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| 1 | Nrf2/ARE信号通路及其调控的抗氧化蛋白显示文摘机体在应对活性氧(reactive oxygen species,ROS)损害时形成了一套复杂的氧化应激应答系统,当暴露于ROS时,机体自身能诱导出一系列保护性蛋白,以缓解细胞所受的损害。这一协调反应是由这些保护性基因上游调节区的抗氧化反应元件(antioxidant responsive element,ARE)来调控的。而近年来的研究发现,核因子NF-E2相关因子(nuclear fac-tor erythroid 2-related factor 2,Nrf2)是ARE的激活因子。Nrf2是外源性有毒物质和氧化应激的感受器,在参与细胞抗氧化应激和外源性有毒物质诱导的主要防御机制中发挥重要的作用。Nrf2-ARE通路是迄今为止发现的最为重要的内源性抗氧化应激通路。 | 李航 段惠军 | 2011 | 中国药理学通报2011，27，3： | 72 |
| 2 | 谣言实现的社会机制及对信息的治理显示文摘Rumors are a type of false information, a consequence of an asymmetrical informational structure. This paper focuses on the social mechanisms of rumor fulfilling. Rumors with important contents related to people’s personal interests win acceptance through changing people’s expected payoffs, misleading people to the belief that acceptance of the rumor would beneficially outperform rejection of it. Nevertheless, it is risky to believe rumors; therefore, people make their decision whether to believe a rumor or not by referring to other people’s choices. An analysis was performed first within a game model that incorporated the variables of an individual’s expectancy and other people’s impact to predict whether the individual would accept or reject a rumor. Another analysis followed to further examine the functions of some dynamic mechanisms in rumor fulfilling when group pressure and network effects were introduced. Finally, an exploratory discussion on how to prevent rumors and erase their effects via information management strategies was presented. | 李国武 | 2005 | 社会2005，25，4： | 31 |
| 3 | Keap1-Nrf2-ARE信号通路及其激活剂的研究进展显示文摘Keap1-Nrf2-ARE信号通路是细胞防御氧化应激损伤的最重要机制之一。许多具有解毒、抗氧化防御功能的蛋白质,其转录调控都依赖于Nrf2信号通路的激活。研究表明,Nrf2信号通路已成为氧化应激相关疾病(神经退行性疾病、癌症、心血管系统疾病、代谢和炎症等疾病)预防和治疗的靶点。因此,Nrf2信号通路的激活剂在多种氧化应激诱发的疾病方面都表现出良好的预防及治疗作用,发现及研究Nrf2信号通路的激活剂已越来越受到研究者们的重视。该文概述了Keap1-Nrf2-ARE通路的作用机制,并阐述了Keap1-Nrf2-ARE信号通路小分子激活剂的研究进展。 | 姚娟 吴平安 李芸 李越峰 刘东玲 刘雪枫 | 2019 | 中国药理学通报2019，35，10： | 31 |
| 4 | Keap1-Nrf2信号通路与细胞氧化应激反应相关性研究进展显示文摘来自于外界环境的刺激破坏了机体内的氧化还原平衡,使细胞产生氧化应激。为了应对氧化应激所产生的毒性作用,机体内细胞在进化的过程中产生了一系列相对复杂的机制来应对氧化应激。Keap1-Nrf2信号通路被激活,核转录因子Nrf2入核并激活多种抗氧化基因转录,从而减轻了ROS和亲电性物质所引起的细胞损伤,维持机体内的氧化—抗氧化的生理平衡。本文就氧化应激反应、Keap1-Nrf2通路以及两者之间的相关性研究做一综述。 | 陈光海 刘晓平 | 2016 | 医学理论与实践2016，29，15： | 25 |
| 5 | 论中国西南地区早期佛像显示文摘中国西南地区在东汉晚期至蜀汉前期至蜀汉前期已出现早期佛像,主要见到随葬钱树上的铜或陶质佛像,也有部分崖墓石刻画像中的石佛像,它们很可能代表了中国内地最早阶段的典型佛像。早期佛像在西南地区流行应与本土传统的升仙信仰有关,可能是经由'丝绸之路'传入川西地区后在此区域内传播。 | 罗二虎 | 2005 | 考古2005，，6： | 22 |
| 6 | 阿房宫前殿遗址的考古勘探与发掘显示文摘The Epanggong Palace site of Qin period lies to the south of the Weihe River and to the west of the old Zaohe River course that extends 13 km west of Xi'an City. It stands opposite to the Qin capital Xianyang across the river. From October 2002 to December 2004, the Epanggong Palace Archaeological Team made a prospection on the anterior hall site,covering :350, 000 sq m, and revealed an area of 3, 000 sq m by trial and extensive excavations. The results include a rough understanding of the limits of the hall and the layout of its auxiliary buildings. It can be confirmed that the rammed earth foundations of the hall represents just the anterior hall of that of the Qin Epanggong Palace. What merits special notice is that there are no fire traces on the site of the anterior hall of the Qin Epanggong Palace, which forms a clear contrast to the archaeologically excavated Nos. 1-3 palaces in the Qin capital Xianyang that were destroyed by a great fire. Thus the excavations prove that the historically handed-down belief taking the Qin Epanggong Palace to have been fired by Xiang Yu is actually incorrect. There are no any building remains on the excavated hall foundations, which demonstrate that the anterior hall was not completed and that the Qin Epanggong Palace was destroyed not by fire。 | 李毓芳 孙福喜 王自力 张建锋 | 2005 | 考古学报2005，，2： | 17 |
