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| 1 | miR-30b inhibits autophagy to alleviate hepatic ischemiareperfusion injury via decreasing the Atg12-Atg5 conjugate显示文摘AIM: To explore the role and potential mechanism of miR-30 b regulation of autophagy in hepatic ischemiareperfusion injury(IRI).METHODS: An animal model of hepatic IRI was generated in C57BL/6 mice. For in vitro studies, AML12 cells were immersed in mineral oil for 1 h and then cultured in complete Dulbecco's Modified Eagle's Medium(DMEM)/F12 to simulate IRI. Mice and cells were transfected with miR-30 b agomir/mimics or antagomir/inhibitor to examine the effect of miR-30 b on autophagy to promote hepatic IRI. The expression of miR-30 b was measured by real-time polymerase chain reaction. Apoptotic cells were detected by terminal uridine nickend labeling(TUNEL) staining, and cell viability was detected by methylthiazole tetrazolium assay. The expression of light chain 3, autophagy-related gene(Atg)12, Atg5, P62, and caspase-3 were detected by western blotting analysis.RESULTS: miR-30 b levels were significantly downregulated after hepatic IRI, and the numbers of autophagosomes were increased in response to IRI both in vivo and in vitro. These findings demonstrate that low levels of miR-30 b could promote hepatic IRI. Furthermore, we found that miR-30 b interacted with Atg12-Atg5 conjugate by binding to Atg12. Overexpression of miR-30 b diminished Atg12 and Atg12-Atg5 conjugate levels, which promoted autophagy in response to IR. In contrast, downregulation of miR-30 b was associated with increased Atg12-Atg5 conjugate levels and increased autophagy.CONCLUSION: miR-30 b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. | Shi-Peng Li Jin-Dan He Zhen Wang Yao Yu Shu-Yu Fu Hai-Ming Zhang Jian-Jun Zhang Zhong-Yang Shen | 2016 | World Journal of Gastroenterology2016，22，18： | 19 |
| 2 | Further insight into the convergence of the Fletcher-Reeves method显示文摘The convergence properties of the Fletcher-Reeves method for unconstrained optimization are further studied with the technique of generalized line search. Two conditions are given which guarantee the global convergence of the Fletcher-Reeves method using generalized Wolfe line searches or generalized Arjimo line searches, whereas an example is constructed showing that the conditions cannot be relaxed in certain senses. | 戴彧虹 | 1999 | Science China Mathematics1999，42，9： | 16 |
| 3 | The preparation and characterization of folate-conjugated human serum albumin magnetic cisplatin nanoparticles显示文摘Objective:Nanoparticles are becoming an important method of targeted drug delivery.To evaluate the importance of folate-conjugated human serum albumin(HSA)magnetic nanoparticles(Folate-CDDP/HSA MNP),we prepared drug-loaded Folate-CDDP/HSA MNPs and characterized their features.Methods:First, folate was conjugated with HSA under the effect of a condensing agent,and the conjugating rate was evaluated by a colorimetric method using 2,4,6-trinitrobenzene sulfonic acid.Second,under N 2 gas,Fe 3 O 4 magnetic nanomaterials were prepared and characterized by using transmission electron microscopy(TEM),SEM-EDS and X-ray diffraction(XRD).Finally,Folate-CDDP/HSA MNP was prepared by using a solvent evaporation technique. TEM was used to observe particle morphology.The particle size and distribution of the prepared complexes were determined by a Laser particle size analyzer.Drug loading volume and drug release were investigated by a high performance liquid chromatography method(HPLC)in vitro.Results:We successfully prepared folate-conjugated HSA and its conjugating rate was 27.26μg/mg.Under TEM,Fe 3 O 4 magnetic nanoparticles were highly electron density and had an even size distribution in the range of 10-20 nm.It was confirmed by SEM-EDS and XRD that Fe 3 O 4 magnetic nanoparticles had been successfully prepared.Under TEM,drug-loaded magnetic nanoparticles were observed,which had a round shape,similar uniform size and smooth surface.Their average size was 79 nm which was determined by laser scattering,and they exhibited magnetic responsiveness.Encapsulation efficiency was 89.75%and effective drug loading was calculated