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| 1 | Discovery of laryngeal carcinoma by serum proteomic pattern analysis显示文摘Laryngeal carcinoma is the most common malignancy among head and neck tu-mors. The purpose of this study is to find biomarkers for laryngeal carcinoma in patient blood serum using the Surface Enhanced Laser Desorption/Ionization (SELDI) technique. Serum samples from 33 laryngeal carcinoma (12 cases of glottis, 18 of supraglottis and 3 of subglottis) patients and 31 age- and sex-matched healthy people were analyzed by SELDI-TOF on a Pro-teinChip reader, PBSII-C. Protein profiles were generated using WCX2 protein chips. Protein peak clustering and classification analyses were performed utilizing the Biomarker Wizard and Biomarker Pattern software packages, respectively. The results showed that sixteen peaks had significant difference between laryngeal cancer patients and healthy group, eight of which were up-regulated in the patient samples, and the others were down-regulated. Two protein peaks 8153 Da and 2035 Da were automatically chosen for the system training and development of a classification tree. The analysis yielded a correct percentage of 96.9% for patients and 96.7% for control. The results suggest that serum is a useful resource for the detection of specific bio-markers for laryngeal carcinoma. Proteinchip Array System was a useful tool for a high throughput screening of large-sized serum samples to discover potential biomarkers for carci-noma. | XIAO Xueyuan1, ZHAO Xiaodong2, LIU Jiankai3, GUO Fuzheng1, LIU Danhui1 & HE Dacheng1 1. Key Laboratory for Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Universities?Confeder-ated Institute of Proteomics, Beijing 100875, China 2. Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital, Jilin University, Changchun 130031, China 3. Department of Biochemistry, Jilin University, Changchun 130021, China | 2004 | Science China(Life Sciences)2004，47，3： | 22 |
| 2 | 烟雾病免疫相关基因研究显示文摘目的通过分析烟雾(moyamoya)病患者外周血液淋巴细胞和正常人外周血液淋巴细胞免疫相关基因表达的差异,探讨烟雾病的发病机制。方法分别采集烟雾病患者和正常人血液标本各22份,提取烟雾病患者和正常人外周血液淋巴细胞的总RNA,将mRNA逆转录为cDNA,用Cy5和Cy3标记作为探针,与含有492个基因的自身免疫和炎症反应基因芯片进行杂交。以ScanArray4000荧光扫描仪扫描芯片上两种荧光信号,用计算机进行处理和分析。结果烟雾病患者外周血液淋巴细胞和正常人血液淋巴细胞比较,差异表达2倍以上的基因共有32个,其中19个基因表达增加,13个基因表达降低。结论烟雾病发生与患者的免疫相关基因异常有关。 | 陈赞 菅凤增 王伊鹏 何川 凌锋 | 2005 | 中国脑血管病杂志2005，2，5： | 20 |
| 3 | 二维电离室矩阵在调强放疗剂量验证中的应用显示文摘二维电离室矩阵是由电离室规则排列而成的一种新型测量设备,在剂量测量与验证中具有重要应用。笔者介绍德国PTW公司设计生产的二维电离室矩阵2D Array Sev-en29^TM在调强放疗计划剂量验证中应用的内容和方法。 | 王运来 戴相昆 谢耩 | 2008 | 中华放射肿瘤学杂志2008，17，2： | 19 |
| 4 | 基于DSP与FPGA的变流器通用控制平台研究显示文摘提出一种基于DSP和现场可编程门阵列(FPGA)双CPU结构的新型变流器控制系统方案,其中DSP完成变流器控制策略的实现,主要包括:最大功率点跟踪、电压电流双闭环控制、低电压穿越控制、通信功能;FPGA完成三相锁相环控制、AD芯片采样控制、SVPWM波形控制、逻辑输出控制以及各类故障信号检测与停机保护功能,并采用了基于WIFI模块的风电故障信息传输系统。以双馈风电变流器为模型,设计了双馈风力发电变流器系统,完成了两电平与三电平SVPWM控制算法的FPGA实现。最后在自主研发的1.5 MW,2 MW双馈式变流器样机与光伏逆变器样机上进行了大量实验和长期的现场试运行,验证了控制系统平台的可行性与实用性。 | 郭巍 肖遥 孙永佳 | 2014 | 电气传动2014，44，2： | 14 |
| 5 | 基于PCR array技术探讨脾虚痰浊证大鼠肝脏脂蛋白和胆固醇代谢信号通路相关基因mRNA表达的变化显示文摘目的:利用PCR array技术观测脾虚痰浊证大鼠肝脏脂蛋白和胆固醇代谢信号通路相关基因mRNA表达。方法:SPF级健康雄性SD大鼠20只,随机分为空白对照组、脾虚痰浊证组。脾虚痰浊证组采用劳倦过度加饮食不节结合高脂饲料喂饲造模。使用间苯三酚法测定D-木糖排泄率,全自动生化分析仪检测血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清淀粉酶(AMY)水平,HE染色观察肝脏形态变化,提取各组大鼠肝脏总RNA,应用脂蛋白和胆固醇代谢信号通路PCR芯片检测脾虚痰浊证大鼠肝脏脂蛋白和胆固醇代谢信号通路相关基因mRNA表达。结果:与空白对照组相比,脾虚痰浊证大鼠血清HDL-C水平显著降低,TC和LDL-C水平显著升高,肝细胞形成大量脂质沉积。PCR array技术分析发现:与空白对照组相比,脾虚痰浊证大鼠上调≥2倍的基因8个,占10%,如Scarf1、Apol2、Abcg1、Apo A1、Acca2、RGD1564999、Il4;下调≥2倍的基因55个,占65%,如Cxcl16、Ldlr、Vldlr、Lrpap1、Ankra2、Apoa4、Cdh13、Colec12等,上述上调或者下调的基因,涉及脂蛋白信号通路的LDL受体、LDL受体相关蛋白、LDL相关蛋白及HDL相关基因;胆固醇转运途径的胆固醇转运、胆固醇流出以及胆固醇逆向转运相关基因;以及胆固醇代谢途径的胆固醇吸收、分解代谢、胆固醇的平衡及生物合成等相关基因。结论:脾虚运化功能失常引起血清胆固醇水平异常及肝脏脂质沉积,可能与调控肝脏的脂蛋白信号通路、胆固醇运输途径以及胆固醇代谢途径基因表达改变有关。 | 王英 贾连群 宋囡 曹媛 曹慧敏 刘晶晶 杨关林 | 2016 | 辽宁中医杂志2016，43，1： | 13 |
