|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 羊水栓塞临床诊断与处理专家共识(2018)显示文摘羊水栓塞(amniotic fluid embolism,AFE)是产科特有的罕见并发症,其临床特点为起病急骤、病情凶险、难以预测,可导致母儿残疾甚至死亡等严重的不良结局。中华医学会妇产科学分会产科学组结合国内外文献,参考美国母胎医学会(Society for Maternal.Fetal Medicine,SMFM)“AFE指南”[1]等,根据我国的临床实践制定了本共识,旨在提高及规范AFE诊断和抢救治疗能力,以改善孕产妇和围产儿结局。 | 中华医学会妇产科学分会产科学组 古航 | 2018 | 中华妇产科杂志2018，53，12： | 93 |
| 2 | 对“新产程标准及处理的专家共识(2014)”的理解和说明显示文摘2014年中华医学会妇产科学分会产科学组参考美国妇产科医师协会(American College of Obstetricians and Gynecologists,ACOG)和美国母胎医学会(Society for Maternal—Fetal Medicine,SMFM)的专家共识,发布了“新产程标准及处理的专家共识(2014)”(简称:新产程专家共识), | 无 | 2018 | 中华妇产科杂志2018，53，2： | 33 |
| 3 | 重新认识和正确评价胎儿电子监护显示文摘近年来,胎儿电子监护(electronic fetal monitoring,EFM)在产前和产时的应用越来越广泛,已经成为产科医生不可缺少的辅助检查手段。美国1980年产时胎心监护的使用率为45%,1988年为62%,1992年为74%,2002年达85%,现在几乎所有产科保健机构均能进行EFM。临床研究证据表明,EFM增加了剖宫产率和阴道助产率,主要原因在于其有效性、观察者诠释的个体差异、对评价系统以及处理方法的认识不同, | 王子莲 陈海天 | 2010 | 中华围产医学杂志2010，13，1： | 20 |
| 4 | Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?显示文摘Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and cognition.Clinical guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic encephalopathy.The clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong evidence.There are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic encephalopathy.Preclinical studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of hypothermia.In this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes. | Anthony Davies Guido Wassink Laura Bennet Alistair J.Gunn Joanne O.Davidson | 2019 | Neural Regeneration Research2019，14，10： | 20 |
| 5 | 新生儿持续肺动脉高压显示文摘新生儿持续肺动脉高压 ( persistent pulmonary hypertension of the newborn, PPHN)于1969年被首次认识,当时因考虑其血流动力学改变类似于胎儿循环,故称为持续胎儿循环 ( persistent fetal circulation,PFC),但由于主要病因是生后肺动脉压力的持续增高,故现在多将其称为新生儿持续肺动脉高压,即PPHN。该病是指新生儿出生后由于一种或多种病因导致肺血管阻力持续性增高,胎儿型循环向正常“成人型”循环过渡受到阻碍,当肺循环压力超过体循环压力时,心房及(或)动脉导管水平出现血液的右向左分流,临床上以严重的低氧血症为主要表现。本病是新生儿期发病和死亡的主要原因之一,多见于足月儿或过期产儿。 | 杜军保 石云 | 2006 | 中国新生儿科杂志2006，21，3： | 19 |
| 6 | 胎儿生长受限的影响因素显示文摘胎儿生长受限(fetal growth restriction,FGR)是产科常见的并发症之一,通常与早产、胎死宫内、新生儿死亡等不良结局相关,美国和欧洲的发生率为5%~15%,发展中国家的发生率为10%~55%,其中东南亚发生率最高,而我国的发生率接近发达国家[1-3]。FGR是围产儿死亡的第二位原因,仅次于早产。此外,FGR的胎儿成年后发生心血管疾病、代谢疾病的风险增高[4]。 | 王萌璐 陈倩 | 2019 | 发育医学电子杂志2019，7，1： | 17 |
| 7 | 超声估测胎儿体重的研究进展显示文摘胎儿体重是反映胎儿生长发育、宫内异常妊娠情况的重要指标,是临床医师为孕妇选择正确分娩方式和制订胎儿宫内诊疗方案的参考依据。准确估测胎儿体重(estimated fetal weight,EFW)可及时发现胎儿生长受限,为进一步诊治和降低围生儿病死率有重要意义。 | 唐慧霞 李胜利 | 2014 | 中华医学超声杂志(电子版)2014，11，5： | 16 |
| 8 | Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy显示文摘Cell-based regenerative medicine is of growing interest in biomedical research. The role of stem cells in this context is under intense scrutiny and may help to define principles of organ regeneration and develop innovative therapeutics for organ failure. Utilizing stem and progenitor cells for organ replacement has been conducted for many years when performing hematopoietic stem cell transplantation. Since the first successful transplantation of umbilical cord blood to treat hematological malignancies, non-hematopoietic stem and progenitor cell populations have recently been identified within umbilical cord blood and other perinatal and fetal tissues. A cell population entitled mesenchymal stromal cells (MSCs) emerged as one of the most intensely studied as it subsumes a variety of capacities: MSCs can differentiate into various subtypes of the mesodermal lineage, they secrete a large array of trophic factors suitable of recruiting endogenous repair processes and they are immunomodulatory.Focusing on perinatal tissues to isolate MSCs, we will discuss some of the challenges associated with these cell types concentrating on concepts of isolation and expansion, the comparison with cells derived from other tissue sources, regarding phenotype and differentiation capacity and finally their therapeutic potential. | Karen Bieback Irena Brinkmann | 2010 | World Journal of Stem Cells2010，2，4： | 15 |