to be 15.25%.The release results in vitro showed that the half release time(t1/ 2 )of cisplatin in cisplatin Solution and Folate-CDDP/HSA MNP was 65 min and 24 h respectively, which indicated that microspheres had an obvious effect of sustained-release.Conclusion:Folate-CDDP/HSA MNPs were prepared successfully.The preparation process and related characteristics data provided a foundation for further study,including the mechanism of the nanoparticles distribution in vivo and their intake by tumor cells. | Daozhen Chen Qiusha Tang Wenqun Xue Jingying Xiang Li Zhang Xinru Wang | 2010 | The Journal of Biomedical Research2010，24，1： | 13 |
| 4 | A REGULARIZED CONJUGATE GRADIENT METHOD FOR SYMMETRIC POSITIVE DEFINITE SYSTEM OF LINEAR EQUATIONS显示文摘AbstractA class of regularized conjugate gradient methods is presented for solving the large sparse system of linear equations of which the coefficient matrix is an ill-conditioned symmetric positive definite matrix. The convergence properties of these methods are discussed in depth, and the best possible choices of the parameters involved in the new methods are investigated in detail. Numerical computations show that the new methods are more efficient and robust than both classical relaxation methods and classical conjugate direction methods. | Zhong-zhi Bai Shao-liang Zhang | 2002 | Journal of Computational Mathematics2002，20，4： | 13 |
| 5 | Radon-Nikodym property of conjugate Banach spaces and w*-equivalence theorems of w*-u-measurable functions显示文摘A deep representation theorem of random conjugate spaces and its several important applications are given. As an application of the representation theorem, the following basic theorem is also proved: let B* be the conjugate space of a Banach space B, be a given probability space. Then every B*-valued w*-u-measurable function defined on is w*-equivalent to a B*-valued u-measurable function defined on if and only if B* has the Radon-Nikodym property with respect | 郭铁信 | 1996 | Science China Mathematics1996，39，10： | 11 |
| 6 | Conjugate Gradient Methods with Armijo-type Line Searches显示文摘Abstract Two Armijo-type line searches are proposed in this paper for nonlinear conjugate gradient methods.Under these line searches, global convergence results are established for several famous conjugate gradientmethods, including the Fletcher-Reeves method, the Polak-Ribiere-Polyak method, and the conjugate descentmethod. | Yu-Hong DAIState Key Laboratory of Scientific and Engineering Computing, Institute of Computational Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China | 2002 | Acta Mathematicae Applicatae Sinica2002，18，1： | 10 |
| 7 | Global convergence property of s-dependent GFR conjugate gradient method显示文摘An \%S\%_dependent GFR method and a generalized conjugate gradient method are designed. Two estimated values of upper bounds for the ratio of β k to β FR k are given. The two convergence theorems are proved. The global convergent properties of \%s\%_dependent GFR method are obtained adopting several choice strategies of steplength and some results in recent literature are extended. | WANG Changyu 1,2 and ZHANG Yuzhong\+1 1. Institute of Operations Research in Qufu Normal University, Qufu 273165, China 2. Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing 100080, China | 1998 | Chinese Science Bulletin1998，43，23： | 10 |
| 8 | Conjugate Gradient Algorithm in the Four-Dimensional Variational Data Assimilation System in GRAPES显示文摘Minimization algorithms are singular components in four-dimensional variational data assimilation(4DVar).In this paper,the convergence and application of the conjugate gradient algorithm(CGA),which is based on the Lanczos iterative algorithm and the Hessian matrix derived from tangent linear and adjoint models using a non-hydrostatic framework,are investigated in the 4DVar minimization.First,the influence of the Gram-Schmidt orthogonalization of the Lanczos vector on the convergence of the Lanczos algorithm is studied.The results show that the Lanczos algorithm without orthogonalization fails to converge after the ninth iteration in the 4DVar minimization,while the orthogonalized Lanczos algorithm