Is diabetic cardiomyopathy a specific entity?

查看全文 作　　者：Mitja [1]Letonja;Danijel Petrovi[2]

机构地区：[1]Department of Internal Medicine,Genaral Hospital Ptuj;[2]Institute of Histology and Embryology,Medical faculty,University Ljubljana

出　　处：《World Journal of Cardiology》索引2014年第6卷第1期,共6页

摘　　要：Diabetes mellitus(DM) is characterised by hyperglycemia, insulin resistance and metabolic dysregulation leading to diastolic and systolic dysfunction in diabetes. In this review, the pathogenetic and pathomorphological changes leading to diastolic and systolic dysfunction in diabetes are discussed. Changes in metabolic signalling pathways, mediators and effectors contribute to the pathogenesis of cardiac dysfunction in DM called diabetic cardiomyopathy(DC). Echocardiographic studies report on the association between DM and the presence of cardiac hypertrophy and myocardial stiffness that lead to diastolic dysfunction. More recently reported echocardiographic studies with more sensitive techniques, such as strain analysis, also observed systolic dysfunction as an early marker of DC. Depression of systolic and diastolic function is continuum and the line of separation is artificial. To conclude, according to current knowledge, DC is expected to be a common single phenotype that is caused by different pathogenetic and pathomorphological changes leading to diastolic and systolic dysfunction in diabetes. 关键词：Diabetes MELLITUS Diabetic CARDIOMYOPATHY Pathogenesis DIASTOLIC DYSFUNCTION SYSTOLIC dysfuntion Morphological changes Apoptosis

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Is diabetic cardiomyopathy a specific entity?

参考文献(53)

引证文献(8)

耦合文献(5)

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