| 6 | Array多焦点人工晶状体的初步观察显示文摘目的 初步评估 Array多焦点人工晶状体的有效性。方法 从我院住院的白内障患者中选择合适的病例 ,男 4例 4眼 ,女 6例 7眼 ,行标准超声乳化白内障摘出术联合Array人工晶状体植入术 ,观察患者术后的远、近视力 ,角膜曲率 ,及视觉症状。结果 术后最好视力平均值 :非矫正远视力为 0 .8,最佳矫正远视力为 0 .9,非矫正近视力为 0 .5 ,用视远的矫正度数矫正的近视力为 0 .6 ,最佳矫正近视力为 0 .9。角膜散光术前及术后均小于1.5 D。1例 (9.1% )患者夜间有眩光。结论 Array人工晶状体可以同时提供良好的远视力和近视力 。 | 林振德 冯波 刘奕志 程冰 邹玉平 | 2001 | 眼科新进展2001，21，1： | 13 |
| 7 | 脾虚模型大鼠能量代谢相关性基因研究显示文摘目的:研究脾气虚与脾阳虚大鼠模型能量代谢相关性基因的差异表达,探讨脾气虚与脾阳虚中医证候的生物学基础。方法:将24只大鼠随机分为正常组(8只)、脾气虚组(8只)、脾阳虚组(8只),采用PCR array法测定脾气虚与脾阳虚模型小肠组织能量代谢相关基因的表达水平。结果:脾气虚、脾阳虚模型共性表达下调的能量代谢相关基因包括:神经肽Y、生长抑素、血管活性肠肽;生长抑素在脾气虚模型下调表达尤为显著;神经肽Y在脾阳虚模型下调表达尤为显著。结论:脾气虚与脾阳虚模型能量代谢相关基因的表达与中医脾虚证候密切相关,为进一步阐释脾气虚与脾阳虚模型中医证候的生物学基础提供研究思路。 | 刘继东 苗嘉芮 李宁 曲怡 贾连群 张立德 | 2015 | 中华中医药杂志2015，30，9： | 12 |
| 8 | Numerical study on scanning radiation acoustic field in formations generated from a borehole显示文摘Numerical study on scanning radiation acoustic field in formations generated by linear phased array transmitters in a fluid-filled borehole is carried out using a real axis integration (RAI) method. The main lobe width of the acoustic beams and the incident angle on the borehole wall can be controlled by means of adjusting parameters, such as the element number and the delay time between the neighboring array elements of linear phased array transmitter. The steered angle of longitudinal waves generated in the formation satisfies the Snell’s law for plane waves when the incident angle on the borehole wall is less than the first critical angle. When the lobe width of the acoustic beams is narrow and the steered angle is less than the first critical angle, the acoustic field in the formation can be approximately calculated given that the linear phased array is put in the formation without borehole. The technique of scanning radiation acoustic field can be applied to enhancing investigation resolution and signal-to-noise ratio in crosswell seismic survey and borehole acoustic reflection imaging. | CHE Xiaohua1, ZHANG Hailan1, QIAO Wenxiao2 & JU Xiaodong2 1. Institute of Acoustics, Chinese Academy of Sciences, Beijing 100080, China 2. Faculty of Natural Resources & Information Technology, University of Petroleum, Beijing 102249, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，2： | 11 |
| 9 | High-resolution crustal velocity imaging using ambient noise recordings from a high-density seismic array:An example from the Shangrao section of the Xinjiang basin,China显示文摘A profile of shallow crustal velocity structure(1–2 km) may greatly enhance interpretation of the sedimentary environment and shallow tectonic deformation.Recent advances in surface wave tomography, using ambient noise data recorded with high-density seismic arrays, have improved the understanding of regional crustal structure. As the interest in detailed shallow crustal structure imaging has increased, dense seismic array methods have become increasingly efficient. This study used a high-density seismic array deployed in the Xinjiang basin in southeastern China, to record seismic data, which was then processed with the ambient noise tomography method. The high-density seismic array contained 203 short-period seismometers, spaced at short intervals(~ 400 m). The array collected continuous records of ambient noise for 32 days. Data preprocessing,cross correlation calculation, and Rayleigh surface wave phase-velocity