converges stably.Second,the convergence and computational efficiency of the CGA and quasi-Newton method in batch cycling assimilation experiments are compared on the 4DVar platform of the Global/Regional Assimilation and Prediction System(GRAPES).The CGA is 40%more computationally efficient than the quasi-Newton method,although the equivalent analysis results can be obtained by using either the CGA or the quasi-Newton method.Thus,the CGA based on Lanczos iterations is better for solving the optimization problems in the GRAPES 4DVar system. | Yongzhu LIU Lin ZHANG Zhihua LIAN | 2018 | Journal of Meteorological Research2018，32，6： | 9 |
| 9 | Representation theorems of the dual of Lebesgue-Bochner function spaces显示文摘By representing random conjugate spaces a general representation theorem on classical duals is proved. For application, we unify and improve many known important representation theorems of the dual of Lebesgue-Bochner function spaces. | 郭铁信 | 2000 | Science China Mathematics2000，43，3： | 8 |
| 10 | Characterization and in vitro release studies of oral microbeads containing thiolated pectin–doxorubicin conjugates for colorectal cancer treatment显示文摘Novel oral microbeads were developed based on a biopolymer–drug conjugate of doxorubicin(DOX) conjugated with thiolated pectin via reducible disulfide bonds. The microbeads were fabricated by ionotropic gelation with cations such as Al3+, Ca2+ and Zn2+. The results showed that using zinc acetate can produce the strongest microbeads with spherical shape.However, the microbeads prepared from thiolated pectin–DOX conjugate were very soft and irregular in shape. To produce more spherical microbeads with suitable strength, the native pectin was then added to the formulations. The particle size of the microbeads ranged from 0.87 to 1.14 mm. The morphology of the microbeads was characterized by optical and scanning electron microscopy. DOX was still in crystalline form when used in preparing the microbeads, as confirmed by powder X-ray diffractometry. Drug release profiles showed that the microbeads containing thiolated pectin–DOX conjugate exhibited reduction-responsive character;in reducing environments, the thiolated pectin–DOX conjugate could uncouple resulting from a cleavage of the disulfide linkers and consequently release the DOX. The best-fit release kinetics of the microbeads containing thiolated pectin–DOX conjugate, in the medium without reducing agent, fit the Korsmeyer–Peppas model while those in the medium with reducing agent fit a zero-order release model. These results suggested that the microbeads containing thiolated pectin–DOX conjugate may be a promising platform for cancer-targeted delivery of DOX, exploiting the reducing environment typically found in tumors. | Kamonrak Cheewatanakornkool Sathit Niratisai Somkamol Manchun Crispin R.Dass Pornsak Sriamornsak | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 6 |
| 11 | Full-space Cloud of Random Points with a Scrambling Metasurface显示文摘With the rapid progress in computer science,including artificial intelligence,big data and cloud computing,full-space spot generation can be pivotal to many practical applications,such as facial recognition,motion detection,augmented reality,etc.These opportunities may be achieved by using diffractive optical elements(DOEs)or light detection and ranging(LIDAR).However,DOEs suffer from intrinsic limitations,such as demanding depth-controlled fabrication techniques,large thicknesses(more than the wavelength),Lambertian operation only in half space,etc.LIDAR nevertheless relies on complex and bulky scanning systems,which hinders the miniaturization of the spot generator.Here,inspired by a Lambertian scatterer,we report a Hermitian-conjugate metasurface scrambling the incident light to a cloud of random points in full space with compressed information density,functioning in both transmission and reflection spaces.Over 4044 random spots are experimentally observed in the entire space,covering angles at nearly 90°.Our scrambling metasurface is made of amorphous silicon with a uniform subwavelength height,a nearly continuous phase coverage,a lightweight,flexible design,and