology2004，10，12： | 13 |
| 7 | 汉族人白细胞介素-18基因启动子多态性与慢性乙型肝炎的相关性研究显示文摘目的探讨中国汉族人白细胞介素-18(interleukin-18,IL-18)基因启动子单核苷酸多态性及其与慢性乙型肝炎易感性之间的关系。方法应用序列特异性引物-聚合酶链反应技术,检测231例慢性乙型肝炎患者和300名正常人IL-18基因启动子-607C/A、-137G/C单核苷酸多态性位点基因型。结果正常对照组和慢性乙型肝炎组中,IL-18基因启动子-607C/A位点3种基因型频率分别为CC型:0.22(66/300)和0.27(62/231),CA型:0.53(160/300)和0.50(116/231),AA型:0.25(74/300)和0.23(53/231);IL-18基因启动子-137G/C位点3种基因型频率分别为GG型:0.67(202/300)和0.79(182/231),GC型:0.30(90/300)和0.19(45/231),CC型:0.03(8/300)和0.02(4/231)。经χ2检验,慢性乙型肝炎组IL-18基因启动子-137GG分布频率显著高于正常对照组(χ2=8.55,P=0.003),而-607C/-137C和-607A/-137C单倍型频率显著低于正常对照组。进一步比较慢性乙型肝炎患者IL-18基因启动子多态性与乙型肝炎病毒(hepatitisB virus,HBV)DNA复制的关系,发现高水平HBV-DNA组-607位点AA基因型分布频率明显低于低水平HBV-DNA组(χ2=6.03,P=0.014)。结论汉族人慢性乙型肝炎与IL-18基因启动子-607C/A、-137G/C单核苷酸多态性相关,其中IL-18基因启动子-137位点C等位基因可能对机体HBV感染有保护作用,而启动子-607位点AA型对感染后HBV-DNA的复制可能有抑制作用。 | 张平安 吴健民 李艳 杨相升 | 2005 | 中华医学遗传学杂志2005，22，5： | 12 |
| 8 | 白细胞介素10基因启动子区多态性与乙型肝炎病毒感染预后的关联研究显示文摘目的探讨中国汉族人白细胞介素10基因(interleukin10gene,IL10)启动子区单核苷酸多态性与乙型肝炎病毒(hepatitisBvirus,HBV)感染、转归的关联。方法采用聚合酶链反应-限制性片段长度多态性分析方法,检测231例HBV感染者,165例HBV感染康复者和135名正常对照者IL10基因启动子-1082G/A、-819T/C、-592A/C位点基因型。结果IL10基因启动子-1082G/A、-819T/C、-592A/C位点基因型和等位基因在HBV感染组、HBV感染康复组和正常对照组之间的分布频率比较差异无统计学意义(P>0.05),在血清HBV-DNA<1×103拷贝/mL的HBV感染者组和HBV-DNA≥1×103拷贝/mL组之间的分布频率比较差异亦无统计学意义(P>0.05);但IL10基因启动子-819T/C和-592A/C位点基因型和等位基因在HBV无症状携带组和慢性乙型肝炎组之间的分布差异有统计学意义(P<0.05),-819T/C位点TT型和-592A/C位点AA型在慢性乙型肝炎组的频率明显较高。结论汉族人IL10基因启动子多态性可能与人群对HBV易感性及感染后的病毒血症水平无显著相关性;但IL10启动子-819T/C和-592A/C位点基因多态性与HBV感染后的肝脏炎症反应有关。 | 张平安 李艳 杨相升 | 2006 | 中华医学遗传学杂志2006，23，4： | 12 |
| 9 | HLA-DRB1及HLA-DQA1单倍型与乙型肝炎病毒感染结局的关联研究显示文摘目的探讨中国北方汉族人群HLA-DRB1、DQA1单倍型与乙型肝炎病毒(hepatitisBvirus,HBV)感染不同结局的关系。方法采用序列特异性引物聚合酶链反应(sequencespecificprimerspolymerasechainreaction,PCR-SSP)技术检测HLA-DRB1、DQA1等位基因,并比较207例慢性乙型肝炎患者,212名无症状HBV慢性携带者(HBV携带者),148例自限性HBV感染者的单倍型频率。结果自限性HBV感染组单倍型DRB1*04-DQA1*0301的频率为10.03%,显著高于慢性乙肝组的3.66%(P=0.0005);DRB1*15/*16-DQA1*0102的频率为6.80%,显著高于慢性乙肝组的1.94%(P=0.0012)和无症状HBV慢性携带者组的1.65%(P=0.004);DRB1*04-DQA1*0302单倍型在慢性乙型肝炎组的频率为3.10%,明显高于自限性HBV感染组的0.39%(P=0.0077)。结论HLA-DRB1、DQA1单倍型与个体感染HBV后的不同结局存在显著关联。 | 卢亮平 李兴旺 刘英 孙国常 陈志海 朱席琳 胡全有 李辉 | 2006 | 中华医学遗传学杂志2006，23，4： | 12 |