| 7 | 江苏高淳县薛城新石器时代遗址发掘简报显示文摘The Xuecheng site lies at Xuesi village of Xuecheng township, Gaochun county, Nanjing city, Jiangsu province, on the southern shore of the Shijiu Lake. It was excavated in 1997, which resulted in the revelation of 115 Neolithic tombs and many ash-pits, house-foundations and fireplaces and the discovery of pottery, jade, stone and bone artifacts and quantities of animal remains. The cultural deposits can he divided into the upper, middle and lower layers, which are all simple in cultural content and represent the late, middle and upper phases respectively. The cultural aspect shows strong regional features distinctly different from the contemporary cultures of adjacent areas, which suggests that the remains can he named “Xuecheng cultural type. ” Chronologically, the early phase roughly corresponds to the middle and late Majiahang culture, the middle phase to the second period of Beiyinyangying culture or a little earlier than it, and the late phase to the middle and late Songze culture. | 周裕兴 王志高 张金喜 | 2000 | 考古2000，，5： | 17 |
| 8 | 重庆巫山麦沱古墓群第二次发掘报告显示文摘The first excavation at Maituo, Wushan, which revealed 19 tombs, basically clarified the cultural characteristics of the Han tombs in the cemetery and preliminarily established the periodization criteria for these tombs. Among the 13 tombs uncovered in the present second excavation besides four Han tombs, there are newly discovered burial types that belong to the Warring States, Southern Dynasties and Song. They provided new data for further research into the cultural features of this graveyard in different periods. The achievements in the present excavation consist mainly in the following two aspects,The first is the discovery of three tombs belonging to the late Warring States period. They represent the Chu cultural complex in an area dominated by the Qin State. The second is the revelation of an Eastern Han high-rank tomb in a good condition (M47). The tomb contains over 100 funeral objects, including objects in gold, silver, bronze and lacquer that reflect the tomb owner's wealth, as well as rare treasures of art, such as exquisite glazed pottery tombfigurines of dancers, lamps with toad-shaped stands, and large-sized pottery, tomb guardians, animals, human figures and statues of the Western Queen Mother that are represented in various positions. The unearthed pottery models of buildings, such as those of theatres and watchtowers delicate in workmanship and clear in layout, are valuable to studying Han architecture. These finds provide precious data for systematically studying Han period production technology, culture and art, building style, religion, and burial customs. | 尹检顺 谭远辉 | 2005 | 考古学报2005，，2： | 17 |