low-heat dissipation.Thus,it may be mass produced by and integrated into existing semiconductor foundry designs.Our work opens important directions for emerging 3D recognition sensors,such as motion sensing,facial recognition,and other applications. | Zile Li Qi Dai Muhammad Q.Mehmood Guangwei Hu Boris Luk’yanchuk Jin Tao Chenglong Hao Inki Kim Heonyeong Jeong Guoxing Zheng Shaohua Yu Andrea Alù Junsuk Rho Cheng-Wei Qiu | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 12 | Construction of energy transfer model of C-phycocyanin and allophycocyanin from Spirulina platensis显示文摘PHYCOBILIPROTEINS. which include phycoerythrin, phycocyanin, phycoerythroeyanin and allophycocyanin, are intensively coloured, highly fluorescent, water soluble chromoproteins. They are composed of at least two dissimilar polypeptides, α and β subunits, in a molar ratio of 1:1. The subunits possess linear tetrapyrrole prosthetic groups covalently linked to the primary structure via cysteine thioether linkages. In blue-green and red algae, phycobiliproteins occur in a supramolecular structure, the phycobilisome, located on the surface of thylakoid to | Wang, GC Zhou, BC Zeng, CK | 1997 | Chinese Science Bulletin1997，42，1： | 6 |
| 13 | Antibody drug conjugate:the“biological missile”for targeted cancer therapy显示文摘Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical linker.It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer drugs.Since the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far worldwide.Moreover,over 100 ADC candidates have been investigated in clinical stages at present.This kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer therapy.Herein,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs.Moreover,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs. | Zhiwen Fu Shijun Li Sifei Han Chen Shi Yu Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 14 | NEW HYBRID CONJUGATE GRADIENT METHOD AS A CONVEX COMBINATION OF LS AND FR METHODS显示文摘In this paper, we present a new hybrid conjugate gradient algorithm for unconstrained optimization. This method is a convex combination of Liu-Storey conjugate gradient method and Fletcher-Reeves conjugate gradient method. We also prove that the search direction of any hybrid conjugate gradient method, which is a convex combination of two conjugate gradient methods, satisfies the famous D-L conjugacy condition and in the same time accords with the Newton direction with the suitable condition. Furthermore, this property doesn't depend on any line search. Next, we also prove that, moduling the value of the parameter t,the Newton direction condition is equivalent to Dai-Liao conjugacy condition.The strong Wolfe line search conditions are used.The global convergence of this new method is proved.Numerical comparisons show that the present hybrid conjugate gradient algorithm is the efficient one. | Sne?ana S.DJORDJEVI? | 2019 | Acta Mathematica Scientia2019，39，1： | 5 |
| 15 | CONVERGENCE PROPERTIES OF CONJUGATEGRADIENT METHODS WITH STRONG WOLFE LINESEARCH显示文摘In this paper, we investigate the convergence property of the conjugate gradientalgorithms which depend on the search directionsby using different choices for the scalar oh, where 9k is the gradient of f at ac. Undersome assumptions which are slightly weaker than those in [1], we prove a global convergenceresult which allows ac to be set in a wider range than that in [1]. | HAN Jiye LIU Guanghui YIN Hongxia(Institute of Applied Mathematics, Academia Silica, Beijing 100080, China) | 1998 | Systems Science and Mathematical Sciences1998，11，2： | 5 |
| 16 | A NOTE ON THE NONLINEAR CONJUGATE GRADIENT METHOD显示文摘The conjugate gradient method for unconstrained optimization problems varies with a scalar. In this note, a general condition concerning the scalar is given, which ensures the global convergence of the method in the case of strong Wolfe line searches. It is also discussed how to use the result to obtain the convergence of the famous Fletcher-Reeves, and Polak-Ribiere-Polyak conjugate gradient methods. That the condition cannot be relaxed in some sense is mentioned. | Dai, Yu-hong Yuan, Ya-xiang | 2002 | Journal of Computational Mathematics2002，20，6： | 5 |
