Cellular and molecular basis of chronic constipation: Taking the functional/idiopathic label out

查看全文 作　　者：Gabrio [1]Bassotti;Vincenzo [2]Villanacci;Dragos [3,4]Cretoiu;Sanda Maria [3,5]Cretoiu;Gabriel [6]Becheanu

机构地区：[1]Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia;[2]Second Pathology Section,Spedali Civili;[3]Division of Cellular and Molecular Medicine, Department of Morphological Sciences, 'Carol Davila' University of Medicine and Pharmacy;[4]Department of Molecular Medicine, 'Victor Babes' National Institute of Pathology;[5]Department of Ultrastructural Pathology, 'Victor Babes' National Institute of Pathology;[6]Department of Gastroenterology and Hepatology, Fundeni Clinical Institute

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第26期,共7页

摘　　要：In recent years, the improvement of technology and the increase in knowledge have shifted several strongly held paradigms. This is particularly true in gastroenterology, and specifically in the field of the so-called 'functional' or 'idiopathic' disease, where conditions thought for decades to be based mainly on alterations of visceral perception or aberrant psychosomatic mechanisms have, in fact, be reconducted to an organic basis (or, at the very least, have shown one or more demonstrable abnormalities). This is particularly true, for instance, for irritable bowel syndrome, the prototype entity of 'functional' gastrointestinal disorders, where low-grade inflammation of both mucosa and myenteric plexus has been repeatedly demonstrated. Thus, researchers have also investigated other functional/idiopathic gastrointestinal disorders, and found that some organic ground is present, such as abnormal neurotransmission and myenteric plexitis in esophageal achalasia and mucosal immune activation and mild eosinophilia in functional dyspepsia. Here we show evidence, based on our own and other authors' work, that chronic constipation has several abnormalities reconductable to alterations in the enteric nervous system, abnormalities mainly characterized by a constant decrease of enteric glial cells and interstitial cells of Cajal (and, sometimes, of enteric neurons). Thus, we feel that (at least some forms of) chronic constipation should no more be considered as a functional/idiopathic gastrointestinal disorder, but instead as a true enteric neuropathic abnormality. 关键词：CONSTIPATION ENTERIC GLIA ENTERIC nervous system ENTERIC neurons INTERSTITIAL cells of Cajap Neurogastroenterology

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Cellular and molecular basis of chronic constipation: Taking the functional/idiopathic label out

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