Structural properties of scaffolds:Crucial parameters towards stem cells differentiation

查看全文 作　　者：Laleh Ghasemi-[1]Mobarakeh;Molamma P [2]Prabhakaran;Lingling [2]Tian;Elham Shamirzaei-[1]Jeshvaghani;Leila [3,4]Dehghani;Seeram [2]Ramakrishna

机构地区：[1]Department of Textile Engineering,Isfahan University of Technology;[2]Department of Mechanical Engineering, Faculty of Engineering,2 Engineering Drive 3,National University of Singapore;[3]Department of Medical Science, Islamic Azad University, Najafabad Branch;[4]Isfahan Neurosciences Research Center,AlZ ahra Hospital, Isfahan University of Medical Sciences

出　　处：《World Journal of Stem Cells》索引2015年第7卷第4期,共17页

摘　　要：Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciencesfor regeneration of damaged tissues. Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. Here, we focus on the recent reports that investigated the various aspects of scaffolds including the materials used for scaffold fabrication, surface modification of scaffolds, topography and mechanical properties of scaffolds towards stem cells differentiation effect. We will present a more detailed overview on the effect of mechanical properties of scaffolds on stem cells fate. 关键词：STEM cells TISSUE engineering DIFFERENTIATION Mechanical properties Surface MODIFICATION TOPOGRAPHY

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Structural properties of scaffolds:Crucial parameters towards stem cells differentiation

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