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Risk factors to predict severe postoperative pancreatic fistula following gastrectomy for gastric cancer

查看全文 作　　者：Shuhei [1]Komatsu;Daisuke [1]Ichikawa;Kingo [1]Kashimoto;Takeshi [1]Kubota;Kazuma [1]Okamoto;Hirotaka [1]Konishi;Atsushi [1]Shiozaki;Hitoshi [1]Fujiwara;Eigo [1]Otsuji 高影响力作者 机构地区：[1]Division of Digestive Surgery,Department of Surgery,Kyoto Prefectural University of Medicine高影响力机构 出　　处：《World Journal of Gastroenterology》索引2013年第19卷第46期,共7页高影响力期刊 摘　　要：AIM:To allow the identification of high-risk postoperative pancreatic fistula(POPF)patients with special reference to the International Study Group on Pancreatic Fistula(ISGPF)classification.METHODS:Between 1997 and 2010,1341 consecutive patients underwent gastrectomy for gastric cancer at the Department of Digestive Surgery,Kyoto Prefectural University of Medicine,Japan.Based on the preoperative diagnosis,total or distal gastrectomy and sufficient lymphadenectomy was performed,mainly according to the Japanese guidelines for the treatment of gastric cancer.Of these,35 patients(2.6%)were diagnosed with Grade B or C POPF according to the ISGPF classification and were treated intensively.The hospital records of these patients were reviewed retrospectively.RESULTS:Of 35 patients with severe POPF,17(49%)and 18(51%)patients were classified as Grade B and C POPF,respectively.From several clinical factors,the severity of POPF according to the ISGPF classification was significantly correlated with the duration of intensive POPF treatments(P=0.035).Regarding the clinical factors to distinguish extremely severe POPF,older patients(P=0.035,65 years≤vs<65 years old)and those with lower lymphocyte counts at the diagnosis of POPF(P=0.007,<1400/mm3vs 1400/mm3≤)were significantly correlated with Grade C POPF,and a low lymphocyte count was an independent risk factor by multivariate analysis[P=0.045,OR=10.45(95%CI:1.050-104.1)].CONCLUSION:Caution and intensive care are required for older POPF patients and those with lower lymphocyte counts at the diagnosis of POPF. 关 键 词：PANCREATIC FISTULA International Study Group on PANCREATIC FISTULA classification GASTRIC cancer Gas-trectomy COMPLICATION
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