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| 1 | Is diabetic cardiomyopathy a specific entity?显示文摘Diabetes mellitus(DM) is characterised by hyperglycemia, insulin resistance and metabolic dysregulation leading to diastolic and systolic dysfunction in diabetes. In this review, the pathogenetic and pathomorphological changes leading to diastolic and systolic dysfunction in diabetes are discussed. Changes in metabolic signalling pathways, mediators and effectors contribute to the pathogenesis of cardiac dysfunction in DM called diabetic cardiomyopathy(DC). Echocardiographic studies report on the association between DM and the presence of cardiac hypertrophy and myocardial stiffness that lead to diastolic dysfunction. More recently reported echocardiographic studies with more sensitive techniques, such as strain analysis, also observed systolic dysfunction as an early marker of DC. Depression of systolic and diastolic function is continuum and the line of separation is artificial. To conclude, according to current knowledge, DC is expected to be a common single phenotype that is caused by different pathogenetic and pathomorphological changes leading to diastolic and systolic dysfunction in diabetes. | Mitja Letonja Danijel Petrovi | 2014 | World Journal of Cardiology2014，6，1： | 7 |
| 2 | Left ventricular function assessment in cirrhosis:Currentmethods and future directions显示文摘Cirrhotic cardiomyopathy has been defined as a chronic cardiac dysfunction in patients with cirrhosis characterized by impaired contractile responsiveness to stress and/or altered diastolic relaxation with electrophysiological abnormalities in the absence of other known cardiac disease.Non-invasive cardiovascular imaging modalities play a major role in unmasking systolic and diastolic dysfunction in patients with cirrhosis.Echocardiography has been the most commonly used modality for assessing myocardial function in these patients.Conventional echocardiographic indices rely on several assumptions that may limit their applicability in patients with a hyperdynamic circulation.Newer imaging modalities may contribute to a more accurate diagnosis of cardiovascular abnormalities in cirrhotic patients,thereby influencing clinical management.We aimed to review the different non-invasive imaging technologies currently used for assessing left ventricular systolic and diastolic function in cirrhosis,as well as to describe new imaging modalities with potential clinical applicability in the near future. | Francisco Sampaio Joana Pimenta | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 3 | Changes in plasma total bile acid level of patients with essential hyper tension and of spontaneous hypertension rats and the correlation with systolic and diastolic blood pressures显示文摘To examine the hypothesis that plasma bile acid (BA) level is correlated with essential hypertension (EH). Methods: The level of plasma total bile acid (TBA) in 88 patients with EH and in 11 spontaneous hypertension rats (SHR) were measured, and regression analysis of systolic and diastolic blood pressures with plasma TBA was performed. Results: Plasma TBA level in EH patients was significantly higher than that in normotensive subjects (7. 35±3. 38μmol/L vs 4. 94±3. 25 μmol/L, PRO. of ); Plasma TBA level in SHR was significantly higher than that in Wistar--Kyoto (WKY) rats (13. 16±3. 58 μmol/L vs 10. 42±2. 24 μmol/L,P<0. 05); Plasma TBA level in patients with EH was the highest in stage Ⅲ (9. 54±4. 12 μmol/L, n =25), the lowest in stage Ⅰ (5. 76±3. 33 μmol/L, n=33), and middle in stage Ⅱ (7. 32±4. 52 μmol/L, n=30); Plasma TBA level in patients with EH was positively correlated with both systolic (r= 0. 33, P<0. 01 ) and diastolic blood pressure (r=0. 46, P<0.01 ); Plasma TBA level in SHR was positively correlated with both systolic (r=0. 82, P<0. 01 ) and diastolic blood pressures (r=0. 69, P<0. 01). Conclusion: elevated level of plasma TBA in patients with EH and in SHR may participate in the pathogenesis of hypertension. | 张永生 吴平生 刘伊丽 王煊 李欣 | 1998 | Journal of Medical Colleges of PLA(China)1998，13，4： | 6 |