| 10 | 新生儿HBe Ag在HBV宫内感染中的作用显示文摘目的:探讨新生儿HBeAg在HBV宫内感染中的作用.方法:收集HBsAg阳性住院待产孕妇,采ELISA方法和abbott试剂对产妇和新生儿HBeAg、HBsAg进行检测结果:57例孕妇血清经实验室复查,HBsAg均阳性,其中HBeAg阳性孕妇15例.15例HBeAg阳性孕妇所产的16例新生儿有11例HBeAg阳性(68.75%).新生儿HBsAg阳性3例,全部产自于HBeAg阳性母亲,且其外周血HBeAg均阳性.统计分析显示新生儿HBeAg是HBV宫内感染的危险因素(P<0.05).结论:新生儿HBeAg在HBV官内感染过程中起重要作用. | 邵中军 门可 徐剑秋 徐德忠 闫永平 张景霞 | 2004 | 世界华人消化杂志2004，12，2： | 11 |
| 11 | Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection显示文摘Hepatitis B virus(HBV)infection is still a public health problem worldwide,being endemic in some parts of the world.It can lead to serious liver diseases such as chronic hepatitis,cirrhosis,and hepatocellular cancer.The differences in host immune response can be one of the reasons for the various clinical presentations of HBV infection.Polymorphisms of genes encoding the proinflammatory and antiinflammatory cytokines,which are responsible for regulation of the immune response,can affect the clinical presentation of the infection.Particularly,the polymorphisms of the genes encoding cytokines such as interleukin(IL)-1,IL-6,IL-8,IL-10,IL-18,IL-28B,interferon-γ,tumor necrosis factor-α,tumor growth factor-β1,and regulatory molecules like vitamin D receptor and chemokine receptor 5 can be responsible for different clinical presentations of HBV infections.The genomic information about cytokines and other mediators can be important for determining high-risk people for developing chronic hepatitis or hepatocellular cancer and may be used to plan treatment and preventive approaches for these people.In this review,the current knowledge in the literature on the association between cytokine/regulatory molecule gene polymorphisms and clinical course of chronic HBV infec-tion is summarized,and the clinical implementations and future prospects regarding this knowledge are discussed. | Semra Tun?bilek | 2014 | World Journal of Gastroenterology2014，20，20： | 11 |
| 12 | 单核苷酸多态性、环境因素与肝细胞肝癌遗传易感性的关系显示文摘肝细胞肝癌(HCC)的发生和演进是一个多基因、多因素的复杂过程,是遗传与环境因素相互作用的结果。单核苷酸多态性(SNP)作为第三代遗传标记,充分反映了个体间的遗传差异,决定了个体对疾病的易感性,正成为肝癌遗传易感性研究的重要工具。 | 纪龙 余红平 | 2009 | 卫生研究2009，38，2： | 9 |
