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| 1 | Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis,treatment, and outcomes显示文摘Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS between the West and China, clinical profiles, imaging findings, treatment, and outcomes of HSOS associated with hematopoietic stem cell transplantation or oxaliplatin might be hardly extrapolated to PAs-induced HSOS. Reactive metabolites derived from PAs form pyrrole-protein adducts that result in toxic destruction of hepatic sinusoidal endothelial cells. PAs-induced HSOS typically manifests as painful hepatomegaly, ascites, and jaundice. Laboratory tests revealed abnormal liver function tests were observed in most of the patients with PAs-induced HSOS. In addition, contrast computed tomography and magnetic resonance imaging scan show that patients with PAs-induced HSOS have distinct imaging features, which reveal that radiological imaging provides an effective noninvasive method for the diagnosis of PAs-induced HSOS. Liver biopsy and histological examination showed that PAs-induced HSOS displayed distinct features in acute and chronic stages. Therapeutic strategies for PAs-induced HSOS include rigorous fluid management, anticoagulant therapy, glucocorticoids, transjugular intrahepatic portosystemic shunt, liver transplantation, etc. The aim of this review is to describe the pathogenesis, clinical profiles, diagnostic criteria, treatment, and outcomes of PAs-induced HSOS. | Xiao-Qian Yang Jin Ye Xin Li Qian Li Yu-Hu Song | 2019 | World Journal of Gastroenterology2019，25，28： | 29 |
| 2 | Proton pump inhibitor for non-erosive reflux disease:A meta-analysis显示文摘AIM:To evaluate the efficacy,safety and influential factors of proton pump inhibitor(PPI)treatment for non-erosive reflux disease(NERD).METHODS:PubMed,MEDLINE,EMBASE and the Cochrane Library were searched up to April 2013 to identify eligible randomized controlled trials(RCTs)that probed into the efficacy,safety and influential factors of PPI treatment for NERD.The rates of symptomatic relief and adverse events were measured as the outcomes.After RCT selection,assessment and data collection,the pooled RRs and 95%CI were calculated.This meta-analysis was performed using the Stata 12.0 software(Stata Corporation,College Station,Texas,United States).The level of evidence was estimated by the Grading of Recommendations Assessment,Development and Evaluation system.RESULTS:Seventeen RCTs including 6072 patients met the inclusion criteria.The results of the metaanalysis showed that PPI treatment was significantly superior to H2receptor antagonists(H2RA)treatment(RR=1.629,95%CI:1.422-1.867,P=0.000)and placebo(RR=1.903,95%CI:1.573-2.302,P=0.000)for the symptomatic relief of NERD.However,there were no obvious differences between PPI and H2RA(RR=0.928,95%CI:0.776-1.110,P=0.414)or PPI and the placebo(RR=1.000,95%CI:0.896-1.116,P=0.997)regarding the rate of adverse events.The overall rate of symptomatic relief of PPI against NERD was 51.4%(95%CI:0.433-0.595,P=0.000),and relief was influenced by hiatal hernia(P=0.030).The adverse rate of PPI against NERD was 21.0%(95%CI:0.152-0.208,P=0.000),and was affected by hiatal hernia(P=0.081)and drinking(P=0.053).CONCLUSION:PPI overmatched H2RA on symptomatic relief rate but not on adverse rate for NERD.Its relief rate and adverse rate were influenced by hiatal hernia and drinking. | Ji-Xiang Zhang Meng-Yao Ji Jia Song Hong-Bo Lei Shi Qiu Jing Wang Ming-Hua Ai Jun Wang Xiao-Guang Lv Zi-Rong Yang Wei-Guo Dong | 2013 | World Journal of Gastroenterology2013，19，45： | 8 |
| 3 | Interleukin-6 and ratio of plasma interleukin-6/interleukin-10 as risk factors of symptomatic lumbar osteoarthritis显示文摘AIM To determine the role of cartilage oligomeric matrix protein(COMP), interleukin(IL)-6, IL-10 and ratio of IL-6/IL-10 as risk factors of symptomatic lumbar osteoarthritis(OA) in postmenopausal women with estrogen deficiency.METHODS Case-control study had been conducted in Sanglah General Hospital from October 2015 until March 2016. The blood samples were obtained and analyzed by enzyme-linked immunosorbent assay(ELISA).RESULTS From 44 pairs of samples which divided into 44 samples as case group and 44 