dispersion curve extraction, yielded more than 16,000 Rayleigh surface wave phase-velocity dispersion curves, which were then analyzed using the direct-inversion method. Checkerboard tests indicate that the shear wave velocity is recovered in the study area, at depths of 0–1.4 km,with a lateral image resolution of ~ 400 m. Model test results show that the seismic array effectively images a 50 m thick slab at a depth of 0–300 m, a 150 m thick anomalous body at a depth of 300–600 m, and a 400 m thick anomalous body at a depth of 0.6–1.4 km. The shear wave velocity profile reveals features very similar to those detected by a deep seismic reflection profile across the study area. This demonstrates that analysis of shallow crustal velocity structure provides high-resolution imaging of crustal features.Thus, ambient noise tomography with a high-density seismic array may play an important role in imaging shallow crustal structure. | Gaochun Wang Xiaobo Tian Lianglei Guo Jiayong Yan Qingtian Lyu | 2018 | Earthquake Science2018，31，5： | 9 |
| 10 | Research of optical rainfall sensor based on CCD linear array显示文摘Rainfall monitoring is one of the most important meteorological observation elements for the disaster weather. The maintenance of current tipping bucket rain gauge and weighing type rain gauge is a critical issue. The optical rainfall sensor based on CCD linear array is mainly studied in this paper. Because of the maintenance-free time and good adaptability,it can be widely used in the automatic rainfall monitoring in severe environment and have a good perspective in using. | YANG Bifeng LIU Yuyan LU Ying WU Shangqian | 2015 | Instrumentation2015，2，3： | 9 |
| 11 | Experimental characteristics of a two-electrode plasma synthetic jet actuator array in serial显示文摘Plasma Synthetic Jet(PSJ) actuators have shown wide and promising application prospects in high-speed flow control, due to their advantages including high exhaust speed, wide frequency band, rapid response, and non-moving components. Although previous studies on PSJ actuators are abundant, most of them have focused on the performance of a single actuator. However, in practice, an actuator array is very necessary for large-scale aerodynamic actuation on account of the small affected area of a single PSJ. In this paper, the characteristics of a twoelectrode plasma synthetic jet actuator array in serial are investigated experimentally. Compared to a parallel actuator array, the serial actuator array requires simpler power supply design and is much easier to realize. High-speed photography of the discharge evolution, voltage-current measurement, and shadowgraphy visualization are used in the investigation. Experimental results show that, for the serial actuator array, weak discharges happen firstly between energized and suspending electrodes, and then a strong pulse arc discharge is triggered. The breakdown voltage in serial is irrelevant to such factors as the number of actuators, the maximum or minimum gap in serial,the connection sequence, etc. It is mainly determined by the sum of gaps. For serial actuators with the same anode-to-cathode spacing, the energy deposition is the same, and the jet is synchronous and similar. Because of the entrainment and merging of adjacent jet vortices, the jet front speed of an aligned synchronous jet array increases as the orifice distance decreases. To achieve the highest jet front velocity, the orifice of the actuator has an optimal diameter. | Yan ZHOU Zhixun XIA Zhenbing LUO Lin WANG Xiong DENG | 2018 | Chinese Journal of Aeronautics2018，31，12： | 9 |
