维普中文期刊产品整合服务

Highly fluorescent,photostable,and biocompatible silicon theranostic nanoprobes against Staphylococcus aureus infections

查看全文 作　　者：Xia [1]Zhai;Bin [1]Song;Binbin [1]Chu;Yuanyuan [1]Su;Houyu [1]Wang;Yao [1]He 高影响力作者 机构地区：[1]Laboratory of Nanoscale Biochemical Analysis,lnstitute of Functional Nano &Soft Materials (FUNSOM),and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC),Soochow University,Suzhou 215123,China高影响力机构 出　　处：《Nano Research》索引2018年第11卷第12期,共11页高影响力期刊 基　　金：the National Natural Science Foundation of China (Nos.61361160412, 31400860,21575096,and 21605109);Natural Science Foundation of Jiangsu Province of China (No.BK20170061) ;the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD),111Project as well as Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC). 摘　　要：Human health is severely threatened by bacterial infections,which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections.To meet this goal,we synthesized a new kind of theranostic probes,made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van).The new probes feature good selectivity for Gram-positive bacterial infections,favorable fluorescence,strong resistance to photobleaching (e.g.,12%loss of fluorescence intensity during 40min continuous laser excitation in the presence of Staphylococcus aureus (S.aureus)),and good biocompatibility (e.g.,cell viability >95%during 24h treatment).Because of these benefits,the probes were effective at prolonged (i.e.,8-day)fluorescence tracking of S.aureus infections in vivo,thus providing a visible and accurate way to evaluate treatment efficacy.Moreover,the resultant SiNPs-Van with a minimum inhibitory concentration (MIC)of ca.0.5μg/mL exhibited high antibacterial efficiency of 92.5%,superior to that (76.5%)of free Van with higher MIC of ca.1μg/mL. 关 键 词：fluorescent SILICON nanoparticles GRAM-POSITIVE bacteria STAPHYLOCOCCUS aureus prolonged extended period
相关文献

参考文献(51)

引证文献(2)

耦合文献(36)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费