Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells

查看全文 作　　者：Ting-Ting [1]Li;Hao [1]Liu;Jiang [1]Yu;Guang-Yao [2]Shi;Li-Ying [1]Zhao;Guo-Xin [1]Li

机构地区：[1]Department of General Surgery,Nanfang Hospital,Southern Medical University;[2]Division of Cardiology,Third Affiliated Hospital,Sun Yat-sen University

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第21期,共11页

基　　金：Supported by the Guangdong Provincial Natural Science Foundation,No.2016A030313843 摘　　要：Gastric cancer(GC), with its high incidence and mortality rates, is a highly fatal cancer that is common in East Asia particularly in China. Its recurrence and metastasis are the main causes of its poor prognosis. Circulating tumor cells(CTCs) or other blood biomarkers that are released into the circulating blood stream by tumors are thought to play a crucial role in the recurrence and metastasis of gastric cancer. Therefore, the detection of CTCs and other blood biomarkers has an important clinical significance; in fact, they can help predict the prognosis, assess the staging, monitor the therapeutic effects and determine the drug susceptibility. Recent research has identified many blood biomarkers in GC, such as various serum proteins, autoantibodies against tumor associated antigens, and cell-free DNAs. The analysis of CTCs and circulating cell-free tumor DNA(ctDNA) in the peripheral blood of patients with gastric cancer is called as liquid biopsy. These blood biomarkers provide the disease status for individuals and have clinical meaning. In this review, we focus on the recent scientific advances regarding CTCs and other blood biomarkers, and discuss their origins and clinical meaning. 关键词：Gastric cancer BIOMARKER CIRCULATING tumor cells AUTOANTIBODIES CELL-FREE DNA

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Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells

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