samples as control group showed that high level of COMP in estrogen deficiency postmenopausal women were not at risk(OR = 0.7; 95%CI: 0.261-1.751; P = 0.393) for symptomatic lumbar OA(cut-off point 0.946). Estrogen deficiency in postmenopausal women with the high level of IL-6 had 2.7 times risk(OR = 2.7; 95%CI: 0.991-8.320; P = 0.033) for symptomatic lumbar OA from the low level of IL-6(cut-off point 2.264). At lower level of IL-10, there was no risk for symptomatic lumbar OA(OR = 0.6; 95%CI: 0.209-1.798; P = 0.345) than with the higher level of IL-10(cut-off point 6.049). While the high ratio of IL-6/IL-10 level in estrogen deficiency postmenopausal women gave 3.4 times risk(OR = 3.4; 95%CI: 1.204-11.787; P = 0.011)for symptomatic lumbar OA than the low ratio of IL-6/IL-10 level(cut-off point 0.364).CONCLUSION High ratio of IL-6/IL-10 plasma level was the highest risk factor for causing symptomatic lumbar OA in postmenopausal women with estrogen deficiency. | I Ketut Suyasa I Ketut Siki Kawiyana I Made Bakta I Gde Raka Widiana | 2017 | World Journal of Orthopedics2017，8，2： | 7 |
| 4 | 颈动脉斑块病理学:血栓、溃疡和卒中的发病机制 | Fisher M. Paganini-Hill A. Martin A. 赵正卿 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，7： | 6 |
| 5 | Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients显示文摘AIM: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease(NERD) patients.METHODS: Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance- p H on rabeprazole. The symptom index(SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter.RESULTS: In 14(40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes(46.7%) than in distal ones(5.7%)(P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(38.5%) and distal ones(20.5%)(NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent(31.0%) than in distal reflux ones(3.3%)(P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(29.4%) and distal ones(14.3%)(NS).CONCLUSION: The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy. | Kenichiro Nakagawa Tomoyuki Koike Katsunori Iijima Masahiro Saito Hiroki Kikuchi Waku Hatta Nobuyuki Ara Kaname Uno Naoki Asano Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，47： | 4 |
| 6 | Effect of 0.05% topical cyclosporine for the treatment of symptomatic subepithelial infiltrates due to adenoviral keratoconjunctivitis显示文摘Dear Sir,Iam Yonca A.Akova,MD-from the Department of Ophthalmology,Bayindir Kavaklidere Hospital,Turkey.I wrote this letter to evaluate the efficacy of 0.05%topical cyclosporine A(CsA)eye drops(Restasis Allergan,Irvine,USA)in symptomatic patients with recurrent subepithelial infiltrates(SEIs)due to adenoviral keratoconjunctivitis following steroid eye drops tapering or discontinuation. | Ilkay Kilic Muftuoglu Yonca A.Akova Sirel G.Gungor | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 2 |
| 7 | Gastrointestinal symptomatic outcomes of laparoscopic and open gastrectomy显示文摘AIM:To compare the laparoscopic and the open gastrectomy approaches for short term morbidity,length of hospital stay and also long term gastrointestinal symptoms.METHODS:Patients who have undergone gastrectomy had their medical records reviewed for demographic data,type of gastrectomy,short term morbidity,and length of hospital stay.Patients were contacted and asked to complete the Gastrointestinal Symptom Rating Scale(GSRS).The GSRS measures three domains of GI symptoms:Dyspepsia Syndrome(DS) for the foregut(best score 0,worse score 15),indigestion syndrome(IS) for the midgut(best score 0,worse score 12),and bowel dysfunction syndrome(BDS) for the hindgut(best score 0,worse score 16).Statistical analysis was done using the Mann-Whitney U-test.RESULTS:We had complete data on 32 patients:7 laparoscopic and 25 open.Of these,25 had a gastroenteric anastomosis and 6 did not.The table shows the results as medians with interquartile range.Laparoscopic gastrectomy had a better score than open gastrectomy in the DS domain(0 vs 1,P = 0.02),while gastrectomy without anastomosis had a better score than gastrectomy with anastomosis in the IS domain(0 vs 1,P = 0.05).CONCLUSION:Patients have little adverse gastroin-testinal symptoms and preserve good gastrointestinal function after undergoing any type of gastrectomy.Laparoscopic approach had better dyspepsia and foregut symptoms.Performing an anastomosis led to mild adverse midgut and indigestion | Bilal Kharbutli Vic Velanovich | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 1 |