| 9 | 德国历史学派与19世纪经济学方法论之争的启示显示文摘In the mid-19th century, out of their dissatisfaction with the neglect of the economic theories about other countries’ experiences in the British classic economics, the economists in the German Historical School worked hard to construct an economic theory that was congruent to the developmental stage in their own country’s culture and history. Their deeply-cherished concern about the reality in a transitional era when Germany was approaching modernization drove them to propose that the living condition of the working class be improved by the power of the state. In the late 80’s of the same century, the Methodenstreit of German Historical School versus the Austrian School broke out, after which the mainstream economics was well on its way in terms of theoretical refinement and scrutiny, whereas the influence from the Historical School gradually subsided. Even so, the lessons from the Historical School are still enlightening to research in contemporary social sciences. This paper describes the unique basics in the theory building of the Historical School; explains the background and meaning of its academic origin, research methodology, and the Methodenstreit; and from there, discusses implications for contemporary social sciences. | 何蓉 | 2005 | 社会2005，25，3： | 15 |
| 10 | 盘龙城商代宫殿基址讨论显示文摘The large-sized rammed-earth building foundations on the Panlongcheng site at Huangpi are remains of early Shang period palace complex. The No. 1 Panlongcheng palace consists of four rooms with wooden-framed walls. The two rooms in the middle each have two doors on the northern and southern sides respectively;while the two end rooms have only southern doors. So the No. 1 palace must have been in the center of the whole building complex. The roof supported by peripheral columns and wooden-framed walls can be reconstructed to be hipped and single- or double- eaved. The hypothesis that the No. 1 palace may have had projecting-eaves columns has not been confirmed. The No. 2 palace is an open hall without peripheral walls and room division; its roof is supported by peripheral columns only. The idea of reconstructing it as a building with pilasters and multiple rooms seems to lack archaeological evidence. The remaining vestiges show that there were side corridors in the two flanks of the main hall of the No. 2 palace. Referring to the Shang period palace material unearthed from the Shang city-site at Yanshi and other localities, it can be inferred that either of the Nos. 1 and 2 palaces must have had an eastern corridor and a western one, and, in addition, the No. 2 palace must have had a southern corridor with a gate house. The Nos. 1--3 palaces of the Panlongcheng site formed three compounds located one behind another, and belonged to the type of court-and-living building complex. Among them the No. 2 palace was the outer court for holding great ceremonies, the No. 1 palace was the inner court for handling daily administrative affairs, and the No. 3 palace was the king and queen's living place. To the southeast of the No. 2 palace remains a group of rammed-earth house-foundations, which must have been left over from another type of palace building, possibly an ancestral temple. The remaining city-walls at Panlongcheng must have belonged to the peripheral city-walls. The palace area is in the northeast of the enclosed area, accounting for 1/4 of the total. If there were enclosing walls around the palace area, they must have been to the east of the northern gate of the peripheral city-walls and to the north of the eastern gate. | 杜金鹏 | 2005 | 考古学报2005，，2： | 14 |
