Zinc-prolinamide complex catalyzed direct asymmetric aldol reactions in the presence of water

查看全文 作　　者：LU ZhiJin1,MEI HaiBo1,ZHANG GuangQian1,HAN JianLin1* & PAN Yi1,2* 1School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China 2State Key Laboratory of Coordination Chemistry;Nanjing University,Nanjing 210093,China

出　　处：《Science China Chemistry》索引2010年第53卷第11期,共6页

基　　金：the National Natural Science Foundation of China (20772056);Jiangsu 333 Program (for Pan) for the generous financial support;The research funds for Pan from the Qing-Lan Program of Jiangsu Province;the Kua-Shi-Ji Program of the Education Ministry of China 摘　　要：An efficient direct asymmetric aldol reaction with zinc triflate and prolinamides as combined catalysts is reported.A series of chiral prolinamides have been designed and used in the direct aldol reaction resulting in the desired products with excellent yields(up to 94% yield) and high enantioselectivities(up to 96% ee).Water was found to play a significant role in the formation of the aldol products,which suggests a new strategy in the design of new organic catalysts. 关键词：PROLINAMIDE LEWIS acid AQUEOUS media ALDOL reaction zinc

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Zinc-prolinamide complex catalyzed direct asymmetric aldol reactions in the presence of water

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