| 8 | Electrophysiological evaluation of ulnar nerve in carpal tunnel syndrome显示文摘Objective To evaluate the impairment of ulnar nerve and its relationship with sensory symptoms in the ulnar territory in patients with carpal tunnel syndrome(CTS)through electrophysiological approach.Methods We retrospectively reviewed 55 cases with CTS admitted in our hospital from January 2012 to February 2013.Patients with CTS were graded as mild-moderate(35 cases)andsevere(20 cases)according to Stevens standard and were divided into symptomatic and non-symptomatic group | 刘娜 | 2014 | China Medical Abstracts(Internal Medicine)2014，31，1： | 1 |
| 9 | Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1显示文摘Background:Recent genome-wide association studies have identified an important role of T-cell receptor α(TRA) gene in the development of narcolepsy type 1.However,the role of TRA haplotype polymorphisms in the symptomatic diversity of narcolepsy remains unclear.This study aimed to investigate whether TRA polymorphisms can influence the symptomatic diversity of narcolepsy.Methods:Totally,903 patients with narcolepsy type 1 were included in the study.Patients were divided into different groups according to their symptoms.First,13 genotyped single nucleotide polymorphisms in the TRA were assessed for their association with symptoms of narcolepsy.We used the Chi-square test to determine differences in genotype frequencies in patients with narcolepsy.Further,we identified the haplotypes and variations of the TRA and tested their association with the symptoms of narcolepsy using a logistic regression model.Results:According to the results of the logistic regression,TRA haplotypes TG and CT were significantly associated with auditory hallucination,with odds ratios of 1.235 (95% confidence interval [CI],1.012-1.507) and 1.236 (95% CI,1.012-1.511),respectively (P < 0.05).Contusions:The patterns of haplotype in TRA (haplotypes TG and CT) are associated with hypnagogic auditory hallucination in patients with narcolepsy type 1.However,further studies are needed to confirm our results and explore the underlying mechanisms. | Hui Ouyang Fang Han Ze-Chen Zhou Qi-Wen Zheng Yang-Yang Wang Jun Zhang | 2019 | Chinese Medical Journal2019，，15： | 1 |
| 10 | Discussion on depression by thinking of t raditional Chinese medicine显示文摘Depression is a common mental disease characterized by abnormal emotional changes,which belongs to the category of“melancholia syndrome”and Chinese emotion medicine.The main clinical manifestations are mood depression,loss of interest,hallucinations,self-harm,and even suicide.Etiology and pathogenesis can be divided into“inner depression”and“outer depression”,and is related to the susceptibility of the constitution.The diagnosis can be combined with four diagnoses and new techniques.Traditional Chinese medicine(TCM)treatment methods include TCM,psychotherapy,acupuncture,music therapy and so on.TCM treatment of depression has a long history,strong symptomatic,little side effects.It is forward-looking to explore new ideas of understanding and treating depression syndrome with TCM theory,which is helpful to better“prevention before disease”.TCM therapy will certainly play an important role in the treatment of depression in the future. | Yi-Tong Huang Cong-Cong Chang | 2023 | Medical Theory and Hypothesis2023，6，1： | 0 |
| 11 | CLINICAL APPLICATION OF TRADITIONAL AURICULOACUPOINT THERAPY(Continued)显示文摘TREATMENT OF VASCULARHYPERTENSIONVascular hypertension is a chronic dis-order with elevated blood pressure in the ar-teries.It can be classified into the primarytype and the secondary type:the former,representing 80-90% of all cases,is due tofunctional disturbance of the central nerv-ous system and the blood vascular motorcenter;while the latter is symptomatic ofother diseases,such as compromised renalperfusion,arteriosclerosis,or intracranialtumors.Early primary vascular | 陈抗美 周淑莲 郑英 | 1993 | Journal of Traditional Chinese Medicine1993，13，2： | 0 |