| 11 | 一维链状4-羧基苯氧乙酸桥联钴配位聚合物[Co(p-CPOA)(2,2'-bipy)(H_2O)]_n的合成与晶体结构显示文摘A novel coordination polymer of [Co( p-CPOA)(2,2′-bipy)(H2O)]n ( p-CPOA2-=4-carboxylphenoxyacetate dianion, 2,2′-bipy=2,2′-bipyridine) was synthesized and characterized by elemental analysis, IR and X-ray single crystal diffraction. The title complex crystallizes in monoclinic space group C2/c, with a=1.424 4(3) nm, b=1.316 6(3) nm, c=1.947 7(4) nm, β=104.56(3)°. V=3.535 3(14) nm3, Z=8, R=0.028 5, wR=0.089 1. The cobalt(Ⅱ) ion displays a distorted octahedral coordination geometry, defined by three carboxyl oxygen atoms from different p-CPOA2- groups, two nitrogen atoms from 2,2′-bipyridine ligand and one water molecule. The cobalt atoms are bridged by p-CPOA2- groups, forming a one-dimensional chain structure along a axis. The adjacent Co...Co atoms distance is 0.996 8 nm. A layer supramolecular network is contrsucted by the hydrogen bonds and π-π stacking interactions. CCDC: 220039. | 高山 霍丽华 谷长生 赵辉 赵经贵 | 2005 | 无机化学学报2005，21，5： | 13 |
| 12 | Keap1-Nrf2/ARE信号通路及其在畜禽抗氧化中的研究进展显示文摘正常生理状态下,动物体内自由基的产生和清除处于稳定的动态平衡,但发生氧化应激时,体内自由基产生的量超过自身清除能力,引起氧化系统和抗氧化系统的失衡,造成氧化损伤。而Keap1-Nrf2/ARE信号通路的激活在预防氧化应激引起的细胞和组织损伤、维持氧化还原平衡和蛋白质稳态以及调节炎症方面具有关键作用。Keap1是Nrf2的胞浆抑制蛋白,在正常生理状态下,Nrf2与Keap1结合而发生泛素化和蛋白酶体降解,使细胞核内Nrf2的含量维持在一个相对较低的水平。在氧化应激条件下,Keap1对Nrf2的泛素化和降解的能力减弱,细胞核中Nrf2积聚,Nrf2与抗氧化反应元件(ARE)结合后启动下游一系列保护性基因的表达,使机体从氧化应激状态恢复到正常的生理状态。氧化应激参与多种病理生理变化,对畜禽的生产性能、生长发育、繁殖性能、肉品质等有负面影响,Keap1-Nrf2/ARE信号通路是细胞内最重要的抗氧化应激通路之一,对动物的健康保护极其重要。作者总结了Keap1-Nrf2/ARE信号通路的基本结构和活化机制及其在畜禽抗氧化中的研究进展,阐述了其在提高畜禽的抗氧化、抗炎能力和在肉品质中的重要作用,以期为缓解当前畜禽业中严重的氧化应激和炎症提供理论依据。 | 窦彩霞 王倩 安建勇 乔家运 | 2019 | 中国畜牧兽医2019，46，9： | 12 |
| 13 | Nrf2-ARE信号通路在左乙拉西坦抗癫痫中的作用显示文摘目的探讨Nrf2-ARE信号通路在左乙拉西坦抗癫痫中的作用,以及应用左乙拉西坦对认知功能的影响。方法成年♂SD大鼠36只,250~300 g,随机分为生理盐水对照(control)组、戊四唑(1,5-pentamethylene-1H-tetrazole,PTZ)癫痫模型组、左乙拉西坦(levetiracetam,LEV)对照组以及左乙拉西坦治疗组,每组9只。以Morris水迷宫测试大鼠的空间学习记忆能力;用免疫印迹法测定海马组织中Nrf2、HO-1和NQO1蛋白表达量。结果与癫痫模型组相比,给予左乙拉西坦治疗的癫痫大鼠在Morris水迷宫测试中潜伏期明显缩短(P<0.05),海马Nrf2、HO-1、NQO1蛋白表达均明显增高(P<0.01)。结论左乙拉西坦能够改善癫痫大鼠的认知功能,其机制可能通过Nrf2-ARE通路,使HO-1、NQO1蛋白表达增多,起到抗癫痫的作用。 | 吴可 赵文丽 李月影 邱长雨 施海静 张咏梅 | 2017 | 中国药理学通报2017，33，10： | 12 |
| 14 | 略论西南地区早期平底双耳罐的源流及其族属问题显示文摘The rock-cut tomb and cist burial culture prevailed once in ancient southwest China.There have long been many discrepancies of views on its origin, evolution, periodization and ethnic attribution in academic circles. Based on an analysis of the pottery flat-bottomed amphoras that constitute its major characteristic feature, the present paper points out that these typical vessels were roughly distributed in the upper Minjiang River valley, western Sichuan, eastern Tibet, northwestern Yunnan, southwestern Sichuan, and the areas to the west of the Dianchi Lake and to the east of the Erhai Lake. Most of the amphoras recorded so far are unearthed from rock-cut and cist tombs while a small number from earthen-pit,brick-and-stone and brick-chambered burials. Those found in Yunnan are from earthen-pit and cist tombs. Through a systematic study of their typological classification, periodization and origin, the author comes to the conclusion that the emergence of these vessels resulted from the constant southward migration of nomads belonging to the Di-Qiang ethnic group in northwest China. The starting point of these vessels can be traced to the turn from the Xia to the Shang