| 12 | Joint calibration algorithm for gain-phase and mutual coupling errors in uniform linear array显示文摘The effect of gain-phase perturbations and mutual coupling significantly degrades the performance of digital array radar(DAR). This paper investigates array calibration problems in the scenario where the true locations of auxiliary sources deviate from nominal values but the angle intervals are known. A practical algorithm is proposed to jointly calibrate gain-phase errors and mutual coupling errors. Firstly, a simplified model of the distortion matrix is developed based on its special structure in uniform linear array(ULA). Then the model is employed to derive the precise locations of the auxiliary sources by one-dimension search. Finally, the least-squares estimation of the distortion matrix is obtained. The algorithm has the potential of achieving considerable improvement in calibration accuracy due to the reduction of unknown parameters. In addition,the algorithm is feasible for practical applications, since it requires only one auxiliary source with the help of rotation platforms. Simulation results demonstrate the validity, robustness and high performance of the proposed algorithm. Experiments were carried out using an S-band DAR test-bed.The results of measured data show that the proposed algorithm is practical and effective in application. | Li Weixing Lin Jianzhi Zhang Yue Chen Zengping | 2016 | Chinese Journal of Aeronautics2016，29，4： | 9 |
| 13 | Analysis of Pulse Signals Based on Array Pulse Volume显示文摘Objective: To collect and analyze multi-dimensional pulse diagram features with the array sensor of a pressure profile system(PPS) and study the characteristic parameters of the new multi-dimensional pulse diagram by pulse diagram analysis technology. Methods: The pulse signals at the Guan position of left wrist were acquired from 105 volunteers at the Shanghai University of Traditional Chinese Medicine. We obtained the pulse data using an array sensor with 3×4 channels. Three dimensional pulse diagrams were constructed for the validated pulse data, and the array pulse volume(APV) parameter was computed by a linear interpolation algorithm. The APV differences among normal pulse(NP), wiry pulse(WP) and slippery pulse(SP) were analyzed using one-way analysis of variance. The coefficients of variation(CV) were calculated for WP, SP and NP. Results: The APV difference between WP and NP in the 105 volunteers was statistically significant(6.26±0.28 vs. 6.04±0.36, P=0.048), as well as the difference between WP and SP(6.26±0.28 vs. 6.07±0.46, P=0.049). However, no statistically significant difference was found between NP and SP(P=0.75). WP showed a similar CV(4.47%) to those of NP(5.96%) and SP(7.58%). Conclusion: The new parameter APV could differentiate between NP or SP and WP. Accordingly, APV could be considered an useful parameter for the analysis of array pulse diagrams in Chinese medicine. | CUI Ji TU Li-ping ZHANG Jian-feng ZHANG Shao-liang ZHANG Zhi-feng XU Jia-tuo | 2019 | Chinese Journal of Integrative Medicine2019，25，2： | 8 |
