Manganese-catalyzed bicyclic annulations of imines and α,β-unsaturated esters via C-H activation

查看全文 作　　者：Yuanyuan [1,2]Hu;Congyang [1,2]Wang 机构地区：[1]Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry,Chinese Academy of Sciences;[2]University of Chinese Academy of Sciences 出　　处：《Science China Chemistry》索引2016年第59卷第10期,共5页 基　　金：supported by the National Basic Research Program of China (2012CB821600);the National Natural Science Foundation of China (21322203, 21272238, 21521002) 摘　　要：A manganese-catalyzed bicyclic annulation of imines with α,β-unsaturated esters via C–H activation is described, which provides an expedient access to fused β-lactams in one-step operation with high efficiency and good functional group tolerance. Of note, both ketimines and aldimines are amenable to this transformation. Mechanistic studies have identified a five-membered azamanganacycle as the key reaction intermediate. 关 键 词：C-H键 不饱和酯 酮亚胺 锰催化 双环 活化 反应中间体 耐受性