| 4 | Different prognostic association of systolic blood pressure at different time points with postdischarge events in patients hospitalized for decompensated heart failure显示文摘Background The association of systolic blood pressure(SBP) with mortality in heart failure(HF) patients is paradoxical, and the time points of baseline SBP are also different across prior studies. We hypothesized that the levels of SBP at admission and at discharge had different associations with postdischarge events. Methods The study population included patients hospitalized for decompensated HF in the Heart Failure Center of Fuwai Hospital from January 1, 2009 to December 31, 2014. The primary outcome was a composite of cardiovascular(CV) death and heart transplantation. Multivariate Cox proportional-hazards and restricted cubic spline analyses were used to assess the relationships between SBP at different time points and outcomes. Results In total, 2005 patients were included with a median follow-up of 48.4 months. The median age was 59 years, and 69.9% were male. Multivariate Cox analyses showed that compared with SBP < 105 mm Hg, higher SBP at admission was associated with better long-term primary outcome(105–119 mm Hg, HR = 0.764, P = 0.005;120-134 mm Hg, HR = 0.658, P < 0.001;≥ 135 mm Hg, HR = 0.657, P = 0.001). Patients whose discharge SBP was higher than 135 mm Hg had a similar primary outcome as those with SBP < 105 mm Hg(HR = 0.969, P = 0.867), and the results remained unchanged even after adjusting for admission SBP(HR = 1.235, P = 0.291). The results of restricted cubic spline analysis indicated similar associations. Conclusions Lower but not higher SBP at admission is associated with more CV deaths/heart transplantations(a reverse J-shaped curve). In contrast, there is a U-shaped association between discharge SBP and CV mortality/heart transplantation. | You-Nan YAO Rong-Cheng ZHANG Tao AN Qi ZHANG Xin-Ke ZHAO Jian ZHANG | 2019 | Journal of Geriatric Cardiology2019，16，9： | 5 |
| 5 | H型高血压诊断与治疗专家共识显示文摘中国第三次全国死因调查报告表明,脑血管病已成为我国首位死亡原因。同时,我国缺血性脑卒中仍以每年8.7%的速率增长[1]。因此,我国心脑血管病防治的重点是预防脑卒中。
高血压是脑卒中发病最主要的危险因素。在中国,高血压人群中开展的上海老龄人群硝苯地平研究(Shanghai trial of nifedipine in the elderly,STONE)、中国老年收缩期高血压研究(systolic hypertension in China,Syst-CHINA)中发生脑卒中和心肌梗死事件的比值分别为13.0和6.6[2]; | 无 | 2016 | 全科医学临床与教育2016，14，3： | 5 |
| 6 | Non-invasive evaluation of arrhythmic risk in dilated cardiomyopathy:From imaging to electrocardiographic measures显示文摘Malignant ventricular arrhythmias are a major adverse event and worsen the prognosis of patients affected by ischemic and non-ischemic dilated cardiomyopathy.The main parameter currently used to stratify arrhythmic risk and guide decision making towards the implantation of a cardioverter defibrillator is the evaluation of the left ventricular ejection fraction.However,this strategy is characterized by several limitations and consequently additional parameters have been suggested in order to improve arrhythmic risk stratification.The aim of this review is to critically revise the prognostic significance of non-invasive diagnostic tools in order to better stratify the arrhythmic risk prognosis of dilated cardiomyopathy patients. | Massimo Iacoviello Francesco Monitillo | 2014 | World Journal of Cardiology2014，6，7： | 5 |
