维普中文期刊产品整合服务

Electroacupuncture induces acute changes in cerebral cortical mi RNA profile, improves cerebral blood flow and alleviates neurological deficits in a rat model of stroke

查看全文 作　　者：Hai-zhen [1,2]Zheng;Wei [3]Jiang;Xiao-feng [1]Zhao;Jing [2]Du;Pan-gong [2]Liu;Li-dan [2]Chang;Wen-bo [2]Li;Han-tong [2]Hu;Xue-min [1,3]Shi 高影响力作者 机构地区：[1]VIP of Acupuncture Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;[2]Tianjin University of Traditional Chinese Medicine, Tianjin, China;[3]Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China高影响力机构 出　　处：《Neural Regeneration Research》索引2016年第11卷第12期,共11页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China,No.81173416 摘　　要：Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters mi RNA expression in the cortex. In this study, we examined changes in the cerebral cortical mi RNA profile, cerebral blood flow and neurological function induced by electroacupuncture in a rat model of stroke. Electroacupuncture was performed at Renzhong(GV26) and Neiguan(PC6), with a frequency of 2 Hz, continuous wave, current intensity of 3.0 m A, and stimulation time of 1 minute. Electroacupuncture increased cerebral blood flow and alleviated neurological impairment in the rats. mi RNA microarray profiling revealed that the vascular endothelial growth factor signaling pathway, which links cell proliferation with stroke, was most significantly affected by electroacupuncture. Electroacupuncture induced changes in expression of rno-mi R-206-3p, rno-mi R-3473, rno-mi R-6216 and rno-mi R-494-3p, and these changes were confirmed by quantitative real-time polymerase chain reaction. Our findings suggest that changes in cell proliferation-associated mi RNA expression induced by electroacupuncture might be associated with the improved cerebral blood supply and functional recovery following stroke. 关 键 词：神经功能 脑卒中 RNA 血流量 电针 诱导 大鼠 皮质
相关文献

参考文献(52)

引证文献(24)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费