| 9 | 胎儿生长受限的病因显示文摘胎儿生长受限(fetal growth restriction,FGR)/胎儿宫内发育迟缓(in utero growth restriction,IUGR)是指胎儿受各种不利因素的影响,如遗传、环境、营养、疾病等因素,未能达到其潜在所应有的生长速率。根据美国妇产科医师学会(The American College of Obstetricians and Gynecologists, | 陈燕君 周袆 | 2017 | 中国医刊2017，52，5： | 14 |
| 10 | Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies显示文摘Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient β-globin synthesis leading to β-thalassemia.These two major forms of β-hemoglobinopathies cause impaired erythropoiesis and life-threatening anemia.Clinical evidence has suggested that reaaivation of fetal γ-globin(HBG)gene expression which is normally silenced after birth by certain genetic mutations can ameliorate the clinical course of β-hemoglobinopathies. | Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li | 2020 | Cell Research2020，30，3： | 14 |
| 11 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 12 | 一氧化氮吸入治疗在新生儿重症监护病房的应用指南(2019版)显示文摘胎儿肺循环阻力较体循环阻力高,呈肺动脉高压(pulmonary arterial hypertension,PAH)状况。新生儿出生后血液循环从“胎儿型”过渡至正常“成人型”,肺循环压力和阻力下降,但有多种疾病可引起此过程障碍或逆转,致肺血管阻力持续增高,伴有体循环血管阻力正常或者下降,肺动脉压超过体循环动脉压,动脉导管和(或)卵圆孔水平右向左分流持续存在,称为新生儿持续性肺动脉高压(persistent pulmonary hypertension of newborn,PPHN),又称为持续胎儿循环(persistent fetal circulation,PFC),表现为机体持续缺氧和发绀,最终导致危及生命的循环、呼吸衰竭[1-3]。 | 无 洪小杨 花少栋 孔祥永 岳少杰 吴本清 刘志伟 周伟 封志纯 | 2019 | 发育医学电子杂志2019，7，4： | 13 |
| 13 | 胎儿生长受限的诊治显示文摘胎儿生长受限(fetal growth restriction,FGR),其新生儿无论足月或早产,死亡率与患病率均显著升高,且远期不良结局如儿童时期的认知障碍、成人时期疾病等发生风险增加。2019年美国妇产科医师学会(ACOG)发布了关于FGR的实践指南,我国发布了《胎儿生长受限专家共识(2019版)》(以下简称专家共识)。本文将结合指南对FGR的诊治做文献复习并对一些临床问题进行探讨。 | 蒋晨昱 鲍晨怡 刘兴会 | 2020 | 实用妇产科杂志2020，36，3： | 13 |
| 14 | 胎儿先天性心脏病的超声诊断分析显示文摘胎儿先天性心脏病(fetal congenital heart disease,FCHD)为临床常见的先天性畸形,文献[1]报道其发生率约0.8%,因此造成的新生儿死亡率可达3.0%,产前准确诊断对于FCHD围生期及新生儿期患儿的处理和治疗有着重要意义。超声作为无创性检查,是诊断FCHD的首要影像学检查手段,本研究通过回顾性分析134例FCHD的临床资料及超声声像图,旨在探讨FCHD的超声诊断特点及分型价值。资料与方法一、临床资料选取2006年4月至2013年12月我院妇产科FCHD 134例,其中71例经引产手术后尸检病理证实, | 张喻 安培莉 王颖金 侯小霞 | 2015 | 临床超声医学杂志2015，17，12： | 13 |
| 15 | 产时宫内复苏的临床应用显示文摘产时宫内复苏(intrauterine fetal resuscitation)是指为改善产时胎儿氧供而使用的一系列措施,包括:改变体位、吸氧、静脉补液及使用宫缩抑制剂等。对于产时胎儿健康状况的评估主要来自胎心监护,目前国外胎心监护相关指南”、把胎心监护图形分为3类,对于Ⅱ类及Ⅲ类图形,可使用产时宫内复苏措施后再重新评估,这些措施可能通过改善胎儿氧供而纠正或改善异常的胎心监护图形,为继续阴道试产提供依据,也为行阴道助产或剖宫产争取时间。对于胎心监护图形判断及产时宫内复苏措施的实施,建立在对母体胎儿之间氧输送生理机制充分了解的基础上。现对胎儿氧输送的生理机制及产时宫内复苏措施讲解如下。 | 王晔 刘铭 | 2016 | 中华妇产科杂志2016，51，3： | 12 |
| 16 | Safety of endoscopic retrograde cholangiopancreatography in pregnancy: Fluoroscopy time and fetal exposure, does it matter?显示文摘AIM: To estimate the fetal radiation exposure using thermoluminescent dosimeters (TLD's) in pregnant patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and assess its relevance. METHODS: Data on thirty-five therapeutic ERCPs conducted in pregnant patients from 2001 to 2009 were retrieved from a prospective database. Techniques to minimize fluoroscopy time were implemented and the fluoroscopy times captured. TLD's were placed on the mother to estimate the fetal radiation exposure and the results were compared to the maximum allowed dose of radiation to the fetus [0.005 gray (Gy)]. Obstetrics consultations were obtained and the fetus was monitored before and after the ERCP. Fluoroscopy wasperformed at 75 kVp. ERCP was performed with the patients supine by dedicated biliary endoscopists performing more than 500 cases a year. RESULTS: A total of 35 pregnant patients underwent ERCP and biliary sphincterotomy (14 in first trimester, 11 in second trimester, and 10 in third trimester). Mean maternal age was 25 years (range 16-37 years) and mean gestational age was 18.9 wk (range 4-35 wk). Mean fluoroscopy time was 0.15 min (range 0-1 min). For 23 women, the estimated fetal radiation exposure was almost negligible (< 0.0001 Gy) while for 8 women, it was within the 0.0001-0.0002 Gy range. Three women had an estimated fetal radiation exposure between 0.0002 and 0.0005 Gy and 1 woman had an estimated fetal radiation exposure greater than 0.0005 Gy. Complications included 2 post-sphincterotomy bleeds, 2 post-ERCP pancreatitis, and 1 fatal acute respiratory distress syndrome. One patient developed cholecystitis 2 d after ERCP. CONCLUSION: ERCP with modified techniques is safe during pregnancy, and estimating the fetal radiation exposure from the fluoroscopy time or measuring it via TLD's is unnecessary. | Ioana Smith Monica Gaidhane Allen Goode Michel Kahaleh | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 12 |