| 12 | Effects of Chaihu Guizhi Ganjiang Decoction Combined with Standard Triple Therapy on Reducing Serum CagA and Hp-NAP in Patients with H.pylori-Related Gastritis显示文摘OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction. The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay(ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention(P > 0.05). After intervention, CagA and Hp-NAP concentrations in experimental group were(19.21±6.27) ng/L and(24.37±6.10) ng/L respectively which were lower than(25.81±7.14) ng/L and(32.09±5.73) ng/L of control group. The differences were statistically significant(P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases(95.12%), which was significantly higher than that of the control group(31 cases, 75.61%). There was statistically significant difference between the 2 groups(P < 0.05). The eradication rate of H.pylori was 38 cases(92.68%) in the experimental group, which was significantly higher than 31 cases(75.61%) of the control group. The difference between the 2 groups was statistically significant(P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis, improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion. | 杨为霞 王金华 陈兆洋 张凤 | 2018 | World Journal of Integrated Traditional and Western Medicine2018，4，4： | 0 |
| 13 | Clinical profile and risk factors of symptomatic and asymptomatic hypoglycemia in neonates admitted to NICU in a tertiary care center: A cross-sectional study显示文摘Objective:To investigate the clinical profile and risk factors of symptomatic and asymptomatic hypoglycemia in neonates admitted to a neonatal intensive care unit in a tertiary care center.Methods:The prospective observational study was conducted in a tertiary care center in the Specialty Department of Pediatric.196 Newborn babies with blood glucose levels<45 mg/dL were examined with a simple random sampling method between December 2019 and November 2021.Maternal and neonatal risk factors and clinical signs were recorded and compared between symptomatic and asymptomatic cases.Results:The proportion of symptomatic hypoglycemia neonates born to gestational diabetes mellitus mothers was significantly higher(23.4%vs.8.4%)(P<0.05).Small for gestational age,low birth weight,respiratory distress syndrome,hypothermia,and endocrine disorders were risk factors.The death rate in asymptomatic hypoglycemia neonates was significantly higher(58%vs.39%)(P<0.05).Conclusions:The study indicates that maternal gestational diabetes mellitus is associated with symptomatic hypoglycemia and asymptomatic hypoglycemia is associated with neonatal mortality.It is important to take vigilance and timely interventions to address associated symptoms,particularly poor feeding,in the management of neonatal hypoglycemia. | Kiran Bhojraj Bhaisare Shivprasad Kachrulal Mundada Nehal Bharat Shah | 2024 | Journal of Acute Disease2024，13，1： | 0 |
| 14 | Analyses of triggers for recurrent cardiac events in 38 patients with symptomatic long QT syndrome显示文摘Objective To evaluate the main triggers of recurrent cardiac events in patients with symptomatic congenital long QT syndrome(cLQTS).Methods In this retrospective case analysis study,clinical characteristics were reviewed from 38 patients with recurrent cardiac events after first visit out of 66 symptomatic cLQTS patients.General clinical data such as gender,age,clinical presentation,family history and treatment were collected,auxiliary examination results such as electrocardiogram and gene detection were analyzed. | 李锟 | 2021 | China Medical Abstracts(Internal Medicine)2021，38，2： | 0 |
| 15 | Impacts of acupuncture on blood pressure and hematoma in patients of cerebral hemorrhage at the early stage显示文摘Objective To explore the therapeutic effect of acupuncture for hypertensive cerebral hemorrhage at the early stage.Methods Fifty-four cases of small-amount cerebral hemorrhage were randomized into an acupuncture group and a conventional treatment group,27 cases in each.In the conventional treatment group,special care,oxygen therapy,nerve nutrition and symptomatic support were applied.If necessary,dehydrant and hypotensive drugs were prescribed for antihypertension,or | 陶文强 | 2014 | China Medical Abstracts(Internal Medicine)2014，31，3： | 0 |
