Multiple cytokine profiling in serum for early detection of gastric cancer

查看全文 作　　者：Jian [1]Li;Liang [2]Xu;Zeng-Ci [1]Run;Wen [3]Feng;Wen [4]Liu;Peng-Jun [5]Zhang;Zhi [1]Li

机构地区：[1]Department of general surgery,Affiliated Tumor Hospital of Zhengzhou University;[2]Department of Oncology,General Hospital of Liaohe Oil Field;[3]Department of Pathology,Affiliated Tumor Hospital of Zhengzhou University;[4]Department of Central Laboratory,Affiliated Tumor Hospital of Zhengzhou University;[5]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),Interventional Therapy Department,Peking University Cancer Hospital & Institute

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第21期,共10页

基　　金：Supported by Henan Province science and Technology Research Projects,No.162102310041;National Key R&D Program of China,No.2016YFC0106604;National Natural Science Foundation of China,No.81502591 摘　　要：AIM To investigate the value of multiparameter joint analysis in the early diagnosis of gastric cancer(GC) in clinical practice.METHODS Concentrations of CEA, CA724 and three kinds of cytokines(TNF-α, IL-6 and IL-8) in 176 GC patients, 117 atypical hyperplasia patients, and 204 healthy control individuals were used for building the diagnostic model, then 58 GC patients, 41 atypical hyperplasia patients, and 66 healthy control individuals were enrolled independently. The joints of the indicators were analyzed by binary logistic regression analysis method.RESULTS For discriminating the healthy control group and the GC group, IL-6 had the best diagnostic value, and the area under curve(AUC) of joint analysis was 0.95(0.93-0.97). For the early stage and advanced stage GC, the AUC were 0.95(0.92-0.98) and 0.95(0.92-0.97). For discriminating the atypical hyperplasia group and GC group, CA724 had the best diagnostic value, and the AUC of joint analysis was 0.97(0.95-0.99). For the early stage and advanced stage GC groups, the AUC were 0.98(0.96-0.99) and 0.96(0.94-0.98). After evaluation, for discriminating the GC, early stage GC and advanced cancer group from the healthy control group, the diagnostic sensitivity was 89.66%, 84.21% and 92.31%, respectively, and the specificity was 92.42%, 90.91% and 90.91%. For discriminating the GC, early stage GC and advanced cancer groups from the atypical hyperplasia group, the diagnostic sensitivity was 87.93%, 78.95% and 92.31%, respectively, and the specificity was 87.80%, 85.37% and 90.24%.CONCLUSION We have built a diagnostic model including CEA, CA724, IL-6, IL-8, and TNF-α. It may provide potential assistance as a screening method for the early detection of GC. 关键词：GASTRIC cancer ATYPICAL HYPERPLASIA SERUM CYTOKINE Early detection

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Multiple cytokine profiling in serum for early detection of gastric cancer

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