Implications of Klotho in vascular health and disease

查看全文 作　　者：Ernesto Martín-[1]Núez;Javier Donate-[1]Correa;Mercedes Muros-de-[2]Fuentes;Carmen Mora-[1]Fernández;Juan F Navarro-[3]González 机构地区：[1]Research Unit, University Hospital Nuestra Se?ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain;[2]Clinical Analysis Service and Research Unit, University Hospital Nuestra Se ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain;[3]Nephrology Service and Research Unit, University Hospital Nuestra Se ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain 出　　处：《World Journal of Cardiology》索引2014年第6卷第12期,共8页 基　　金：funded by Ministerio de Economía y Competitividad, Instituto de Salud Carlos Ⅲ (PI13/01726),Sociedad Espa?ola de Nefrología and ACINEF;cofunding by the Fondo Europeo de Desarrollo Regional, Unión Europea ('Una forma de hacer Europa');supported by Programa de Intensificación de la Actividad Investigadora, Instituto de Salud Carlos Ⅲ, Ministerio de Economía y Competitividad (Convenio ISC Ⅲ-Comunidad Autónoma Canarias) 摘　　要：Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity. 关 键 词：maintenance CARDIOVASCULAR HYPERTROPHY HOMEOSTASIS suppression SEVERITY prevalent overview attenuation SCENARIO