| 14 | Hybrid Particle Swarm Optimization Algorithm Based on Entropy Theory for Solving DAR Scheduling Problem显示文摘An efficient task-scheduling algorithm in the Digital Array Radar(DAR) is essential to ensure that it can handle a large number of requested tasks simultaneously. As a solution to this problem, in this paper, we propose an optimization model for scheduling DAR tasks using a hybrid approach. The optimization model considers the internal task structure and the DAR task-scheduling characteristic. The hybrid approach integrates a particle swarm optimization algorithm with a genetic algorithm and a heuristic task-interleaving algorithm. We introduce the chaos theory to optimize initialized particles and use entropy theory to indicate the diversity of particles and adaptively adjust the inertia weight, the crossover probability, and the mutation probability. Then, we improve both the efficiency and global exploration ability of the hybrid algorithm. In the framework of the swarm exploration algorithm, we include a heuristic task-interleaving scheduling algorithm, which not only utilizes the wait interval to transmit or receive subtasks, but also overlaps the receive intervals of different tasks. In a large-scale simulation,we demonstrate that the proposed algorithm is more robust and effective than existing algorithms. | Haowei Zhang Junwei Xie Jiaang Ge Junpeng Shi Zhaojian Zhang | 2019 | Tsinghua Science and Technology2019，24，3： | 8 |
| 15 | 基于PCR array技术探讨化瘀祛痰方对高脂血症大鼠肝脏脂质代谢信号通路相关基因mRNA表达的影响显示文摘目的采用PCR array技术探讨化瘀祛痰方对高脂血症大鼠肝脏脂质代谢信号通路相关基因mRNA表达的影响,以初步揭示化瘀祛痰方对高脂血症大鼠肝脏脂质代谢的干预作用。方法 24只健康雄性SD大鼠随机分为正常组、高脂血症组、化瘀祛痰组。高脂血症组、化瘀祛痰组予高脂饲料喂饲30天后,化瘀祛痰组予化瘀祛痰中药汤剂灌胃,正常组、高脂血症组给予等体积的生理盐水灌胃。30天后,全自动生化分析仪检测各组大鼠血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量,HE染色观察肝脏形态变化,油红O染色观察肝脏脂质沉积,PCR array技术检测各组大鼠肝脏脂质代谢信号通路相关基因mRNA表达。结果与正常组相比,高脂血症组血清中TC、TG、LDL-C水平显著升高(P<0.01),HDL-C水平显著降低(P<0.01),肝细胞形成大量脂质沉积,胞浆内多出现脂肪空泡;与高脂血症组相比,化瘀祛痰组血清中TC、TG、LDL-C水平显著降低(P<0.01),HDL-C水平显著升高(P<0.05),肝脏脂滴减少。PCR array显示:化瘀祛痰组发生差异改变的基因为Abca1、Apoe、cel、Cyp39a1、Cyp46a1、Cyp7a1、Hmgcr、Ldlr、snx17。结论化瘀祛痰方可能通过调控Abca1、Apoe、cel、Cyp39a1、Cyp46a1、Cyp7a1、Hmgcr、Ldlr、snx17基因,影响胆固醇代谢,发挥其对高脂血症大鼠肝脏脂质代谢的干预作用。 | 陈阳 张妮 贾连群 | 2016 | 时珍国医国药2016，27，4： | 8 |
| 16 | Deep ultraviolet light-emitting diodes based on a well-ordered AlGaN nanorod array显示文摘The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs fabricated by the nanosphere lithography and dry-etching technique. Nanorod DUV LED devices with good electrical properties are successfully realized. Compared to planar DUV LEDs, nanorod DUV LEDs present>2.5 times improvement in light output power and external quantum efficiency. The internal quantum efficiency of nanorod LEDs increases by 1.2 times due to the transformation of carriers from the exciton to the free electron–hole, possibly driven by the interface state effect of the nanorod sidewall surface. In addition, the nanorod array significantly facilitates photons escaping from the interior of LEDs along the vertical direction, contributing to improved light extraction efficiency. A three-dimensional finite-different time-domain simulation is performed to analyze further in detail the TE-and TM-polarized photon extraction mechanisms of the nanostructure. Our results demonstrate the nanorod structure is a good candidate for high-efficiency DUV emitters. | LIANG ZHANG YANAN GUO JIANCHANG YAN QINGQING WU YI LU ZHUOHUI WU WEN GU XUECHENG WEI JUNXI WANG JINMIN LI | 2019 | Photonics Research2019，7，9： | 8 |