| 17 | Analysis and Design of Conjugate Cam Shedding Mechanism with Dual Driving Shafts显示文摘The principle of conjugate cam shedding mechanism forthe outside tappets with dual driving shafts is discussed,and its design conditions and parameters are studied,giving the results of practical calculations finally. | 蒋秀明 | 1998 | Journal of China Textile University(English Edition)1998，15，1： | 5 |
| 18 | 基于数据矩阵重构的相干源波达方向共轭ESPRIT(C-SPRIT)估计方法显示文摘本文提出了一种相干源波达方向估计算法.该方法利用C-SPRIT思想,通过构造数据矩阵,使得无论是否存在相干信号,均能很好估计信号波达方向(DOA).传统的空间平滑技术通过子阵平滑来解决相干源DOA估计问题,但信号之间并没有完全解相干,孔径损失也很大,且最多只能估计2N/3个相干源(N为阵元数目).本文方法也采用空间平滑去相干的思想,但无孔径损失,信号之间完全解相关,提高了相干源DOA估计精度,并且能估计N-1个相干源,该方法利用ESPRIT数值求解进行角度估计,无需角度搜索,运算量小,计算机仿真验证了该方法的有效性和优越性. | 朱圣棋 廖桂生 周争光 | 2009 | 电子学报2009，37，12： | 5 |
| 19 | Inhibitory effect of humanized anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma:in vitro and in vivo studies显示文摘Objective:To investigate the inhibitory effect of humanized anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma both in vitro and in vivo,which may be a potential agents with sensitivity and targeting ability for human hepatocellular cancer.Methods:Humanized anli-VECFR-2 ScFv-As_2O_3-stealth nanoparticles conjugate was previously constructed using ribosome display technology and antibody conjugate technology.In this combined in vitro and in vivo study,the inhibitory effects of anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles conjugate on tumor growth,invasion,and metastasis was observed with human liver carcinoma cell line Bel7402 and normal cell L02 by MTT assay,Tanswell assay,Hochest33258 staining,and DNA ladder analysis.The anticancer activity and distribution of anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles was then verified in a mouse model of Bel7402xenografts.Results:Anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles significantly inhibited the proliferation of Bel7402 in the 3-(4,5-dimethylthiazol-2-yh-2,5-diphenyltetrazolium bromide assay while had almost no effects on L02 cells.And the apoptosis inducing effects were proved by Hochest33258 staining and DNA ladder analysis.Transwell assay found that the drug also inhibited the metastasis ability of tumor cells.Furthermore,anti-VEGFR-2 ScFv-As^-stealth nanoparticles significantly delayed the growth of Bel7402 xenografts after administration(92.9%),followed by As_2O_3-stealth nanoparticles,anti-VEGFR-2 ScFv,and As203(61.4%,58.8%,20.5%,P<0.05).The concentration of As_2O_3 in anti-VEGFR-2 ScFv-As_2O_3-steallh nanoparticles group was more selectively.Conclusions:Anti-VEGFR-2 ScFv-As_2O_3-stealth nanoparticles is a potent and selective anti-hepatocellular carcinoma agent which could inhibit the growth of liver cancer as a targeting agent both in vitro and in vivo and also significantly inhibit angiogenesis. | Xiang-Bao Yin Lin-Quan Wu Hua-Qun Fu Ming-Wen Huang Kai Wang Fan Zhou Xin Yu Kai-Yang Wang | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，5： | 5 |
| 20 | A theoretical analysis on efficiency of some Newton-PCG methods显示文摘In this paper, we study the efficiency issue of inexact Newton-type methods for smooth unconstrained optimization problems under standard assumptions from theoretical point of view by discussing a concrete Newton-PCG algorithm. In order to compare the algorithm with Newton's method, a ratio between the measures of their approximate efficiencies is investigated. Under mild conditions, it is shown that first, this ratio is larger than 1, which implies that the Newton-PCG algorithm is more efficient than Newton's method,and second, this ratio increases when the dimension n of the problem increases and tends to infinity at least at a rate ln n/ln 2 when n →∞, which implies that in theory the NewtonPCG algorithm is much more efficient for middle- and large-scale problems. These theoretical results are also supported by our preliminary numerical experiments. | DENG Naiyang, ZHANG Jianzhong & ZHONG Ping China Agricultural University, Beijing 100083, China City University of Hong Kong, Hong Kong, China | 2005 | Science China Mathematics2005，48，8： | 4 |
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