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Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers

查看全文 作　　者：Masaki [1]Takayama;Shigenaga [1]Matsui;Masanori [1]Kawasaki;Yutaka [1]Asakuma;Toshiharu [1]Sakurai;Hiroshi [1]Kashida;Masatoshi [1]Kudo 高影响力作者 机构地区：[1]Department of Gastroenterology and Hepatology,Kinki University高影响力机构 出　　处：《World Journal of Gastroenterology》索引2013年第19卷第34期,共7页高影响力期刊 摘　　要：AIM:To prospectively compare the healing rates of endoscopic submucosal dissection(ESD)-induced ulcers treated with either a proton-pump inhibitor(PPI)or rebamipide.METHODS:We examined 90 patients with early gastric cancer who had undergone ESD.All patients were administered an intravenous infusion of the PPI lansoprazole(20 mg)every 12 h for 2 d,followed by oral administration of lansoprazole(30 mg/d,5 d).After7-d treatment,the patients were randomly assigned to 2 groups and received either lansoprazole(30 mg/d orally,n=45;PPI group)or rebamipide(300 mg orally,three times a day;n=45;rebamipide group).At 4and 8 wk after ESD,the ulcer outcomes in the 2 groups were compared.RESULTS:No significant differences were noted in patient age,underlying disease,tumor location,Helicobacter pylori infection rate,or ESD-induced ulcersize between the 2 groups.At both 4 and 8 wk,the healing rates of ESD-induced ulcers were similar in the PPI-treated and the rebamipide-treated patients(4 wk:PPI,27.2%;rebamipide,33.3%;P=0.5341;8 wk:PPI,90.9%;rebamipide,93.3%;P=0.6710).At 8 wk,the rates of granulation lesions following ulcer healing were significantly higher in the PPI-treated group(13.6%)than in the rebamipide-treated group(0.0%;P=0.0103).Ulcer-related symptoms were similar in the2 treatment groups at 8 wk.The medication cost of 8-wk treatment with the PPI was 10945 yen vs 4889 yen for rebamipide.No ulcer bleeding or complications due to the drugs were observed in either treatment group.CONCLUSION:The healing rate of ESD-induced ulcers was similar with rebamipide or PPI treatment;however,rebamipide treatment is more cost-effective and prevents granulation lesions following ulcer healing. 关 键 词：Early GASTRIC cancer REBAMIPIDE Endoscopic SUBMUCOSAL DISSECTION GASTRIC ULCER Protonpump inhibitor
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