Alteration of mitochondrial function in adult rat offspring of malnourished dams

查看全文 作　　者：Brigitte [1]Reusens;Nicolas [1]Theys;Claude [1]Remacle

机构地区：[1]Laboratory of Cell Biology,Institute of Life Science,Université Catholique de Louvain,1348 Louvain-la-Neuve,Belgium

出　　处：《World Journal of Diabetes》索引2011年第2卷第9期,共9页

基　　金：Supported by the European Commission (FOOD-CT-2005007036);the Parthenon Trust (London,UK);the Belgian Fonds National de la Recherche Scientifique;the Belgian Fonds pour la Recherche dans l’Industrie et l’Agriculture 摘　　要：Under-nutrition as well as over-nutrition during pregnancy has been associated with the development of adult diseases such as diabetes and obesity.Both epigenetic modifications and programming of the mitochondrial function have been recently proposed to explain how altered intrauterine metabolic environment may produce such a phenotype.This review aims to report data reported in several animal models of fetal malnutrition due to maternal low protein or low calorie diet,high fat diet as well as reduction in placental blood flow.We focus our overview on the β cell.We highlight that,notwithstanding early nutritional events,mitochondrial dysfunctions resulting from different alteration by diet or gender are programmed.This may explain the higher propensity to develop obesity and diabetes in later life. 关键词：FETAL programming β cells Mitochondria MATERNAL MALNUTRITION Rats

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Alteration of mitochondrial function in adult rat offspring of malnourished dams

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