The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

查看全文 作　　者：[1]LiaoJH;[2]ChenJS

机构地区：[1]StateKeyLaboratoryofMolecularBiology,InstituteofBiochemistryandCellBiology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences,320YueYangRoad,Shanghai200031,China;[2]StateKeyLaboratoryofMole

出　　处：《Cell Research》索引2001年第11卷第2期,共6页

基　　金：grants fromthe Chinese Academy of Sciences (No. KJ951-BI608), the National Natural Sciences FOundation ofChina (No. 39625007 and 摘　　要：We reported in this manuscript that TGF-β1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-β1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-β1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-β1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-β1-mediated gene expression and apoptosis. 关键词：转化生长因子Β 细胞凋亡 P38 肝细胞信号传导

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The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

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