| 16 | Laws of syndrome types of Chinese medicine in dyslipidemia patients显示文摘Objective To observe changing laws of syndrome types of Chinese medicine(CM)in dyslipidemia patients.Methods Totally 439 dyslipidemia patients were recruited.Their syndrome types of CM and blood lipids were observed at the baseline(at the first visit),1st interview(at week 4),2nd interview(at week 8),and | 孙明月 | 2017 | China Medical Abstracts(Internal Medicine)2017，34，1： | 0 |
| 17 | Laparoscopic fenestration of pancreatic serous cystadenoma:Minimally invasive approach for symptomatic benign disease显示文摘Serous cystadenoma(SC) is a benign pancreatic cystic tumor. Surgical resection is recommended for symptomatic forms, but laparoscopic fenestration of large symptomatic macrocystic SC was not yet described in the literature. In this study, 3 female patients underwent laparoscopic fenestration for macrocystic SC(12-14 cm). Diagnosis was established via magnetic resonance imaging and endoscopic ultrasound, with intra-cystic dosage of tumors markers(ACE and CA19-9) in 2 patients. All patients were symptomatic and operated on 15-60 mo after diagnosis.Radiological evaluation showed constant cyst growth.Patients were informed about this new surgical modality that can avoid pancreatic resection. The mean operative time was 103 min(70-150 min) with one conversion.The post-operative course was marked by a grade A pancreatic fistula in one patient and was uneventful in the other two. The hospital stay was 3, 10, and 18 d, respectively. The diagnosis of macrocystic SC was histologically-confirmed in all cases. At the last followup(13-26 mo), all patients were symptom-free, and radiological evaluation showed complete disappearance of the cyst. Laparoscopic fenestration, as opposed to resection, should be considered for large symptomatic macrocystic SC, thereby avoiding pancreatic resection morbidity and mortality. | Safi Dokmak Béatrice Aussilhou Fanjandrainy Rasoaherinomenjanahary Alain Sauvanet Marie-Pierre Vullierme Vinciane Rebours Philippe Lévy | 2015 | World Journal of Gastroenterology2015，21，22： | 0 |
| 18 | Numerical study of hemodynamic factors in computational fluid dynamic modeling of intracranial artery atherosclerotic stenosis显示文摘Objective To study the role of risk factors associated with hemodynamics in patients with intracranial artery stenosis.Methods Eighteen patients with local stenosis of middle cerebral artery were recruited in this study retrospectively.According to patients’clinical symptoms and magnetic resonance imaging findings,they were | 沈雷 | 2016 | China Medical Abstracts(Internal Medicine)2016，33，2： | 0 |
| 19 | A case of symptomatic epidural gas accumulation due to peptostreptococcus micros infection显示文摘Epidural gas accumulation caused by anaerobic organisms has been reported rarely.Here we describe a case of symptomatic epidural gas associated with anaerobic cellulitis due to Peptostreptococcus micros infection. | Cheng Kun Leong Chan Seng Lam In Fong | 2012 | 镜湖医学2012，12，1： | 0 |
| 20 | Symptomatic and Asymptomatic SARS-CoV-2 Infection and Follow-up of Neutralizing Antibody Levels显示文摘Objective To investigate neutralizing antibody levels in symptomatic and asymptomatic patients with coronavirus disease 2019(COVID-19)at 6 and 10 months after disease onset.Methods Blood samples were collected at three different time points from 27 asymptomatic individuals and 69 symptomatic patients infected with severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).Virus-neutralizing antibody titers against SARS-CoV-2 in both groups were measured and statistically analyzed.Results The symptomatic and asymptomatic groups had higher neutralizing antibodies at 3 months and 1–2 months post polymerase chain reaction confirmation,respectively.However,neutralizing antibodies in both groups dropped significantly to lower levels at 6 months post-PCR confirmation.Conclusion Continued monitoring of symptomatic and asymptomatic individuals with COVID-19 is key to controlling the infection. | CUI Shu Juan ZHANG Yi GAO Wen Jing WANG Xiao Li YANG Peng WANG Quan Yi PANG Xing Huo ZENG Xiao Peng LI Li Ming | 2022 | Biomedical and Environmental Sciences2022，35，12： | 0 |
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