period. Latter, with the amalgamation of ethnic groups and the formation of a plural national unity in the Han Dynasty, these immigrants gradually changed their way of life from husbandry to settled farming, and in southwest China early-style flat-bottomed amphoras became extinct little by little. Therefore their lower limit was the Eastern Han period. Thus they were out of prevalence in the Eastern Han period. The above-described amphoras fall roughly into five types and further into several subtypes and styles, which represent respective temporal and spatial links of their evolutionary sequence. Their proto-type and similar forms must have originated from the Keshengzhuang Ⅱ, Qijia, Siba, and Kayao cultures in the northwest China. The cultural source and ethnic attribution of early-style flat-bottomed amphoras in the southwest China reflect clearly that from the Bronze Age to the early Iron Age, owing to the collision of civilizations and the acceleration of their development, a migration ware was again brought about in the ethnic history of west China. The southward migration of the Di-Qiang ethnic group from northwest China was an important origin of nationalities and their cultures in ancient southwest China. | 谢崇安 | 2005 | 考古学报2005，，2： | 11 |
| 15 | Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment显示文摘To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group(18 cases) or a denosumab plus vitamin D supplementation group(combination group; 23 cases). We measured serum bone alkaline phosphatase(BAP), tartrate-resistant acid phosphatase(TRACP)-5 b and urinary N-terminal telopeptide of type-I collagen(NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months. We also measured bone mineral density(BMD) of L1–4 lumbar vertebrae(L)-BMD and bilateral hips(H)-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5 b and urinary NTX were significantly suppressed in both groups from 1 week to 12 months(except at 12 months for NTX). In the combination group, TRACP-5 b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months(P < 0.05).BAP was significantly suppressed in both groups at 2–12 months. L-BMD significantly increased at 8 and12 months(8.9%) in the combination group and at 4, 8 and 12 months(6.0%) in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group(3.6%) compared with the denosumab group(1.2%) at 12 months(P < 0.05). Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD(especially at the hips). | Yukio Nakamura Takako Suzuki Mikio Kamimura Kohei Murakami Shota Ikegami Shigeharu Uchiyama Hiroyuki Kato | 2017 | Bone Research2017，5，4： | 11 |
| 16 | 何首乌块根中砷、镉、汞和铅含量的检测及其富集特性显示文摘The contents of As, Cd, Hg and Pb in root tubers of annual and biennial plants of Polygonum multiflorum Thunb. in Jiangsu Province were 0.32, 0.24, 0, 1.25 and 0.20, 0.26, 1.67×10 -4, 1.32 mg·kg -1 respectively, which totally met the standards of GTSIEMPP (WM2—2001). Biology concentration factors (BCF) of Cd is 2.4-2.6, which indicates that the root tuber of P. multiflorum has a strong accumulative action to Cd. While the accumulative action to As, Hg and Pb is not strong, BCF are 0.025-0.015, 0-6.40×10 -4 and 0.06 respectively. | 李正 杭悦宇 周义峰 | 2005 | 植物资源与环境学报2005，14，2： | 9 |