| 7 | Visit-to-visit Systolic Blood Pressure Variability and Stroke Risk: A Systematic Review and Meta-analysis显示文摘Visit-to-visit variability in systolic blood pressure(SBP)may have an important additional role in increasing the risk of vascular complications,including stroke.We conducted a meta-analysis to assess the relationship between visit-to-visit SBP variability(SBPV)and stroke risk.PubMed,EMBASE,and the Cochrane library databases were searched for cohort studies with data on visit-to-visit SBPV and stroke risk.Studies that reported adjusted relative risks(RRs)with 95%Cis of stroke associated with SBPV were included.Fourteen cohort studies met the inclusion criteria and were included in our meta-analysis.After adjustment for age,sex,and existing vascular risk factors,the analysis showed that the risk of stroke in patients with SBPV was significantly increased compared with patients with a small baseline SBPV[SD(RR=1.20,95%CI=(1.07-1.35),P=0.0005),CV(RR=1.12,95%CI=(1.00-1.26),P=0.008)].In addition,follow-up variations of more than 5 years were associated with a higher risk of stroke than those of less than 5 years[RR=1.08,95%CI=(1.04-1.11)].Visit-to-visit SBPV was associated with an increased risk of stroke,especially in terms of the time of variation.Taken together,SBPV data may be useful as a preventative diagnostic method in the management of stroke. | Han WANG Min LI Shu-hua XIE Ye-tong OYANG Min YIN Bing BAO Zhi-ying CHEN Xiao-ping YIN | 2019 | Current Medical Science2019，39，5： | 4 |
| 8 | Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men显示文摘Osteocalcin is a newly identified type of cytokine secreted by osteoblasts, which has an endocrine function, mediates energy and glycol-lipid metabolism, and is closely related to cardiovascular diseases. In this study, we investigated the value of serum osteocalcin levels in predicting left ventricular systolic dysfunction and cardiac death. A total of 258 patients in the Department of Cardiology were included. Two-dimensional echocardiography was performed in all the subjects. The cardiac death of subjects occurri ng with a media n follow-up of 4.6 years was in formed via phone calls or the electr onic medical records. The serum osteocalcin levels were measured using electrochemiluminescent immunoassay. We found that the median left ventricular ejection fractions (LVEFs) were 62% in men and 63% in women. In the men with a LVEF > 62%, the serum osteocalcin levels were significantly higher than in those with LVEF < 62%(P = 0.042), whereas this differenee was absent in the women. Both the serum osteocalcin (0 = 0.095, P = 0.028) and serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP;p =—0.003, P<0.01) levels remained independently significantly correlated with LVEF in the men but not in the women. Receiver operating characteristic (ROC) analyses of the men revealed that the serum osteocalcin (P = 0.007), serum NT-pro-BNP (P = 0.018) and serum osteocalcin 4- NT-pro-BNP (P< 0.01) levels were all sign ificant in identify ng left ven tricular systolic dysf un ction at baseli ne, but the pairwise comparisons of the three areas under the curves (AUCs) were all non-significant. The men in the lower osteocalcin level group at baseline suffered a greater risk of future cardiac death than those in the higher osteocalcin level group, whereas the result for NT-pro-BNP exhibited the opposite pattern. In conclusion, Iower serum osteocalcin levels in the men could identify left ventricular systolic dysfunction and cardiac death in a manner that was not inferior to high serum NT-pro-BNP levels. | Xue-li Zhang Yun Shen Xiao-jing Ma Zhi-gang Lu Yi-ting Xu Qin Xiong Yu-qian Bao | 2019 | Acta Pharmacologica Sinica2019，40，4： | 4 |
| 9 | 苯磺酸氨氯地平与苯那普利联合治疗老年单纯收缩期高血压的疗效观察显示文摘我国现有60岁及以上老年人占比达15%以上,而高血压等疾病的发病率也随之显著增高[1]。据文献报道,65岁及以上的高血压患者中,单纯收缩期高血压(isolated systolic hypertension,ISH)占比高达80%[2]。老年单纯收缩期高血压在临床上风险较一般高血压更高。为此,ISH患者的降压治疗策略和药物选择。 | 陈国贤 王伟民 谭月霞 | 2016 | 中国现代医药杂志2016，18，3： | 3 |