| 13 | IL-6基因多态性与乙型肝炎慢性化的相关性显示文摘目的探讨汉族成人IL-6基因多态现象与乙型肝炎慢性化的关系。方法收集118例慢性乙型肝炎(CHB)患者和61例急性乙型肝炎(AHB)患者外周血,提取基因组DNA;采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)分析方法进行IL-6-572C/G和-597G/A基因分型。结果 CHB组IL-6-572G等位基因频率显著高于AHB组(χ2=8.627,P=0.003)。与CC基因型相比,CG和GG基因型携带者发生慢性化的危险性升高(ORCG=2.024,95%CI:1.009~4.065;ORGG=3.367,95%CI:1.169~9.709)。结论 IL-6-572基因位点多态性与乙型肝炎慢性化有关,携带-572GG基因型的乙型肝炎患者易发生慢性化。 | 高宝霞 浦江 张国顺 高华 冯福民 | 2012 | 肝脏2012，17，10： | 8 |
| 14 | 乙型肝炎病毒基因型在无症状感染者、慢性乙肝和肝硬化患者中分布研究显示文摘目的探讨乙型肝炎病毒基因型与HBV感染结局之间存在关联。方法采用病例-对照研究方法,征集300例无症状感染者、668例慢性乙肝患者和108例肝硬化患者作为研究对象,应用聚合酶链反应(PCR)方法对乙型肝炎病毒基因型进行测定。结果在无症状携带组、慢性肝炎组和肝硬化组中,HBVDNA阳性率分别为42·7%、91·0%和50·0%。无症状携带组HBV基因分布分别为B型28·1%、C型68·8%和混合型3·1%。慢性乙型肝炎为B型20·9%、C型72·0%和BC混合型7·1%。肝硬化组为B型11·1%、C型83·3%和混合型5·6%。不同组别的HBV病毒基因型构成比不同(χ2=9·981,P=0·041)。结论HBV病毒基因型可能是影响HBV感染结局的重要因素。 | 李洪权 李卓 张作文 李俊红 刘英 高冀荣 勾春艳 郭新惠 李辉 | 2005 | 中国预防医学杂志2005，6，3： | 8 |
| 15 | 干扰素-γ基因多态性与干扰素治疗慢性乙肝患者持久应答的关系显示文摘目的探讨干扰素-γ(IFN-γ)启动子基因874位点的单核苷酸多态性(SNP)与IFNα-2b治疗慢性乙肝(CHB)持久应答的关系。方法选择CHB患者106例,应用PCR-SSP技术分析宿主的IFN-γ启动子基因874位点的SNP,患者给予IFNα-2b治疗1年,随访1年,比较SNP与IFNα-2b疗程结束时完全应答、停药后随访1年完全应答(持久应答)的关系。结果在标准疗程结束时,完全应答的患者中三种基因型的分布无统计学差异(χ2=3.594 9,P=0.165 7)。而在持久应答患者中三种基因型的分布有统计学差异,TT基因型患者的持久应答率高于其他两种基因型患者(χ2=6.639 8,P=0.036 1)。结论 CHB患者对IFNα-2b治疗的持久应答与IFN-γ基因型有一定关联性,尤其与TT基因型关联更大。 | 潘永平 樊晓慧 邱梦标 粟庆娟 毛红霞 熊水印 龚辉 | 2012 | 山东医药2012，52，33： | 7 |
| 16 | 中国北方汉族人群HBV携带者和慢性乙肝患者TNF-α基因启动子区单核苷酸多态性分析显示文摘目的探讨在中国北方汉族人群中TNF-α基因启动子区单核苷酸多态性(SNPs)及其单倍型是否与HBV感染结局相关联。方法以212例无症状HBV携带者和207例慢性乙肝患者为研究对象,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)和序列特异性引物-PCR(SSP-PCR)方法对TNF-α基因启动子区5个位点,进行基因分型,用EPI和EH等软件分析各位点等位基因、基因型、单倍型频率及其组间差异。结果TNF-α基因-238GG基因型和-863CC基因型是HBV感染后个体发生乙型肝炎慢性化的易感因素(P=0.05,P<0.01)。5个位点组成的单倍型GGCCT在慢性肝炎组的频率显著低于无症状携带组(P<0.05),单倍型GGCAT和GGTAT在慢性肝炎组的频率显著高于无症状携带组(P<0.05)。结论TNF-α基因启动子区多态性可能是影响HBV感染结局的重要宿主遗传因素之一。 | 刘英 李俊红 都特 朱席琳 卢亮平 李卓 李辉 | 2005 | 基础医学与临床2005，25，12： | 7 |
| 17 | Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection显示文摘Objectives To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-α) gene promoter were associated with outcomes of hepatitis B virus infection. Methods A total of 246 HBV self-limited infected subjects and 443 chronic hepatitis B (HB) patients were recruited