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Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

查看全文 作　　者：LI [1,2]QingNing;WU [1]XiaoJing;ZHAO [1]Juan;WU [1]ChangYu;WANG [1]XueMei 高影响力作者 机构地区：[1]State Key Laboratory of Bioelectronics; Southeast University,Nanjing 210096,China;[2]Medical School,Ningbo University,Ningbo 315211,China高影响力机构 出　　处：《Science China Chemistry》索引2011年第54卷第5期,共4页高影响力期刊 基　　金：supported by the National Natural Science Founda-tion of China (90713023 & 20675014);the Natural Science Foundation of Jiangsu Province (BK2008149);the Foundation of Talent Project and disci-pline project of Ningbo University (B00121104700 & XKL126);National High Technology Research and Development Program of China (2007AA022007);Doctoral Fund of Ministry of Education of China (20090092110028);National Basic Research Program of China (2010CB732404);Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, China 摘　　要：In this study,we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore,this new nano-interface and Au-MCNT modified electrode could be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications. 关 键 词：纳米复合材料 修饰电极 实时检测 相互作用 柔红霉素 抗癌药物 癌细胞 癌症
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