^(131)I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma

查看全文 作　　者：Qing [1]He;Wu-Sheng [2]Lu;Yang [3]Liu;Yong-Song [1]Guan;An-Ren [4]Kuang

机构地区：[1]Oncology Department,West China Hospital of Sichuan University;[2]Department of Vascular Surgery,West China Hospital of Sichuan University;[3]Department of Psychiatry,West China Hospital of Sichuan University;[4]Department of Nuclear Medicine,West China Hospital of Sichuan University

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第47期,共7页

摘　　要：AIM:To investigate the safety and effectiveness of combined131I-metuximab and transcatheter arterial chemoembolization(TACE)for hepatocellular carcinoma(HCC).METHODS:One hundred and eighty-five patients(159men and 26 women)with advanced HCC were enrolled in this study from February 2009 to July 2011.There were 95 patients in the combined metuximab and TACE group,and 90 patients in the TACE only group.The patients were followed for 12 mo.Clinical symptoms,blood cell counts,Karnofsky Performance Score(KPS)evaluation and therapeutic effects according to the Response Evaluation Criteria in Solid Tumors were recorded and evaluated.RESULTS:The 1-mo effective rates(complete response+partial response+stable disease)of the test group and control group were 71.23%and 38.89%,respectively(P<0.001).The 6-,9-and 12-mo survival rates were 86.42%,74.07%and 60.49%for the test group and 60.0%,42.22%and 34.44%for the control group(P<0.001).The incidence of adverse events(gastrointestinal symptoms,fever and pain)and blood cell toxicity were significantly higher for the test group than for the control group(P<0.001).No severe131Imetuximab-related complications were identified.With respect to efficacy,patients in the test group had greater improvement in tumor-related pain(P=0.014)and increase in KPS(P<0.001)than those in the control group.CONCLUSION:Combination of131I-metuximab and TACE prolonged the survival time in patients with HCC compared with TACE alone.The combination treatment was safe and effective. 关键词：HEPATOCELLULAR carcinoma 131 I-metuximab TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION RADIOIMMUNOTHERAPY

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^(131)I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma

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