| 10 | Is Chinese Herbal Medicine Effective for Elderly Isolated Systolic Hypertension? A Systematic Review and Meta-Analysis显示文摘Objective:To study the efficacy of Chinese medicine(CM) on isolated systolic hypertension.Methods:Seven electronic databases were searched for randomized controlled trials(RCTs) published until August 2015.Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies.Results:A total of 24 studies,including 2,096 patients(1,058 patients in the intervention group and 1,038 in the control group),were evaluated in the final analysis.Compared with a conventional therapy used alone,CM as additional intervention was more effective on systolic blood pressure[mean difference(MD)=-0.66,95%confidence interval(CI)=(-0.97,-0.36),P<0.00001]and significantly diminished the pulse pressure[MD=-7.49,Cl=(-12.69,-2.29),P<0.00001].However it showed no additional benefit on diastolic blood pressure[MD=1.16,CI=(0.02,2.29),P=0.87].Adverse events were not explicitly reported in most RCTs.Conclusions:CM might be a promising approach for the elderly with isolated systolic hypertension,while the evidence for CM employed alone was insufficient.Considering the inherent limitations of the included studies,larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future. | CAO Yu LIU Long-tao WU Min | 2017 | Chinese Journal of Integrative Medicine2017，23，4： | 3 |
| 11 | Clinical Significance of Fetal Cerebral and Umbilical Arte-rial Blood Flow Velocity Wave Forms Examination.显示文摘Color Doppler was used to examine the blood flow velocity wave forms of fetal middle cerebral artery (MCA) and umbilical artery (UA) in normal pregnancy (58 cases) pregnancy induced hypertension (PIH) with fetal growth retardation (IUGR) (54 cases) and without IUGR (34 cases). The peak-systolic / diastole ratio (S/D), pulse index (PI) and resistance index (RI) values of MCA and UA were calcu- | Yang Yuying et al. The Affiliated Hospital, Shandong Med Uni, Jinan 250012, | 1995 | Chinese Medical Journal1995，，7： | 3 |
| 12 | 血压管理:向更低目标水平迈进!——来自收缩压干预试验的启示显示文摘2015年11月9日在奥兰多召开的美国心脏协会(American Heart Association,AHA)年度科学大会上,收缩压干预试验(systolic blood pressure intervention trial,SPRINT)研究结果正式公布,其内容同步在线发表在《新英格兰医学杂志》(New England Journal of Medicine)上[1]。 | 刘靖 | 2015 | 中华高血压杂志2015，23，12： | 2 |
| 13 | 踝间血压差研究进展显示文摘踝间血压差(踝间差,the difference of interankle systolic blood pressure)是双下肢踝部收缩压的差值。据统计发现,社区人群中踝间差≥10 mm Hg(1mm Hg=0.133kPa)的检出率为18.5%[1],而在脑卒中患者中踝间差≥7mm Hg的检出率为59.6%。近年来,有越来越多的研究显示踝间差增大是多种疾病的独立危险因素,而且对于心脑血管病、慢性肾脏病以及透析患者的预后具有预测意义。 | 孙麒涵 郭宏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 14 | 利用Hestenes SVD及其修正算法实现阵列超分辨处理显示文摘本文将Hestenes奇异值分解(SVD:SingularValueDecomposition)算法推广到复域,并提出一种可以直接获得有序排列奇异值的修正Hestenes算法,研究了它们分别在线性Systolic阵列处理和SIMD(SingleInstructionMultipleData)阵列处理中的实现原理.作为一个应用实例,我们讨论了通过SVD实现阵列信号超分辨的原理。计算机模拟实验证明了算法的正确性。 | 冯刚 刘泽民 黄振兴 | 1997 | 信号处理1997，13，1： | 2 |
| 15 | Risk factors for sudden cardiac death to determine high risk patients in specific patient populations that may benefit from a wearable defibrillator显示文摘BACKGROUND There is a high risk for sudden cardiac death(SCD) in certain patient groups that would not meet criteria for implantable cardioverter defibrillator(ICD) therapy.In conditions such as hypertrophic cardiomyopathy(HCM) there are clear risk scores that help define patients who are high risk for SCD and would benefit from ICD therapy. There are however many areas of uncertainty such as certain patients post myocardial infarction(MI). These patients are high risk for SCD but there is no clear tool for risk stratifying such patients.AIM To assess risk factors for sudden cardiac death in major cardiac disorders and to help select patients who might benefit from Wearable cardiac defibrillators(WCD).METHODS A literature search was performed looking for