| 17 | Sonographic markers for early diagnosis of fetal malformations显示文摘Fetal malformations are very frequent in industrialized countries.Although advanced maternal age may affect pregnancy outcome adversely,80%-90%of fetal malformations occur in the absence of a specific risk factor for parents.The only effective approach for prenatal screening is currently represented by an ultrasound scan.However,ultrasound methods present two important limitations:the substantial absence of quantitative parameters and the dependence on the sonographer experience.In recent years,together with the improvement in transducer technology,quantitative and objective sonographic markers highly predictive of fetal malformations have been developed.These markers can be detected at early gestation(11-14 wk)and generally are not pathological in themselves but have an increased incidence in abnormal fetuses.Thus,prenatal ultrasonography during the second trimester of gestation provides a'genetic sonogram',including,for instance,nuchal translucency,short humeral length,echogenic bowel,echogenic intracardiac focus and choroid plexus cyst,that is used to identify morphological features of fetal Down’s syndrome with a potential sensitivity of more than 90%.Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal anomalies.In the future,sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis(amniocentesis,etc.). | Maria Daniela Renna Paola Pisani Francesco Conversano Emanuele Perrone Ernesto Casciaro Gian Carlo Di Renzo Marco Di Paola Antonio Perrone Sergio Casciaro | 2013 | World Journal of Radiology2013，5，10： | 12 |
| 18 | Placental-derived stem cells:Culture, differentiation and challenges显示文摘Stem cell therapy is a promising approach to clinical healing in several diseases. A great variety of tissues(bone marrow, adipose tissue, and placenta) arepotentially sources of stem cells. Placenta-derived stem cells(p-SCs) are in between embryonic and mesenchymal stem cells, sharing characteristics with both, such as non-carcinogenic status and property to differentiate in all embryonic germ layers. Moreover, their use is not ethically restricted as fetal membranes are considered medical waste after birth. In this context, the present review will be focused on the biological properties, culture and potential cell therapy uses of placental-derived stem cells. Immunophenotype characterization, mainly for surface marker expression, and basic principles of p-SC isolation and culture(mechanical separation or enzymatic digestion of the tissues, the most used culture media, cell plating conditions) will be presented. In addition, some preclinical studies that were performed in different medical areas will be cited, focusing on neurological, liver, pancreatic, heart, muscle, pulmonary, and bone diseases and also in tissue engineering field. Finally, some challenges for stem cell therapy applications will be highlighted. The understanding of the mechanisms involved in the p-SCs differentiation and the achievement of pure cell populations(after differentiation) are key points that must be clarified before bringing the preclinical studies, performed at the bench, to the medical practice. | Maira S Oliveira Joao B Barreto-Filho | 2015 | World Journal of Stem Cells2015，7，4： | 10 |
| 19 | 产时电子胎心监护的认识显示文摘 | 漆洪波 | 2008 | 中华妇幼临床医学杂志(电子版)2008，4，2： | 9 |
| 20 | 分娩期电子监护显示文摘 | 程志厚 关红琼 李升莲 | 2005 | 中国实用妇科与产科杂志2005，21，5： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员