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Indocyanine green clearance test and model for end-stage liver disease score of patients with liver cirrhosis

查看全文 作　　者：Sheng, Qin-[1]Song;Lang, [1]Ren;He, [1]Qiang;Yang, Yong-[1]Jiu;Zhao, De-[1]Fang;Chen, Da-[1]Zhi 高影响力作者 机构地区：[1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Hepatobiliary & Pancreatosplen Surg, Beijing 100020, Peoples R China高影响力机构 出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2009年第8卷第1期,共4页高影响力期刊 摘　　要：BACKGROUND:The indocyanine green(ICG)clearance test(clearance rate(K)and retention rate at 15 minutes (R15))is a sensitive indicator to evaluate liver function. The model for end-stage liver disease(MELD)score has emerged as a useful tool for estimating the mortality of patients awaiting liver transplantation and has recently been validated on patients with liver diseases of various etiologies and severity.In this study,we investigated the correlation between the ICG clearance test and MELD score of patients with liver cirrhosis. METHODS:From June 2007 to March 2008,52 patients with liver cirrhosis admitted to our center were classified into Child-Pugh class A(8 patients),B(14)and C(30).The ICG clearance test(K value and R15)was performed by ICG pulse spectrophotometry(DDG-3300K),and the MELD scores of patients were calculated. RESULTS:As the Child-Pugh classification of liver function gradually deteriorated,the K value decreased, while R15 and MELD score increased.There were significant statistical differences in K value,R15 and MELD score in patients with different Child-Pugh classifications. Significant correlations were found between the parameters of the ICG clearance test(K value and R15)and MELD score.A negative correlation was observed between K value and MELD score(r=-0.892,P<0.05),while a positive correlation was observed between R15 and MELD score(r=0.804,P<0.05).CONCLUSIONS:The ICG clearance test and MELD score are good parameters for evaluating liver function.Moreover, K value and R15 have significant correlations with MELD score,especially the K value,which may be a convenient and appropriate indicator to evaluate liver function of patients with liver cirrhosis. 关 键 词：LIVER function tests indocyanine green model for END-STAGE LIVER DISEASE SPECTROPHOTOMETRY
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