risk factors for SCD in patients post-MI, patients with left ventricular systolic dysfunction(LVSD), HCM, long QT syndrome(LQTS). There were 41 studies included and risk factors and the relative risks for SCD were compiled in table form.RESULTS We extracted data on relative risk for SCD of specific variables such as age,gender, ejection fraction. The greatest risk factors for SCD in post MI patients was the presence of diabetes [Hazard ratio(HR) 1.90-3.80], in patient with LVSD was ventricular tachycardia(Relative risk 3.50), in LQTS was a prolonged QTc(HR36.53) and in patients with HCM was LVH greater than 20 mm(HR 3.10). A proportion of patients currently not suitable for ICD might benefit from a WCDCONCLUSION There is a very high risk of SCD post MI, in patients with LVSD, HCM and LQTS even in those who do not meet criteria for ICD implantation. These patients may be candidates for a WCD. The development of more sensitive risk calculators to predict SCD is necessary in these patients to help guide treatment. | Hilal Mohammed Khan Stephen J Leslie | 2019 | World Journal of Cardiology2019，11，3： | 2 |
| 16 | THE INFLUENCE OF ELECTRO-ACUPUNCTURE AT NEIGUAN AND FIVE SHU POINTS OF TWELVE REGULAR MERIDIANS AT DIFFERENT TIME ON SYSTOLIC TIME INTERVAL OF NORMAL YOUNG ADULTS显示文摘The influence of electro-acupuncture at Neiguan (PC 6)and five shu points of twelve regular meridians at different time on systolic time interval (ST I) of normal young adultswere studied with 6×6 Latin square design in this work.In 12 groups according to 12 regular merldlans,the STIs were measured respectively just before and after electro-acupuncture on Neiguan andfive shu points at 00:00,04:00,08:00,12:00,16:00 and 20:00 of a day.It was found thatexcept the PEPI and PEPI/LVETI ratio among Shenmen(HT 7),Shaochong(HT 9)and Neiguan,Guanchong(TE)and Yemen(TE 2)points,the effects of electro-acupuncture at Neiguan pointand five shu points of twelve regular meridians on the indices of STI of normal young adults wereshowing no slgnificant differences.There also was no difference in different sex.But the indices ofSTI were changed when electroacupuncture on the different points of different meridians at differenttime. | Li Lei, Chen Hanping, Xi Yongjiang, Gu JieShanghai University of TCM, Shanghai 200032, China | 1994 | World Journal of Acupuncture-Moxibustion1994，4，1： | 2 |
| 17 | Clinical characteristics of pulmonary hypertension in bronchiectasis显示文摘作为 bronchiectasis 的复杂并发症,肺的高血压(PH ) 与增加的死亡被联系。然而,血液动力学的特征和肺的动脉的高血压的功效(哼) 在有 bronchiectasis 和 PH 的病人的治疗仍然保持未知。有双边的 bronchiectasis 和并发的 PH 的病人在学习被包括。在基线并且在后续期间的耐心的特征,以及幸存,被分析。这观察研究与 51.5 年的吝啬的年龄在 36 个病人被进行(范围, 1774 年) 。走距离的 6 min 是 300.8 搠睯 吗?? | Lan Wang Sen Jiang Jingyun Shi Sugang Gong Qinhua Zhao Rong Jiang Ping Yuan Bigyan Pudasaini Jing He Zhicheng Jing Jinming Liu | 2016 | Frontiers of Medicine2016，10，3： | 1 |
| 18 | 缺血性卒中后1h内的血压和血管再通 | Mattle H.P. Kappeler L. Arnold M. 赵正卿 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，7： | 1 |
| 19 | 利用Virtex器件实现子空间法雷达目标一维像识别显示文摘雷达目标一维像识别是雷达目标识别中的一个重要方向,并且已经发展了多种算法,子空间法是其中一种有效的方法。本文侧重于子空间法中特征子空间的实现研究,介绍了利用FPGA实现算法的基本设计方法,讨论了CORDIC实现原理、数值精度以及利用FPGA实现CORDIC-SVD的方法并将其应用于特征子空间法的实现中,最后提出了实现奇异值分解的Systolic阵列结构。 | 张健 杨万麟 | 2007 | 现代电子技术2007，30，19： | 1 |
| 20 | 收缩压干预试验中诊间血压变异性与心血管事件的关系显示文摘在接受降压治疗的高危高血压患者中观察诊间血压变异性(office blood pressure variability,OBPV)与心血管事件和死亡关系的研究不多。该研究对收缩压干预试验(systolic blood pressure intervention trial,SPRINT)进行事后分析,SPRINT试验将参与者随机分为强化降压组(目标血压〈120mm Hg,1mm Hg=0.133kPa)或者标准降压组(目标血压〈140mm Hg)。 | 陈嘉睿 叶鹏 Chang TI Reboussin DM Chertow GM Cheung AK Cushman WC Kostis WJ Parati G Raj D Riessen E Shapiro B Stergiou GS Townsend RR Tsioufis K Whelton PK Whittle J Wright JT Papademetriou V | 2017 | 中华高血压杂志2017，25，8： | 1 |
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