in this case-control study. TNF-α-238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequency of TNF-α-238 GG (90.7%) in chronic HB group was significantly lower than that (95.1%) in self-limited group (P=0.041). The frequency of TNF-α-857 CC (79.7%) in chronic HB patients was significantly higher than that (70.9%) in self-limited infected subjects (P=0.021). Multiple logistic regression analysis revealed that both TNF-α-238GA and -857CC were independently associated with chronic HB. Conclusions TNF-α promoter variants are likely to play a substantial role in influencing the outcomes of HBV infection. | HONG-QUAN LI ZHUO LI YING LIU JUN-HONG LI JIAN-QUN DONG JI-RONG GAO CHUN-YAN GOU AND HUI LI | 2006 | Biomedical and Environmental Sciences2006，19，2： | 7 |
| 18 | HBV感染者人类白细胞Ⅰ,Ⅱ类抗原等位基因多态性分析显示文摘目的:分析HBV感染者体内病毒持续和清除与HLA-A,B,DRB1各位点等位基因分布频率的关系.方法:采用序列特异性引物-聚合酶链式反应(PCR-SSP)技术,对61例慢性乙型肝炎患者(CHB)、32例HBV感染后病毒清除者(感染恢复组)和40例骨髓移植供者(正常组)的外周血白细胞,进行人类白细胞抗原等位基因(HLA-A,B,DRB1)分型检测.结果:在慢性乙型肝炎组,HLA-DRB1*12等位基因分布频率较正常组(0.230vs0.075,P=0.004,OR=3.674,95%CI:1.445-9.338)和HBV感染恢复组(0.230vs0.063,P=0.004,OR=4.468,95%CI:1.492-13.377)均显著增高,HLA-B*35,DRB1*13则显著降低(0.066vs0.163,P=0.027,OR=0.362,95%CI:0.143-0.918;0.016vs0.008,P=0.017,OR=0.174,95%CI:0.035-0.859);HLA-A*69,B*56也显著降低(均0.000vs0.037,P=0.031).HLA-A*02等位基因分布频率在慢性肝炎组与HBV感染恢复组比较显著降低(P=0.044),HLA-B*51在感染恢复组与正常组比较显著增高(P=0.019).结论:机体对HBV易感性和病毒持续或清除与HLA等位基因多态性相关.HLA-DRB1*12可能既为易感性位点,又能促进病毒的持续感染;HLA-B*51,A*02可能为易感性位点,但感染后易清除病毒;HLA-DRB1*13可能是抗HBV感染的保护性基因;HLA-B*35,B*56和A*69在中国北方汉族人可能也为抗HBV感染的保护性基因. | 张淑云 李迪 谷鸿喜 李兴库 金茜 刘伟 杜博 卢滨 | 2006 | 世界华人消化杂志2006，14，10： | 7 |
| 19 | 肿瘤坏死因子α基因多态性与慢性乙型肝炎病毒感染的相关性显示文摘乙型肝炎病毒(HBV)感染后临床表现的多样性,除与病毒因素有关,还与宿主的遗传因素密切相关。细胞因子在宿主清除病毒的免疫应答中发挥着重要作用,其基因多态性可影响细胞因子的整个转录,翻译和分泌过程,导致不同人群中细胞因子水平的差异,从而影响HBV感染后的转归。肿瘤坏死因子(TNF)α基因启动子区存在有多个多态性位点,分别为-1031(T/C)、-863(C/A)、-857(C/T)、-376(G/A)、-308(G/A)、-238(G/A)和-163(G/A)。 | 陈立 陈治新 潘晨 王小众 | 2006 | 中华肝脏病杂志2006，14，8： | 6 |
| 20 | 肿瘤坏死因子α与乙型肝炎病毒感染相关性的研究进展显示文摘乙型肝炎病毒(HBV)感染是全世界关注的卫生问题,目前全世界慢性HBV感染者近4亿且有广泛的疾病谱,包括无症状携带者、慢性肝炎、急性肝炎、肝功能衰竭、肝硬化。 | 高海兵 潘晨 | 2010 | 中国肝脏病杂志(电子版)2010，2，3： | 6 |
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