Epithelial-mesenchymal transition in breast cancer progression and metastasis

查看全文 作　　者：Yifan [1,2]Wang;Binhua P. [1,2]Zhou

机构地区：[1]Department of Molecular and Cellular Biochemistry,University of Kentucky College of Medicine, Lexington, KY 40506, USA.;[2]Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40506, USA.

出　　处：《Chinese Journal of Cancer》索引2011年第30卷第9期,共9页

基　　金：supported by the grants from NIH (RO1CA125454);the Susan G. Komen Foundation (KG081310);the Mary Kay Ash Foundation (to B.P. Zhou) 摘　　要：Breast cancer is the most common cancer in women,and approximately 90% of breast cancer deaths are caused by local invasion and distant metastasis of tumor cells.Epithelial-mesenchymal transition(EMT) is a vital process for large-scale cell movement during morphogenesis at the time of embryonic development.Tumor cells usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis.Several transcription factors and signals are involved in these events.In this review,we summarize recent advances in breast cancer researches that have provided new insights in the molecular mechanisms underlying EMT regulation during breast cancer progression and metastasis.We especially focus on the molecular pathways that control EMT. 关键词：乳腺癌上皮间质肿瘤细胞分子机制 EMT 胚胎发育细胞运动

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Epithelial-mesenchymal transition in breast cancer progression and metastasis

参考文献(90)

引证文献(36)

耦合文献(101)

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