| 17 | 二正丁基二硫代氨基甲酸锌配合物的量子化学研究显示文摘The geometric configurations of binuclear Zinc( complex Zn2[(n-Bu)2NCSS]4 and the ligand Na[(n-Bu)2 NCSS] have been optimized by B3LYP quantum chemical method. The electronic structures have been performed by density functional theory at B3LYP/6-31G* level. The electronic spectrums of the complex and ligand were calculated by ZINDO/S-CIS method. It is indicated from the calculation that: (1) The coordination effect of bridging ligand is bigger than that of chelating one, and the bridging ligands also translate more charge to Zn than the chelating one. (2) The calculated results about electronic spectrums are similarly to experimental measurement, and farther explain that absorption band at λ=267 nm of complex is assigned to two n → π* transitions :one arising from the bridging ligands and the another mainly arising from the chelating ligands;but absorption band at λ=236 nm of complex is assigned to π → π* transition which the electron mainly translates from the bridging ligands to the chelating ligands. (3) By consideration of delocalization and polar effects in coordination, the charge transfer from ligand to metal decreases the π-π and p-π conjugation effects in the chromophore group NCS2 and to increase the energy needed for the π → π* and n → π* transitions, and results in the absorption bands shifting towards the short wavelength direction. | 许旋 方亮 徐志广 陈兆星 钟昀 章伟光 | 2005 | 无机化学学报2005，21，7： | 9 |
| 18 | 贵州省气象信息业务系统的虚拟化实现显示文摘随着气象信息业务系统建设的飞速发展,保障业务系统的安全、可靠、稳定运行成为信息化建设和运维管理的首要工作。通过阐述贵州省气象信息中心基于IT基础架构虚拟化技术,将多个业务系统虚拟集中运行在两台物理服务器上的实例,分析采用虚拟化技术后给简化系统运维管理、降低维护成本、保障业务系统稳定运行等方面带来的显著效益。 | 汪华 黄笞 方斌 | 2012 | 成都信息工程学院学报2012，27，2： | 9 |
| 19 | 配位聚合物{[Zn(CF_3COO)_2(C_5H_5ON)·]H_2O}_n的合成、晶体结构及表征显示文摘new coordination polymer {[Zn(CF3COO)2(C5H5ON)]·H2O}n was synthesized based on the reaction of zinc(Ⅱ) trifluoroacetate and 3-hydroxypyridine(C5H5ON) in methanol medium for the first time. The structure of the coordination polymer was confirmed by IR, 1H NMR, elemental analysis and thermal analysis. The crystal structure of the coordination polymer was also determined by X-ray single crystal diffraction. The crystal belongs to monoclinic system with space group P21/m, and crystallographic data of the coordination polymer are: a= 0.863 1(4) nm, b=0.717 7(3) nm, c=1.116 4(5) nm, α=γ=90°, β=107.542(6)°, V=0.659 4(5) nm3; Dc=2.037 g·cm-3; Z=2; F(000)=400; μ=1.969 mm-1. Zinc(Ⅱ) atom lies at the center of an octahedron formed by the coordination of zinc atom and six O atoms which come from four different trifluoroacetate ions and two different 3-hydroxypyridine molecules where each trifluoroacetate ion and 3-hydroxypyridine are coordinated to two different zinc ions to form coordination polymer. CCDC: 253909. | 马卫兴 高健 钱保华 许兴友 陆路德 杨绪杰 汪信 宋海斌 | 2005 | 无机化学学报2005，21，5： | 8 |
| 20 | 采样系统的提升技术:是与非?显示文摘The lifting technique is now a well recognized tool for H∞ design and analysis of sampleddata systems. However, the efficiency of the method depends on the structure of the problem. The structure of the Ho sensitivity problem is analyzed in this paper. And the constraints on the H∞-optimization problem and on the design parameters in lifting design are also discussed. Under such constraints the resulting performance from the design is generally low. Therefore, the lifting technique can not be recommended as a synthesis tool for the sampled-data systems. An example is also given in the paper. | 王广雄 刘彦文 何朕 王勇莉 | 2005 | 自动化学报2005，31，3： | 8 |
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