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The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes

查看全文 作　　者：Juan [1,2]Chen;Zhaokui [1,2]Cai;Meizhu [3,4]Bai;Xiaohua [1,2]Yu;Chao [5]Zhang;Changchang [1,2]Cao;Xihao [1,2]Hu;Lei [1,6]Wang;Ruibao [1,2]Su;Di [1,2]Wang;Yingpeng [7]Yao;Rong [1,2]Ye;Baidong [5]Hou;Yang [1]Yu;Shuyang [7]Yu;Jinsong [3,4]Li;Yuanchao [1,2]xue 高影响力作者 机构地区：[1]Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China;[2]University of Chinese Academy of Sciences, 100049 Beijing, China;[3]State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 Yueyang Road, 200031 Shanghai, China;[4]School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, 201210 Shanghai, China;[5]SKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China;[6]College of Life Sciences, Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, 464000 Xinyang, China;[7]State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People's Republic of China高影响力机构 出　　处：《Cell Research》索引2018年第28卷第10期,共15页高影响力期刊 基　　金：We thank Dr. Tasuku Honjo and Dr. Weifeng Mao for the CH12F3 cell line; Dr. Fei- Long Meng for AID / mice, as well as his expertise, advice, and communication during the project; and Dr. Hong-Jie Zhang (faculty of IBP) for the detection and operation of P-32. This work was supported by the Ministry of Science and Technology of China (2016YFC0900400 and 2017YFA0504400), the Strategic Priority of Research Program of the Chinese Academy of Sciences (XDB19000000), the National Natural Science Foundation of China (91440101, 31522015), and the Key programs of the Chinese Academy of Sciences (KJZD-EW-L12) grants to Y.C.X.; by Natural Science Foundation of China (31601058, 31601107) to J.C. and X.H.Y.; by the Ministry of Science and Technology of China (2014CB964803), the National Natural Science Foundation of China (31530048) and the Chinese Academy of Sciences (XDB19010203) grants to J.L 关 键 词：RNA 蛋白质 染色体 哺乳动物 抗体 地点 装载 定义
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