| 17 | Neural Network and GBSM Based Time-Varying and Stochastic Channel Modeling for 5G Millimeter Wave Communications显示文摘In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN models are developed for modeling of path loss together with shadow fading(SF)and joint small scale channel parameters.The NN models can predict path loss plus SF and small scale channel parameters accurately compared with measurement at 26 GHz performed in an outdoor microcell.The time-varying path loss and small scale channel parameters generated by the NN models are proposed to replace the empirical path loss and channel parameter random numbers in GBSM-based framework to playback the measured channel and match with its environment.Moreover,the sparse feature of clusters,delay and angular spread,channel capacity are investigated by a virtual array measurement at 28 GHz in a large waiting hall. | Xiongwen Zhao Fei Du Suiyan Geng Ningyao Sun Yu Zhang Zihao Fu Guangjian Wang | 2019 | China Communications2019，16，6： | 7 |
| 18 | Ultrasound Imaging of Pipeline Crack Based on Composite Transducer Array显示文摘Cracks, especially small cracks are di cult to be detected in oil and gas transportation pipelines buried underground or covered with layers of material by using the traditional ultrasonic inspection techniques. Therefore, a new com?posite ultrasonic transducer array with three acoustic beam incidence modes is developed. The space model of the array is also established to obtain the defect reflection point location. And the crack ultrasound image is thus formed through a series of small cubical elements expanded around the point locations by using the projection of binariza?tion values extracted from the received ultrasonic echo signals. Laboratory experiments are performed on a pipeline sample with di erent types of cracks to verify the e ectiveness and performance of the proposed technique. From the image, the presence of small cracks can be clearly observed, in addition to the sizes and orientations of the cracks. The proposed technique can not only inspect common flaws, but also detect cracks with various orientations, which is helpful for defect evaluation in pipeline testing. | Shou-Peng Song Ying-Jie Ni | 2018 | Chinese Journal of Mechanical Engineering2018，31，5： | 7 |
| 19 | One-step synthesis of Fe-Ni hydroxide nanosheets derived from bimetallic foam for efficient electrocatalytic oxygen evolution and overall water splitting显示文摘The research of superior water oxidation electrodes is essential for the green energy in the form of hydrogen by way of electrolytic water splitting, and still remains challenging. Based upon dealloying foam, Fe-Ni hydroxide nanosheets network structure is designed on the surface of Fe-Ni alloy foam. The ratio of Ni/Fe elements was adjusted to realize the optimal catalytic activities for oxygen evolution reaction(OER) and hydrogen evolution reaction(HER). The obtained electrode of Fe-Ni hydroxide nanosheets/Fe-Ni alloy foam-60% Fe(FN LDH/FNF-60, 60 is the percentage of Fe content) possess low overpotential of 261 mV to reach 10 mA/cm^2, small Tafel slope(85.5 mV/dec), and superior long-term stability(remaining 10 mA/cm^2 for over 14 h without attenuation) toward OER in 1.0 mol/L KOH.Moreover, an alkaline water electrolyzer is constructed with the FN LDH/FNF-60 as anode and Ni(OH)_2/Fe-Ni alloy foam-25% Fe(Ni(OH)_2/FNF-25) as cathode, which displays superior electrolytic performance(affording 10 mA/cm^2 at 1.62 V) and lasting durability. | Lili Zeng Linjing Yang Jia Lu Jin Jia Jiayuan Yu Yunqie Deng Mingfei Shao Weijia Zhou | 2018 | Chinese Chemical Letters2018，29，12： | 7 |
| 20 | HER2在结直肠癌中的表达及意义显示文摘目的研究HER2在结直肠癌的表达及意义。方法应用pathway array analysis方法分析了56例结直肠癌肿瘤组织及癌旁正常组织中HER2的表达。结果在56例结直肠癌患者中共发现HER2阳性表达35例,21例正常黏膜组织中HER2过表达,其中16例结直肠癌患者有淋巴结转移。结论 HER2的表达与结直肠癌的发生发展相关,检测HER2的表达可作为判断结直肠癌的生物学行为和预后的重要指标。 | 张凯 王中义 David Zhang 李春 生李红 刘铜军 | 2010 | 中国老年学杂志2010，30，10： | 7 |
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