Expression and regulation of metalloproteinases-2,-9 and tissue inhibitors of metallo-proteinases in rat corpus luteum

查看全文 作　　者：YU [1,2]Xiaoguang;LI [1]Qinglei;WANG [1]Hongmei;LUO [1]Wenxiang;SHAO [1]Longjiang;Nl [2]Jiang;ZHU [1]Cheng

机构地区：[1]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100080,China;[2]Laboratory of Reproductive Endocrinology,Harbin Medical University,Harbin 150001,China

出　　处：《Chinese Science Bulletin》索引2002年第47卷第12期,共4页

基　　金：This work was supported by the '95' National 'Pan-Deng Project' (Grant No. 970211019-3);the National Natural Science Foundation of China (Grant No. 39970106). 摘　　要：The expression and regulation of metallopro-teinases-2, -9 (MMP-2, -9) and their tissue inhibitors TIMP-1, -2, -3 mRNA were studied in this experiment. In the PMSG-hCG primed pseudopregnant rat, MMP-2, -9 mRNA levels were the highest at Day 1, decreased from Day 4, and reached the minimal level at Day 8, then increased at Day 14; no significant changes were observed in TIMP-2 mRNA expression from Day 1 to Day 14; TIMP-3 mRNA expression was the lowest at Day 1, increased from Day 4, reached the maximal level at Day 8, and persisted to Day 14. TNF-α could significantly increase the expression of MMP-2, -9 and TIMP-1 mRNA in the in vitro perfused pseudopregnant CL, and decrease the expression of TIMP-3 mRNA, but had no effect on TIMP-2 mRNA expression. The results indicate that MMP-2, -9 and TIMP-1, -2, -3 might be involved in the regulation of CL function and maintenance of CL structure via their coordinated gene expression. TNF-a could inhibit luteal regression via increasing MMP-2, -9 and TIMP-1 mRNA 关键词：matrix METALLOPROTEINASES tissue INHIBITORS of metallo-proteinases mRNA CORPUS luteum OVARY perfusion.

相关文献

参考文献（6）
引证文献（0）
耦合文献（2）

参考文献(6)

耦合文献(2)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Expression and regulation of metalloproteinases-2,-9 and tissue inhibitors of metallo-proteinases in rat corpus luteum

参考文献(6)

耦合文献(2)

用户提示